Are sputum eosinophil cationic protein and eosinophils differently associated with clinical and functional findings of asthma?

Cianchetti, Silvana; Bacci, Elena; Ruocco, L; Pavia, T; Bartoli, Ml; Cardini, Cristina; Costa, Francesco; Franco, Antonella Di; Malagrinò, Laura; Novelli, Federica; Vagaggini, Barbara; Celi, Alessandro; Dente, Federico L.; Paggiaro, Pier Luigi

doi:10.1111/cea.12236

Cited by 14 publications

(13 citation statements)

References 31 publications

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“…84 In asthma, sputum eosinophil counts and ECP levels are typically increased but correlate only weakly with clinical markers of asthma severity. 85 Circulating levels of ECP have been associated with disease activity and peripheral eosinophil counts in EGPA. 86 …”

Section: Eosinophil-related Biomarkers In Egpamentioning

confidence: 98%

Eosinophils in vasculitis: characteristics and roles in pathogenesis

2014

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Eosinophils are multifunctional granular leukocytes that are implicated in the pathogenesis of a wide variety of disorders, including asthma, helminth infection, and rare hypereosinophilic syndromes. Although peripheral and tissue eosinophilia can be a feature of many types of small-vessel and medium-vessel vasculitis, the role of eosinophils has been best studied in eosinophilic granulomatosis with polyangiitis (EGPA), where eosinophils are a characteristic finding in all three clinical stages of the disorder. Whereas numerous studies have demonstrated an association between the presence of eosinophils and markers of eosinophil activation in the blood and tissues of patients with EGPA, the precise role of eosinophils in disease pathogenesis has been difficult to ascertain owing to the complexity of the disease process. In this regard, results of clinical trials using novel agents that specifically target eosinophils are providing the first direct evidence of a central role of eosinophils in EGPA. This Review focuses on the aspects of eosinophil biology most relevant to the pathogenesis of vasculitis and provides an update of current knowledge regarding the role of eosinophils in EGPA and other vasculitides.

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Section: Eosinophil-related Biomarkers In Egpamentioning

confidence: 98%

Eosinophils in vasculitis: characteristics and roles in pathogenesis

2014

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“…The literature is controversial regarding this issue, and the work by Cianchetti et al. contributes with a number of subjects higher than that in previous studies, but not with a clarification.…”

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confidence: 82%

“…A stepwise regression analysis showed weak, albeit significant, inverse correlations between eosinophil count and disease duration, and between ECP and airflow obstruction, suggesting that these biomarkers might identify different aspects of the disease. The explanation of these findings remains speculative given the observational nature of the study . The reason of longer duration of the disease in those patients with lower eosinophil counts might be simply due to the mildness of the disease in non‐eosinophilic subgroup, resulting in delay in seeking medical attention and/or in the first access to an asthma specialist.…”

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confidence: 96%

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More (on) airway eosinophilia in asthma

Maestrelli

2014

Clin Experimental Allergy

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“…Asthmatic patients were young or mid-life non-smoking female with typical asthmatic history and patients with COPD were middle-or older-aged heavy smokers with typical clinical history of COPD. Although asthma with Th2 inflammation consists major portion among asthmatics (4,5), there is an increasing appreciation of heterogeneity within asthma primarily on cluster analyses of clinical phenotypes and different responses to conventional treatments or targeted therapeutics (4,6).…”

Section: Introductionmentioning

confidence: 99%