Are Survival Rates Different for Young and Older Patients With Rectal Cancer?

O’Connell, Jessica; Maggard, Melinda A.; Liu, Jerome H.; Etzioni, David A.; Ko, Clifford Y.

doi:10.1007/s10350-004-0738-1

Cited by 121 publications

(83 citation statements)

References 15 publications

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“…Though rectal cancer has been reported to be uncommon (3.6%) in the young patients, in our series, there was not much difference between the two groups (44% in young and 45% in older). 15 As most of the colon cancers involved left side, in our population, screening sigmoidoscopy could be an effective tool for mass screening in high-risk people.…”

Section: Discussionmentioning

confidence: 85%

Comparison of Stage and Lymph Node Ratio in Young and Older Patients with Colorectal Cancer Operated in a Tertiary Hospital in Nepal

Ghimire

Singh

Kurlberg

et al. 2018

J Nepal Health Res Council

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Background: Colorectal cancer is being diagnosed more frequently in the young and it presents in an advanced stage. In TNM staging, stage depends on tumor size and number of positive nodes, which depend on location of tumor as well as the extent of dissection.The lymph node ratio is regarded as a more reliable marker for prognosis. In this study, we compare epidemiology of colorectal cancer in the young (<40 years) and older patients as well as the LNR. Methods:Patients with colorectal cancer operated at the Tribhuvan University Teaching Hospital, Kathmandu, Nepal for a period of 4 years (2012 -2016) were included in the study. Patients were grouped into young (≤ 40 years) and older (> 40 years) and clinic-pathological data such as site of lesion, clinical stage, and lymph node ratio were compared. Results:Of the 95 patients of colorectal cancer, 25 patients were of age ≤ 40 years (26%) and they had a higher median stage at diagnosis. In patients above 40 years, it was diagnosed at a relatively earlier stage. The mean number of positive nodes was 11.64 in younger patients whereas it was 18.34in those more than 40 years of age,but younger patients had higher lymph node ratio than elderly (0.31 vs 0.13) (P-value ≤ 0.005). Conclusions:Young patients with colorectal cancer tend to have more advanced disease. The lymph node metastasis and lymph node ratio tend to be higher in young patients.

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Section: Discussionmentioning

confidence: 85%

Comparison of Stage and Lymph Node Ratio in Young and Older Patients with Colorectal Cancer Operated in a Tertiary Hospital in Nepal

Ghimire

Singh

Kurlberg

et al. 2018

J Nepal Health Res Council

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“…1 Although most cases of rectal carcinoma are now diagnosed at an earlier stage, partially owing to screening efforts, about 18% of cases are clinically diagnosed as locally advanced with evidence of tumours beyond the confines of the bowel wall. 2 In addition, about 5% of rectal carcinoma tumours are found to invade the urinary tract. 3 With the advent of total mesorectal excision for rectal carcinoma, several studies have demonstrated that negative surgical margin status is the most important prognostic factor for disease-free survival.…”

Section: Discussionmentioning

confidence: 99%

Total pelvic exenteration for rectal cancer: outcomes and prognostic factors

Domes

Colquhoun²,

Taylor³

et al. 2011

Can J Surg

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Background:To perform complete resection of locally advanced and recurrent rectal carcinoma, total pelvic exenteration (TPE) may be attempted. We identified disease-related outcomes and prognostic factors. Methods:We conducted a single-centre review of patients who underwent TPE for rectal carcinoma over a 10-year period. Results:We included 28 patients in our study. After a median follow-up of 35 months, 53.6% of patients were alive with no evidence of disease. The 3-year actuarial disease-free and overall survival rates were 52.2% and 75.1%, respectively. On univariate analysis, recurrent disease, preoperative body mass index greater than 30 and lymphatic invasion were poor prognostic factors for disease-free survival, and only lymphatic invasion predicted overall survival. Additionally, multivariate analysis identified lymphatic invasion as an independent poor prognostic factor for disease-free survival in this patient population with locally advanced and recurrent rectal carcinoma. Conclusion:Despite the significant morbidity, TPE can provide long-term survival in patients with rectal carcinoma. Additionally, lymphatic invasion on final pathology was an independent prognostic factor for disease-free survival.Contexte : Pour pratiquer une résection complète du cancer du rectum avancé au stade local et récidivant, on peut tenter une exentération pelvienne totale (EPT). Nous avons déterminé des résultats liés à la maladie et des facteurs de pronostic. Méthodes :Nous avons procédé à une étude unicentrique portant sur des patients qui ont subi une EPT pour un cancer du rectum au cours d'une période de 10 ans.

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“…1). When the tumor is confined to the colon (stages I and II), surgery is curative with a 5-year survival rate up to 80%; however, in the case of dissemination (nodal involvement, metastatic disease) the prognosis is dramatically reduced (2). Thus, the development of new diagnostic tools for the early detection of lesions is attractive.…”

Section: Introductionmentioning

confidence: 99%

Colonization of the Human Gut by E. coli and Colorectal Cancer Risk

Bonnet

Buc

Sauvanet

et al. 2014

Clinical Cancer Research

389

339

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Purpose: The intestinal microbiota is potentially involved in the development of colorectal carcinoma via various mechanisms. Escherichia coli are commensal bacteria of the human gut microbiota, but some pathogenic strains have acquired the ability to induce chronic inflammation and/or produce toxins, such as cyclomodulin, which could participate in the carcinogenesis process. Here, we analyzed the E. coli population associated with mucosa of patients with colon cancer in relation to clinicopathologic characteristics. We assessed carcinogenic properties of a colon cancer-associated E. coli strain in multiple intestinal neoplasia (Min) mice.Experimental design: Mucosa-associated or internalized E. coli were quantified and characterized from tumors and mucosa of patients with colon cancer and the healthy mucosa of diverticulosis controls. Min mice were inoculated with a colon cancer-associated E. coli strain (11G5). The number of colonic polyps was evaluated at 7 weeks after infection.Results: An increased level of mucosa-associated and internalized E. coli was observed in the tumors compared with normal tissue. A relationship between poor prognostic factors for colon cancer (tumornode-metastasis stage) and colonization of mucosa by E. coli was observed. Pathogenic cyclomodulinpositive E. coli strains were more prevalent on mucosa of patients with stages III/IV than those with stage I colon cancer. Proliferative index and E. coli colonization level of the mucosa distant from the tumor significantly correlated. Min mice infected with the E. coli strain 11G5 displayed a marked increase in the number of visible colonic polyps compared with controls.Conclusion: These findings support that pathogenic E. coli could be a cofactor in pathogenesis of colorectal cancer. Clin Cancer Res; 20(4); 859-67. Ó2013 AACR.

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Are Survival Rates Different for Young and Older Patients With Rectal Cancer?

Abstract: Although previous studies have found young rectal cancer patients to have poorer survival compared with older patients, this population-based study shows that young rectal cancer patients seem to have equivalent overall and stage-specific survival.

Cited by 121 publications

References 15 publications

Comparison of Stage and Lymph Node Ratio in Young and Older Patients with Colorectal Cancer Operated in a Tertiary Hospital in Nepal

Comparison of Stage and Lymph Node Ratio in Young and Older Patients with Colorectal Cancer Operated in a Tertiary Hospital in Nepal

Total pelvic exenteration for rectal cancer: outcomes and prognostic factors

Colonization of the Human Gut by E. coli and Colorectal Cancer Risk

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