Are Smoking Cessation Treatments Associated with Suicidality Risk? An Overview

Penberthy, J. Kim; Penberthy, J. Morgan; Harris, Marcus R.; Nanda, Sonali; Ahn, Jennifer; Martinez, Caridad Ponce; Osika, Apule O.; Slepian, Zoe A.; Forsyth, Justin; Starr, John; Farrell, Jennifer; Hook, Joshua N.

doi:10.4137/sart.s33389

Cited by 5 publications

(5 citation statements)

References 87 publications

(166 reference statements)

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“…In contrast, suicidality risks did not appear to show a significant increase associated with use of any specific smoking cessation pharmacotherapy. 39 Cigarette smoking itself is considered a predictor of suicidal acts. 35 , 40 Given these conflicting data, we considered that the evaluation of the suicidality risk for SCT is difficult.…”

Section: Discussionmentioning

confidence: 99%

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Adverse events of smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes in the Food and Drug Administration Adverse Event Reporting System, 2004−2016

et al. 2018

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Objectives:Several smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes are widely used. We evaluated the adverse events related to smoking cessation treatments and electronic cigarettes in the US Food and Drug Administration Adverse Event Reporting System database.Methods:We analyzed reports of adverse events associated with smoking cessation treatment and electronic cigarettes terms dated between January 2004 and December 2016. We used the reporting odds ratio with 95% confidence intervals to detect a signal for each adverse event.Results:In total, 8,867,135 reports in the Food and Drug Administration Adverse Event Reporting System database were analyzed. The numbers of adverse events for nicotine replacement therapy (transdermal, buccal, oral, and respiratory administration) were 1673, 1016, 425, and 56, respectively. Nicotine replacement therapy (transdermal, buccal, and oral) demonstrated adverse events of nausea, nicotine dependence, and dizziness. For nicotine (transdermal) exposure, the top 5 adverse events reported were nausea (149 cases, reporting odds ratio: 2.28 (95% confidence interval: 1.92–2.69)), dizziness (132 cases, reporting odds ratio: 3.04 (95% confidence interval: 2.54–3.63)), application site erythema (108 cases, reporting odds ratio: 32.52 (95% confidence interval: 26.74–39.55)), headache (98 cases, reporting odds ratio: 1.84 (95% confidence interval: 1.50–2.25)), and dyspnea (94 cases, reporting odds ratio: 1.93 (95% confidence interval: 1.57–2.38)). Many cases of improper use of nicotine replacement therapies were reported. Nausea, depression, abnormal dreams, insomnia, and other adverse events were reported for varenicline. Insomnia, rash, anxiety, and dizziness were reported for bupropion. We observed electronic cigarettes–related adverse events such as dizziness, dyspnea, nausea, heart rate increased, and tremor.Conclusion:Our findings suggest that an association exists between nicotine-related adverse events and nicotine replacement therapy. Healthcare professionals should closely monitor smokers trying to quit nicotine use for the misuse of nicotine replacement therapy. These findings may be informative to healthcare professionals in order to improve the management of smoking cessation treatment.

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Section: Discussionmentioning

confidence: 99%

“…29 3). The numbers of cases were as follows: drug ineffective (143), wrong technique in product usage process (117), intentional drug misuse ( 52), incorrect dose administered (45), incorrect drug administration duration (40), expired product administered (39), drug administration error (35), and overdose (34). 4).…”

Section: Nrtmentioning

confidence: 99%

Adverse events of smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes in the Food and Drug Administration Adverse Event Reporting System, 2004−2016

et al. 2018

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“…Suicide contributes to 1.4% of the global burden of disease, and the majority of cases belong to the age group of 15-35 years [4]. Several studies have demonstrated that nicotine or tobacco dependence is associated with suicide [5][6][7][8][9][10]. In addition, some epidemiological studies also reported a higher incidence of suicidal ideation among current but not former smokers [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoking dose-response and suicidal ideation among young people in Nepal: a cross-sectional study

Sathian

Menezes

Asim

et al. 2020

Nepal J Epidemiology

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Background: Worldwide, tobacco smoking is a major risk factor for morbidity and early mortality among adult population. The present study aimed to find out the association between current smoking and suicidal ideation among young people in Nepal. Materials and Methods: A cross-sectional questionnaire-based survey was carried out among 452 youths from Pokhara, Nepal. The present study included both genders (age 18-24 years) who were smokers as well as non-smokers. Results: Across the study period, 452 participants were identified after matching for age, and sex (226 in the smoking group and 226 in the non-smoking group). The mean age of participants was 21.6±1.2 years and 58.8% were males. The overall rate of suicidal ideation in our cohort was 8.9%. Smokers were slightly more likely to report suicidal ideation than non-smokers (aOR 1.12). The risk of developing suicidal ideation was 3.56 (95% CI 1.26-10.09) times more in individuals who smoked greater than 3.5 cigarettes per week (p=0.01). Conclusion: The rate of suicidal ideation was slightly higher among smokers and a dose-response relationship was identified with the number of cigarettes smoked per week. Being aware of the link between smoking and suicidal ideation may help health care professionals working with young people to address more effectively the issues of mental well-being and thoughts about suicide.

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“…CBT has been proven to help reduce cravings and promote smoking cessation by changing participants’ thoughts and behaviors [ 24 ]. The CBT quitting method consists of several parts, generally including preparation before quitting smoking, starting quitting smoking, and maintaining or preventing the recurrence treatment stage [ 25 ]. CBT may be a good choice for people who want to quit smoking, especially for those who want to quit smoking through nondrug methods [ 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…The CBT quitting method consists of several parts, generally including preparation before quitting smoking, starting quitting smoking, and maintaining or preventing the recurrence treatment stage [ 25 ]. CBT may be a good choice for people who want to quit smoking, especially for those who want to quit smoking through nondrug methods [ 25 , 26 ]. Our previous study on “Happy Quit” SMS text message smoking cessation in China found that a CBT-based smoking cessation intervention can effectively improve the 24-week continuous smoking cessation rate [ 16 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Efficacy of a Cognitive Behavioral Therapy–Based Smartphone App for Smoking Cessation in China: Randomized Controlled Pilot Trial

Chen,

Tang,

et al. 2024

JMIR Form Res

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Background The overall prevalence of cigarette smokers in China is very high, and China’s total cigarette consumption makes up more than 40% of the world’s consumption. In view of the lack of smoking cessation services and social support in China and the effectiveness of mobile phone apps for quitting smoking in other countries, we carried out a smartphone app–based smoking cessation trial in China. Objective This study aimed to evaluate the efficacy of a cognitive behavioral therapy (CBT)–based smoking cessation smartphone app among smokers seeking treatment in China. Methods We conducted a randomized controlled, web-based pilot clinical trial in China between February 23 and June 27, 2021. Eligible participants were randomly assigned to the smoking cessation app intervention group or the control group in a ratio of 1:1. The intervention group received the CBT smoking cessation intervention using a smartphone app, and the control group received a “thank you” message. The intervention was 4 weeks long, and the patients were followed up for 4 weeks. The primary outcome was self-reported continuous smoking abstinence at week 4 after the quit date. The secondary outcomes included self-reported 7-day point prevalence of smoking abstinence; reduction of the number of cigarettes smoked per day at weeks 1, 2, 3, and 4; and program acceptability. Results A total of 973 people were recruited to quit smoking, of whom 262 completed basic information, 56 were excluded, and 206 were randomized and included in the final analysis. There were 189 (91.7%) men and 17 (8.3%) women, with an average age of 34.46 (SD 7.53) years and an average daily smoking rate of 15.93 (SD 7.10) cigarettes/day. We found 30 (29.7%) of the 101 participants in the intervention group and 7 (6.7%) of the 105 participants in the control group reported continuous smoking cessation after the quit date at week 4 (odds ratio 5.92, 95% CI 3.78-9.26; P<.001). The 7-day point prevalence abstinence rate of the intervention group varied from 42.6% (43/101) to 46.5% (47/101) after 1, 2, 3, and 4 weeks, while the control group varied from 18.1% (19/105) to 26.7% (28/105). Compared to the control group, continued smokers consumed 1.5-3.0 fewer cigarettes per day in the intervention group. The overall program got positive user feedback with a high satisfaction rate (66/87, 76%) and an average Mobile Application Rating Scale user version score of 3.46. Conclusions Our pilot study provided preliminary evidence that the CBT-based smoking cessation smartphone app led to improved smoking quit rates versus control in Chinese smokers. The study demonstrated the CBT-based smartphone app may be an effective and feasible digital treatment model to help smokers quit, which may improve smoking cessation service quality and accessibility in China. Trial Registration ClinicalTrials.gov NCT04421170; https://clinicaltrials.gov/study/NCT04421170 International Registered Report Identifier (IRRID) RR2-10.1136/bmjopen-2020-041985

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Are Smoking Cessation Treatments Associated with Suicidality Risk? An Overview

Cited by 5 publications

References 87 publications

Adverse events of smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes in the Food and Drug Administration Adverse Event Reporting System, 2004−2016

Adverse events of smoking cessation treatments (nicotine replacement therapy and non-nicotine prescription medication) and electronic cigarettes in the Food and Drug Administration Adverse Event Reporting System, 2004−2016

Cigarette smoking dose-response and suicidal ideation among young people in Nepal: a cross-sectional study

Preliminary Efficacy of a Cognitive Behavioral Therapy–Based Smartphone App for Smoking Cessation in China: Randomized Controlled Pilot Trial

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