Information and Communication Technologies (ICTs) are gradually becoming important artifacts for people with disabilities (PWDs). This paper investigates the use of mobile phones in the daily activities of PWDs in sub‐Saharan Africa. The study argues that mobile phone use empowers PWDs, but little is known about what contextual factors and under what underlying mechanisms such empowerment occurs. By adopting Thapa and Omland's (2018) critical realism methodology, we aim to understand the underlying mechanisms, structures and conditions that shape empowerment through mobile phone use by PWDs in Nigeria. The Capability Approach (CA) was engaged as the theoretical framework. Semi‐structured interviews and focus group discussions with twenty‐four PWDs were used as the primary source of data. Our findings reveal that contextual factors such as personal, social and environmental factors enable/hinder empowerment for PWDs. Similarly, mechanisms such as accessibility and acceptability, technology knowledge, social media and mobile phone features are found to be the main underlying mechanisms triggering the events we observed. However, we argue that these mechanisms are enacted from other enabling structures such as the ubiquity of mobile phones, caregivers and contextual conditions like the personal innovativeness in mobile phone use and the low price of mobile phones. Our findings contribute to the critical realism methodology, policy and theory.