Are polymyalgia rheumatica and giant cell arteritis the same disease?

Cantini, Fabrizio; Niccoli, Laura; Storri, Lara; Nannini, Carlotta; Olivieri, Ignazio; Padula, Angela; Boiardi, Luigi; Salvarani, Carlo

doi:10.1016/j.semarthrit.2003.09.008

Cited by 97 publications

(50 citation statements)

References 59 publications

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“…Our patient population displayed the typical features of GCA as reflected by age, male:female ratio, and frequency of polymyalgia rheumatica symptoms (7).…”

Section: Discussionmentioning

confidence: 67%

Repetitive ¹⁸F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients

Blockmans

Ceuninck

Vanderschueren

et al. 2006

Arthritis & Rheumatism

563

120

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Objective. To study fluorodeoxyglucose (FDG) uptake in the different vascular beds and in the large joints of patients with giant cell arteritis (GCA) at diagnosis, during steroid treatment, and at relapse. Methods. All consecutive patients admitted to our department with a diagnosis of GCA underwent FDG-positron emission tomography (PET) scan before treatment with methylprednisolone was started. PET scans were repeated at 3 and 6 months, if the initial PET scans showed vascular FDG uptake. PET scans were scored at 7 different vascular areas and a total vascular score (TVS) was calculated, ranging from 0 to 21. Results. A total of 35 patients entered the study. At diagnosis, vascular FDG uptake was noted in 29 patients (83%), especially in the subclavian arteries (74%), but also in the aorta (>50%) and up to the femoral arteries (37%). TVS decreased from a mean ؎ SD score of 7.9 ؎ 5.5 at baseline to 2.4 ؎ 3.5 on repeat PET scan at 3 months (P < 0.0005), but did not further decrease at 6 months. The patients who relapsed had similar earlier decreases of TVS compared with those who did not relapse. FDG uptake in the shoulders at diagnosis correlated significantly with the presence of polymyalgia rheumatica (P ‫؍‬ 0.005). Conclusion. FDG uptake in the large vessels is a sensitive marker for GCA, which can involve the larger thoracic, abdominal, and peripheral arteries. Polymyalgia rheumatica symptoms in patients with GCA correlate with (peri)synovitis of the shoulders. Relapses of GCA cannot be predicted by results of former PET scintigraphies.

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“…Our patient population displayed the typical features of GCA as reflected by age, male:female ratio, and frequency of polymyalgia rheumatica symptoms (7).…”

Section: Discussionmentioning

confidence: 67%

Repetitive ¹⁸F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients

Blockmans

Ceuninck

Vanderschueren

et al. 2006

Arthritis & Rheumatism

563

120

View full text Add to dashboard Cite

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“…Although PMR and GCA are closely related and overlapping, it remains equivocal whether these two conditions are the same disease entity with different presentations [6,34,35]. Alternatively, several differences in the genetic background and course of the disease have been noted between PMR and GCA [35,36]. HLA-DRB1 is overrepresented in patients with GCA when compared with controls [37].…”

Section: Discussionmentioning

confidence: 99%

Polymyalgia Rheumatica and the Risk of Stroke: A Three-Year Follow-Up Study

2011

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Background: Polymyalgia rheumatica (PMR) is a relatively common rheumatic disease, particularly in the elderly. Vasculitis is associated with PMR and theoretically makes such patients susceptible to vascular events such as stroke. This study aims to explore the frequency and risk of stroke among patients with PMR through a population-based case-controlled study. Methods: The study included 781 patients with PMR from the Taiwan Longitudinal Health Insurance Database between 2001 and 2005. We randomly extracted 3,905 other patients, matched with the study group in terms of sex and age, as a control population. Each subject was individually tracked for a three-year period to identify those who had strokes. Stratified Cox proportional hazard regression was employed to evaluate the risk of stroke, after adjusting for socio-demographic characteristics and comorbidities. Results: We found that 386 out of 4,686 sampled patients (8.24%) had stroke during the three-year follow-up period, including 113 patients with PMR (14.47% of the PMR group) and 273 controls (6.98% of the control group). The stratified Cox proportional hazard regression showed that the adjusted hazard ratio of stroke for patients with PMR was 2.09 times that of controls (95% CI = 1.63–2.66, p <0.001), after adjusting for socio-demographic characteristics and comorbidities. Conclusions: PMR was associated with a significantly higher risk of stroke in the three-year follow-up period. Physicians should be aware of this potential association in clinical settings.

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“…A histopatologia revela panarterite com células gigantes multinucleadas. [74][75][76][77][78][79][80][81][82][83][84][85] Os critérios para o diagnóstico da arterite de células gigantes são os preconizados pelo Colégio Americano de Reumatologia. …”

Section: Arterite De Células Gigantes (Arterite Temporal)unclassified

Vasculites dos médios e grandes vasos

Brandt

Arnone

Valente

et al. 2009

An. Bras. Dermatol.

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Resumo:As vasculites são constituídas por um grande grupo de síndromes caracterizadas por inflamação e necrose da parede dos vasos sangüíneos, resultando em estreitamento ou oclusão do lúmen. A distribuição dos vasos envolvidos varia consideravelmente e serve de base para a classificação das síndromes vasculíticas: grandes vasos (arterite de Takayasu, arterite temporal); pequenos e médios vasos (poliarterite nodosa, síndrome de Churg-Strauss, granulomatose de Wegener, vasculites nas doenças reumáticas); e pequenos vasos (vasculite de hipersensibilidade, púrpura de Henoch-Schonlein, poliangeíte microscópica, crioglobulinemia). Este artigo revisa as vasculites dos médios e grandes vasos e opções terapêuticas atuais; além de oferecer orientação sobre abordagem diagnóstica e tratamento dos pacientes com suspeita de vasculite cutânea. Palavras-chave: Anticorpos anticitoplasma de neutrófilos; Arterite de células gigantes; Arterite de Takayasu; Doenças reumáticas; Granulomatose de Wegener; Poliarterite nodosa; Púrpura; Síndrome de Churg-Strauss; Vasculite; Vasculite alérgica cutânea Abstract: Vasculitis comprises a broad group of syndromes characterized by inflammation and necrosis on the walls of blood vessels, resulting in narrowing or occlusion of the lumen. The distribution of involved blood vessel varies considerably and serves as the basis for one classification of vasculitic syndromes: large vessels (Takayasu arteritis, giant cell arteritis); medium and small muscular arteries (polyarteritis nodosa, Churg-Strauss syndrome, Wegener's granulomatosis, vasculitis in rheumatic diseases); and small vessels ("hypersensitivity" vasculitis, Henoch-Schonlein purpura, microscopic polyangiitis, cryoglobulinemia). This article reviews medium and large vessel vasculitis and current treatment options; it also presents a comprehensive approach to diagnosing and treating patients with suspected cutaneous vasculitis.

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Are polymyalgia rheumatica and giant cell arteritis the same disease?

Cited by 97 publications

References 59 publications

Repetitive ¹⁸F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients

Repetitive ¹⁸F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients

Polymyalgia Rheumatica and the Risk of Stroke: A Three-Year Follow-Up Study

Vasculites dos médios e grandes vasos

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Are polymyalgia rheumatica and giant cell arteritis the same disease?

Cited by 97 publications

References 59 publications

Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients

Repetitive 18F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients

Polymyalgia Rheumatica and the Risk of Stroke: A Three-Year Follow-Up Study

Vasculites dos médios e grandes vasos

Contact Info

Product

Resources

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Repetitive ¹⁸F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients

Repetitive ¹⁸F‐fluorodeoxyglucose positron emission tomography in giant cell arteritis: A prospective study of 35 patients