Are Specific Allergen Sensitivities Inherited?

Misiak, Rana Tawil; Wegienka, Ganesa; Zoratti, Edward M.

doi:10.1007/s11882-010-0129-8

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…However, the question of whether specific allergen sensitization is inherited has been considered to be a complicated matter. Misiak et al 32 . reviewed the literature regarding this issue and concluded that specific allergen sensitization was influenced by both a genetic component and environmental exposure to allergen – with no clear-cut answer despite accounting for not only the complexity of allergy as a trait itself but also for the complexities of varying study methodologies as well as the evaluation of diverse populations and communities.…”

Section: Discussionmentioning

confidence: 99%

Identification of rare variants of allergic rhinitis based on whole genome sequencing and gene expression profiling: A preliminary investigation in four families

Zhang

Zhao

et al. 2019

World Allergy Organization Journal

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Background Despite the success of genome-wide association studies for allergic rhinitis (AR), no definitive causal variants have been identified, and a substantial portion of the heritability of the disease is yet to be discovered. Methods Four families, each with at least 1 parent and one child suffering from dust mite (DM) AR, were recruited, and whole-genome sequencing was performed on samples from 9 eligible individuals from these families. Conjoint analysis was performed for existing gene expression profiling data in the literature and the whole genome sequencing data obtained for these individuals; for presence of family-specific variants segregating with AR and the pathways involved. Similar analyses were also performed with data obtained for 96 sporadic house dust mite (HDM) AR patients and 96 healthy controls. Results Three rare variants in three genes (FLT1_c.603A > T; VEGFB_c.322A > C; and ITGA2_c.502+1G > A), which are involved in Focal Adhesion pathway, were identified in affected, but not unaffected, subjects in two families. VEGFB_c.322A > C and/or ITGA2_c.502+1G > A were further detected in all DM AR patients but not in any healthy individuals in 1 family; which was further investigated for members. The 3 identified variants were not found in any of the sporadic DM AR patients or healthy controls. Conclusion Despite the relatively small sample size, this study has identified several potentially functional rare variants in AR candidate genes, and it provides a platform for future work in larger numbers of families and sporadic individuals for a better understanding of the genetic basis of AR.

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Section: Discussionmentioning

confidence: 99%

Identification of rare variants of allergic rhinitis based on whole genome sequencing and gene expression profiling: A preliminary investigation in four families

Zhang

Zhao

et al. 2019

World Allergy Organization Journal

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“…"There is a lot of conflicting evidence," says Rana Tawil Misiak, a clinician who studies allergy at the Henry Ford Health System in Detroit, Michigan, and the lead author of a recent review of allergen specificity 1 . Misiak says that the best prospect of clarification lies in studies that are large enough to include genetic variants that have been associated with different allergies.…”

Section: Allergen-specific Profilesmentioning

confidence: 99%

Genetics: Seeking a gene genie

Westly

2011

Nature

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Is the built environment associated with morbidity and mortality? A systematic review of evidence from Germany

Schulz

Romppel

Grande

2018

International Journal of Environmental Health Research

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The empirical evidence on this relationship mainly comes from Anglo-American countries whereas evidence from Germany is only emerging. Our objective is to provide a narrative overview and critical appraisal of the existing empirical evidence on the relationship between the built environment and morbidity/mortality in Germany. We conducted a systematic literature search where we included all empirical studies that linked the built environment aspects with morbidity or mortality outcomes. Findings were summarized and critically evaluated according to the Newcastle Ottawa Scale. Eighteen studies met the inclusion criteria and underwent in-depth analysis. Findings indicate that traffic exposure and green space tend to be associated with acute respiratory symptoms but not with chronic respiratory conditions. Evidence was inconsistent for the role of infrastructural aspects and urbanicity. Our review confirms the well-established association between traffic and respiratory health. Yet, the consistency between self-reported and objective measures of respiratory health should be investigated in more detail.

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Are Specific Allergen Sensitivities Inherited?

Cited by 4 publications

References 14 publications

Identification of rare variants of allergic rhinitis based on whole genome sequencing and gene expression profiling: A preliminary investigation in four families

Identification of rare variants of allergic rhinitis based on whole genome sequencing and gene expression profiling: A preliminary investigation in four families

Genetics: Seeking a gene genie

Is the built environment associated with morbidity and mortality? A systematic review of evidence from Germany

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