Are pretransplant psychological variables related to survival after bone marrow transplantation? a prospective study of 123 consecutive patients

list. BMT-related variables were obtained from medical files. Of the generic QOL measures, most results fell within the normal range of functioning, although some illness-related impairment was reported on subscales for general and work-related functioning. Compared to a reference sample of patients who had received BMT as adults, patients involved in this study scored significantly higher on the 'emotional well-being' subscale of the FACT-BMT, indicating significantly better emotional functioning. The age at BMT and total body irradiation (TBI) were not related to patients' QOL. We can conclude that at long term, having received BMT during childhood does not negatively affect the QOL of patients.

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“…Studies already conducted on adult BMT recipients could be used as a model for developing studies on children receiving BMT. 21,61 …”

Section: Discussionmentioning

confidence: 99%

Quality of life in adults following bone marrow transplantation during childhood

Helder

Bakker

Heer

et al. 2003

Bone Marrow Transplant

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“…The other four were prospective studies, [5][6][7][8] although only one of these four studies 6 included negative emotion in the multivariate analysis. In addition, three of these four prospective studies [7][8][9] contained small sample sizes (mean n ¼ 45), which might have compromised the statistical power to detect the effects; the remaining two larger studies (n4110) 5,6 employed psychometrically validated measures of depressive symptomatology, thus lending credence to their findings. Nevertheless, only one of these studies 6 included depressive symptomatology in their multivariate analysis, and failed to show negative influence of depressed mood on survival.…”

Section: Negative Emotions and Survivalmentioning

confidence: 99%

Do negative or positive emotions differentially impact mortality after adult stem cell transplant?

Hoodin

Uberti

Lynch

et al. 2006

Bone Marrow Transplant

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“…1 That psychosocial factors have been reported either associated with or predictive of treatment-related vulnerability [2][3][4][5] and survival, [6][7][8][9][10][11][12][13][14][15] suggests that psychosocial issues may also be important as eligibility criteria for BMT. That notwithstanding, there are studies in the BMT literature [16][17][18] which are either inconclusive or do not support the prognostic value of psychosocial variables. Thus, while most transplant clinicians believe that psychosocial issues may be important determinants of patient eligibility, it is unclear what issues are important and if and how they affect the decision to proceed with allogeneic BMT.…”

Section: Introductionmentioning

confidence: 99%

Allogeneic BMT and patient eligibility based on psychosocial criteria: a survey of BMT professionals

Foster

McLellan

Rybicki

et al. 2005

Bone Marrow Transplant

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BMT professionals were compared regarding their willingness to proceed with allogeneic BMT given select psychosocial issues. A questionnaire was sent to 660 physician members of ASBMT, 92 social work members of BMT Special Interest Group, Association of Oncology Social Work, and 626 nurse members of BMT Special Interest Group, Oncology Nursing Society; 597 responded with a response rate of 43.5%. Items included background information, followed by 17 case vignettes; each represented a different psychosocial issue to which respondents indicated whether or not they would recommend proceeding with allogeneic BMT. In every vignette, at least 10% of respondents indicated they would not proceed. In six vignettes, at least 64% indicated do not proceed: suicidal ideation (86.8%), uses addictive illicit drugs (81.7%), history of noncompliance (80.5%), no lay caregiver (69.3%), alcoholic (64.8%), and mild dementia/Alzheimer's (64.4%). In 10 vignettes, at least 73% indicated proceed. On four vignettes, professional subgroups differed in their recommendation on whether or not to proceed with allogeneic BMT. Qualitative data suggest that this decision is contingent on the perceived acuity, severity, and currency of the psychosocial issue, patient ability to comply with treatment given the issue, and its manageability as a risk factor for treatment related vulnerability and outcomes.

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Are pretransplant psychological variables related to survival after bone marrow transplantation? a prospective study of 123 consecutive patients

Cited by 56 publications

References 24 publications

Quality of life in adults following bone marrow transplantation during childhood

Quality of life in adults following bone marrow transplantation during childhood

Do negative or positive emotions differentially impact mortality after adult stem cell transplant?

Allogeneic BMT and patient eligibility based on psychosocial criteria: a survey of BMT professionals

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