Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?

Ye, Ling-li; Zhang, Guanghui; Huang, Jiefu; Li, Yong; Zheng, Guoqiao; Zhang, De-ting; Zhou, Lifang; Tao, Xi-dan; Zhang, Jing; Ye, Yunjie; Sun, Pin; Frank, Arthur L.; Zhang, Xia

doi:10.1179/2049396714y.0000000091

Cited by 19 publications

(29 citation statements)

References 40 publications

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“…The values observed herein are consistent with those reported in the literature and corroborate that the hematological alterations observed in this study may be associated with benzene exposure, even at low levels, as described by other authors 9,25,44,45,46 .…”

Section: Urinary S-pma Analysessupporting

confidence: 93%

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Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G>C and NQO1 609C>T) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil

et al. 2019

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Benzene is one of the most important substances for assessment, due to its significant use, the environmental contamination resulting from its emission and the effects on human health. It is classified by the International Agency for Research on Cancer (IARC) as a known carcinogen to humans (group 1) and associated with the development of leukemia. In general, the population is exposed to this substance by inhaling contaminated air, which varies according to the location and intensity of its potential sources. The petrochemical industry is one of the most important sources of this compound. The municipality of Duque de Caxias, specifically the Campos Elíseos district, in Rio de Janeiro State, Brazil, houses the Industrial Complex of Campos Elíseos (PICE), a grouping of over 25 industries, which includes the second largest oil refinery in Brazil. Environmental contamination from the PICE has been recognized, but there is a lack of studies concerning its impact on the health of the surrounding population. S-phenylmercapturic acid (S-PMA) concentrations ranging from 0.80 to 8.01μg.g-1 creatinine were observed in the local population, apparently related to hematological changes also observed in exposed population. The quantifiable presence of urinary S-PMA from the benzene metabolism is associated with the fact that 60% of the participants present specific hematological changes, which may be due to the environmental benzene exposure. The allele and genotype frequencies of the CYP2E1 and NQO1 enzymes observed in the study population were similar to those reported in other studies. The presence of the variant allele in the NQO1 genotype may be a risk factor for the observed hematological changes.

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Section: Urinary S-pma Analysessupporting

confidence: 93%

“…Ye et al 45 also observed that the presence of the variant allele confers a greater susceptibility to hematological changes related to benzene. Thus, participants who presented the CC genotype displayed a reduction in white cell counts.…”

Section: Molecular Analyses • Genotype and Allele Frequencies Of Cyp2mentioning

confidence: 96%

Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G>C and NQO1 609C>T) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil

et al. 2019

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“…Similarly, Qu et al reported a decrease in RBC, WBC and neutrophils at exposure to 0.25 ppm of benzene or less in Chinese workers (Qu et al 2002 ). Likewise, Ye et al reported decreased WBC in Chinese workers occupationally exposed to low levels of benzene (equal to 1 ppm) (Ye et al 2015 ). Conversely, in some studies, no significant decreases have been observed in CBC parameters as a result of exposure to low levels of benzene.…”

Section: Discussionmentioning

confidence: 98%

“…Similarly, Hsieh et al found that individuals with both positive GSTT1 and GSTM1 genotypes showed the highest prevalence of low WBC when the benzene exposure was high (Hsieh et al 1999 ). Conversely, Ye et al reported lower WBC counts in workers with null GSTT1 and null GSTM1 genotypes (Ye et al 2015 ). However, apart from GSTs, numerous other enzymes are also involved in the metabolism of benzene.…”

Section: Discussionmentioning

confidence: 99%

“…Acute exposure to high concentrations of benzene can affect the central nervous system and cause dizziness, headaches, and nausea (Edokpolo et al 2015), while, chronic exposure to benzene causes leukemia, anemia, leukopenia, thrombocytopenia, acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), myelodysplastic syndrome, and non-hodgkin lymphoma (Kim et al 2007; Wan et al 2002; Schnattera et al 2010; Swaen et al 2010; Ye et al 2015). Similarly, some studies have reported genotoxicity, increased levels of persistent chromosome aberrations and reproductive effects as a result of exposure to benzene (Edokpolo et al 2015).…”

Section: Introductionmentioning

confidence: 99%

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Association between polymorphism of GSTP1, GSTT1, GSTM1 and CYP2E1 genes and susceptibility to benzene-induced hematotoxicity

et al. 2017

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Occupational exposure to benzene has been associated with leukemia, anemia, leukopenia, and thrombocytopenia. Genetic susceptibility to benzene toxicity in humans may be related to variations in benzene metabolizing genes. The main objective of this study was to ascertain whether polymorphism of GSTP1, GSTM1, GSTT1 and CYP2E1 genes might influence susceptibility to the adverse effects of benzene among employees of a petrochemical plant. In this cross-sectional study, 124 employees of a petrochemical plant who had been occupationally exposed to benzene and had one or more abnormal hematological parameter (cases) and 184 subjects with a similar exposure scenario, free from any abnormal hematological parameters (referent) were studied. Atmospheric concentrations of benzene were measured and GSTM1 and GSTT1 genotypes were evaluated using the multiplex polymerase chain reaction (PCR) technique. Additionally, GSTP1 and CYP2E1 genotypes were determined by PCR- restriction fragment length polymorphism (PCR–RFLP). The frequency of null GSTT1 genotype in cases was significantly higher than that of referent group (32.3 vs. 18.5%, OR 2.1, 95% CI 1.23–3.56, p = 0.004). The mean value of platelets in subjects with null GSTT1 genotype was significantly lower than that of individuals with positive GSTT1 genotype (p = 0.015). Conversely, the mean value of leukocytes was significantly higher in subjects with null GSTM1 genotype as compared to those with positive GSTM1 genotype (p = 0.026). Logistic regression analysis showed that, subjects with null GSTT1 genotype had a significantly higher risk for hematological disorders, as compared to those with positive GSTT1 genotype (OR 2.1, 95% CI 1.23–3.56). Moreover, subjects with both null GSTT1 and GSTM1 genotypes had a significantly higher risk for hematological disorders as compared to subjects with positive GSTT1 and GSTM1 genotypes (OR 2.35, 95% CI 1.14–4.8). The results of this study showed that, individuals carrying null GSTT1 or both null STT1 and GSTM1 genotypes had a higher risk and were more susceptible to benzene-induced hematological disorders.

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Biological Monitoring of Exposure to Industrial Chemicals

Hopf

Fustinoni

2021

Patty's Industrial Hygiene

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Human biological monitoring is a powerful tool for scientists, policy makers, and occupational health‐care professionals, such as physicians and occupational hygienists, to assess and manage health risks associated with chemical exposures among the general population as well as at the workplace. This chapter will focus on using biological monitoring in occupational exposure assessments. It includes biological monitoring sampling strategies and practical approaches. Relevant biomarkers used in biomonitoring are derived based on fundamental understanding of absorption, distribution, metabolism, and excretion (ADME) of chemicals. Therefore, ADME will be discussed along with toxicokinetics and toxicodynamics. Individual susceptibility is a topic associated with biological monitoring as opposed to air monitoring. Monitoring variability associated with air and biological monitoring is compared. The biomonitoring strategy choice is dependent on the purpose, selected biomarker, matrix (urine, blood, saliva, hair, exhaled breath, exhaled breath condensate), sampling time, which is determined based on the selected biomarkers apparent elimination half‐life, and variability but also on the purpose of the biomonitoring program. Biological limit values are established on available scientific data. Their historic development and concepts are country specific. Biomonitoring of metals and inorganic compounds as well as organic compounds are extensively covered. Emerging biomarker fields as well as new chemical analytical methods are briefly discussed. Future trends in human biological monitoring are discussed as it is a current topic in public health policies, in occupational and environmental health and in science in general.

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Are polymorphisms in metabolism protective or a risk for reduced white blood cell counts in a Chinese population with low occupational benzene exposures?

Cited by 19 publications

References 40 publications

Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G>C and NQO1 609C>T) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil

Environmental exposure to benzene: evaluation of urinary S-PMA and polymorphism (CYP2E1-1293G>C and NQO1 609C>T) in Campos Elíseos residents, Duque de Caxias, Rio de Janeiro State, Brazil

Association between polymorphism of GSTP1, GSTT1, GSTM1 and CYP2E1 genes and susceptibility to benzene-induced hematotoxicity

Biological Monitoring of Exposure to Industrial Chemicals

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