Are serum uric acid levels predictors of cardiovascular risk? An update

Georgoulis, Michael; Mikhailidis, Dimitri P.; Panagiotakos, Demosthenes B.

doi:10.1097/hco.0000000000001029

Cited by 6 publications

(1 citation statement)

References 63 publications

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“…Though the differences in SBP between the UA groups were not clinically significant. Previous study authors [37,38] reported significant associations between SBP and UA. Hyperuricemia may cause endothelial dysfunction and oxidative stress which can cause reduced blood vessel elasticity and increase stenosis, which can also be associated with elevated levels of SBP.…”

Section: Discussionmentioning

confidence: 81%

Uric Acid as a Novel Component of Metabolic Syndrome

Rodney G,

Kathleen A,

Luke T

2023

Int J Clin Cardiol

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Objective: Uric continues to be explored as a novel risk factor for Metabolic Syndrome. The purpose of our study was to identify risk factors that are associated with hyperuricemia and to better understand if uric acid might serve as a useful component of metabolic syndrome. Methods:A cross-sectional data analysis was conducted using the 2013-2018 NHANES datasets. Sample weights were assigned by NHANES researchers to each participant allowing researchers to generalize results to all non-institutionalized US civilians. The analysis included 6,432 individuals, which were representative of 94,729,059 US citizens. Results:We demonstrated that the risk factors that had a statistically significant relationship with UA value were fasting glucose, triglycerides, systolic BP, and waist circumference. Fasting blood glucose had an inverse relationship with UA level, indicating that for every 1-point increase in fasting blood glucose, uric acid level decreased slightly. The most adjusted model reports HDL also demonstrated an inverse relationship with UA but this relationship was attenuated after controlling for potential confounders. Triglyceride level, systolic BP, and WC had direct relationships with UA level, indicating that as each risk factor increased, UA level also increased. Waist circumference had the greatest clinical significance for UA level. Conclusions:The findings from our study suggest that metabolic syndrome risk factors do have a relationship with UA level, both in the total population and in those with metabolic syndrome. We found general trends that indicated that fasting blood glucose and HDL had negative relationships with UA level, whereas triglycerides, systolic BP, and waist circumference have positive relationships with UA. Diastolic BP did not demonstrate a relationship with UA level, and the relationship between HDL and UA was attenuated after adjustment for confounding variables. The findings suggest a need to further explore UA as a novel risk factor for metabolic syndrome.

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Section: Discussionmentioning

confidence: 81%

Uric Acid as a Novel Component of Metabolic Syndrome

Rodney G,

Kathleen A,

Luke T

2023

Int J Clin Cardiol

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Mediterranean diet trajectories and 20-year incidence of cardiovascular disease: The ATTICA cohort study (2002–2022)

Georgoulis,

Damigou,

Chrysohoou

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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Hyperuricemia and its related diseases: mechanisms and advances in therapy

Du,

Zong,

et al. 2024

Sig Transduct Target Ther

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Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic syndrome, and diabetes, etc. Significantly impairing the quality of life for those affected, the prevalence of hyperuricemia is an upward trend globally, especially in most developed countries. UA possesses a multifaceted role, such as antioxidant, pro-oxidative, pro-inflammatory, nitric oxide modulating, anti-aging, and immune effects, which are significant in both physiological and pathological contexts. The equilibrium of circulating urate levels hinges on the interplay between production and excretion, a delicate balance orchestrated by urate transporter functions across various epithelial tissues and cell types. While existing research has identified hyperuricemia involvement in numerous biological processes and signaling pathways, the precise mechanisms connecting elevated UA levels to disease etiology remain to be fully elucidated. In addition, the influence of genetic susceptibilities and environmental determinants on hyperuricemia calls for a detailed and nuanced examination. This review compiles data from global epidemiological studies and clinical practices, exploring the physiological processes and the genetic foundations of urate transporters in depth. Furthermore, we uncover the complex mechanisms by which the UA induced inflammation influences metabolic processes in individuals with hyperuricemia and the association with its relative disease, offering a foundation for innovative therapeutic approaches and advanced pharmacological strategies.

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Are serum uric acid levels predictors of cardiovascular risk? An update

Cited by 6 publications

References 63 publications

Uric Acid as a Novel Component of Metabolic Syndrome

Uric Acid as a Novel Component of Metabolic Syndrome

Mediterranean diet trajectories and 20-year incidence of cardiovascular disease: The ATTICA cohort study (2002–2022)

Hyperuricemia and its related diseases: mechanisms and advances in therapy

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