Based on the concept of ontological states and their dynamical evolution by permutations, as assumed in the Cellular Automaton Interpretation (CAI) of quantum mechanics, we address the issue whether quantum-classical hybrids can be described consistently in this framework. We consider chains of 'classical' two-state Ising spins and their discrete deterministic dynamics as an ontological model with an unitary evolution operator generated by pair exchange interactions. A simple error mechanism is identified, which turns them into quantum mechanical objects, chains of qubits. Consequently, an interaction between a quantum mechanical and a 'classical' chain can be introduced and its consequences for this quantum-classical hybrid be studied. We find that such hybrid character of composites, generally, does not persist under interactions and, therefore, cannot be upheld consistently, or even as a fundamental notion à la Kopenhagen interpretation, within CAI.