Are the differences between estradiol and other estrogens merely semantical?

Hughes, CL

doi:10.1210/jcem.81.6.8964886

Cited by 5 publications

(2 citation statements)

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“…17β-Estradiol is one of the most powerful xenoestrogens being considered an endocrine disruptor (Dorabawila and Gupta 2005), which may interfere both human and wildlife endocrine systems (Ankley et al 1998;Birkett and Lester 2003;Ghiselli and Jardim 2007;Hughes 2007;Lintelmann et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Effects in Erythrocytes of Oreochromis niloticus Exposed to Nanograms-per-Liter Concentration of 17β-Estradiol (E2): An Assessment Using Micronucleus Test and Comet Assay

Sponchiado

Reynaldo

Andrade

et al. 2010

Water Air Soil Pollut

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Pharmacologically active substances used in the treatment of human and animal illnesses may usually enter the aquatic environment via effluents from sewage treatment plants, as they are not completely biodegraded or removed during waste water treatment. 17β-Estradiol genotoxicity was evaluated in Oreochromis niloticus (family Cichlidae) using micronucleus test, other nuclear abnormalities assessment, and the comet assay with erythrocytes. Fish were exposed to aqueous systems contaminated with 6 ng/L 17β-estradiol for three periods: 24 h, 48 h, and 10 days. The results showed that 17β-estradiol has genotoxic potential in different periods, since significant differences (P=0.036) were observed in the micronucleus frequencies of the 10-day exposure groups in relation to the control group. Also, the same was observed when comparing the nuclear abnormality frequencies (P=0.018) of the 24-h exposure group with the negative control group, and when using comet assay (P<0.001) for 48-h evaluations. The tested concentration of the 17β-estradiol gave rise to mutagenic and genotoxic effects on the blood cells of O. niloticus, therefore the substance being considered a clastogenic chemical contaminant on both acute and chronic exposures. The assessment using a combination of micronucleus test, nuclear abnormalities, and comet assays proved to be suitable and useful in the genotoxicity testing of 17β-estradiol at nanograms per liter.

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Section: Introductionmentioning

confidence: 99%

Genotoxic Effects in Erythrocytes of Oreochromis niloticus Exposed to Nanograms-per-Liter Concentration of 17β-Estradiol (E2): An Assessment Using Micronucleus Test and Comet Assay

Sponchiado

Reynaldo

Andrade

et al. 2010

Water Air Soil Pollut

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“…Plantderived isoflavonoids, coumestans, and ligands compete with estradiol with varying affinities to bind to estrogen receptors (ERs), induce transcription of estrogenresponsive genes (Kuiper et al 1998) and, depending on the outcome measured, either mimic or antagonize the action of steroidal estrogens (Hughes 1996). Humans are exposed to phytoestrogens through their diet, a major source being soy and soy-derived foods, which contain high levels of the isoflavone class of non-steroidal estrogenic compounds, genistein and daidzein (Martin et al 1978, Price & Fenwick 1985, Setchell & Cassidy 1999, de Kleijn et al 2001.…”

Section: Introductionmentioning

confidence: 99%

The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors

Usui¹,

Ikeda²,

Tagami³

et al. 2002

Journal of Endocrinology

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Some plant compounds or herb mixtures are popular alternatives to conventional therapies and contain organic compounds that bind to some nuclear receptors, such as the estrogen receptor (ER), to exert various biological effects. We studied the effect of various herbal extracts on ER and ER isoforms. One herbal extract, Rhei rhizoma (rhubarb), acts as an agonist to both ER and ER . The phytochemical lindleyin, a major component of rhubarb, might contribute to this estrogenic activity through ER and ER . 4-Hydroxytamoxifen, an ER antagonist, completely reversed the estrogenic activity of lindleyin.Lindleyin binds to ER in vitro, as demonstrated using a fluorescent polarization assay. The in vivo effect of rhubarb extract was studied using a vitellogenin assay system in the freshwater fish, Japanese medaka (Oryzias latipes). There were marked increases in serum vitellogenin levels in male medaka exposed to rhubarb extract. We conclude that lindleyin, a component of some herbal medicines, is a novel phytoestrogen and might trigger many of the biological responses evoked by the physiological estrogens.

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Phytoestrogens Alter Adrenocortical Function: Genistein and Daidzein Suppress Glucocorticoid and Stimulate Androgen Production by Cultured Adrenal Cortical Cells¹

Mesiano

Katz

Lee

et al. 1999

The Journal of Clinical Endocrinology & Metabolism

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Phytoestrogens influence a variety of biological processes. As 17beta-estradiol alters adrenocortical cell function, we examined whether the dietary phytoestrogens, genistein and daidzein, have related effects. In cultured human fetal and postnatal adrenal cortical cells, genistein and daidzein (both 0.4-40 micromol/L) decreased ACTH-stimulated cortisol production to basal levels (ED50, 1-4 micromol/L). In the adult adrenocortical cell line, H295, genistein, daidzein, and 17beta-estradiol (10 micromol/L) decreased cAMP-stimulated cortisol synthesis in a similar fashion. Neither genistein nor daidzein altered basal or ACTH-stimulated dehydroepiandosterone sulfate (DHEA-S) production in fetal adrenocortical cells, whereas in postnatal adrenocortical cells, DHEA and DHEA-S were markedly increased (ED50, 1-4 micromol/L). In H295 cells, basal and cAMP-stimulated DHEA production were similarly increased by the phytoestrogens and 17beta-estradiol. Genistein and daidzein did not affect the expression of steroid-metabolizing enzymes. However, genistein and daidzein specifically inhibited the activity of 21-hydroxylase (P450c21); the activities of other steroidogenic enzymes were not affected. Thus, phytoestrogens may decrease cortisol synthesis by suppressing the activity of P450c21 and, as a consequence, increase DHEA/DHEA-S synthesis by shunting metabolites away from the glucocorticoid synthetic pathway. Therefore, consumption of foods containing phytoestrogens may alter adrenocortical function by decreasing cortisol and increasing androgen production.

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Are the differences between estradiol and other estrogens merely semantical?

Cited by 5 publications

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Genotoxic Effects in Erythrocytes of Oreochromis niloticus Exposed to Nanograms-per-Liter Concentration of 17β-Estradiol (E2): An Assessment Using Micronucleus Test and Comet Assay

Genotoxic Effects in Erythrocytes of Oreochromis niloticus Exposed to Nanograms-per-Liter Concentration of 17β-Estradiol (E2): An Assessment Using Micronucleus Test and Comet Assay

The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors

Phytoestrogens Alter Adrenocortical Function: Genistein and Daidzein Suppress Glucocorticoid and Stimulate Androgen Production by Cultured Adrenal Cortical Cells¹

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Are the differences between estradiol and other estrogens merely semantical?

Cited by 5 publications

References 0 publications

Genotoxic Effects in Erythrocytes of Oreochromis niloticus Exposed to Nanograms-per-Liter Concentration of 17β-Estradiol (E2): An Assessment Using Micronucleus Test and Comet Assay

Genotoxic Effects in Erythrocytes of Oreochromis niloticus Exposed to Nanograms-per-Liter Concentration of 17β-Estradiol (E2): An Assessment Using Micronucleus Test and Comet Assay

The phytochemical lindleyin, isolated from Rhei rhizoma, mediates hormonal effects through estrogen receptors

Phytoestrogens Alter Adrenocortical Function: Genistein and Daidzein Suppress Glucocorticoid and Stimulate Androgen Production by Cultured Adrenal Cortical Cells1

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Phytoestrogens Alter Adrenocortical Function: Genistein and Daidzein Suppress Glucocorticoid and Stimulate Androgen Production by Cultured Adrenal Cortical Cells¹