Are there critical periods for brain growth in children born preterm?

Cooke, Richard

doi:10.1136/adc.2005.077438

Cited by 86 publications

(70 citation statements)

References 32 publications

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“…Several studies have demonstrated that short stature and a small head size are important predictors for subnormal intellectual performance (4,34,35). Our study showed that a small birth size in combination with the K1245 A-allele, was associated with the smallest HC in SGA subjects, and especially in short SGA subjects (A-allele carriers: K1.70 SDS).…”

Section: Discussionsupporting

confidence: 47%

The −G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children

Ester

Meurs

Arends

et al. 2009

European Journal of Endocrinology

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Context: Small for gestational age (SGA) subjects experience pre-and postnatal growth restriction, which might be influenced by polymorphisms in the IGF1 gene. The well-known K841(CA) n /192 bp polymorphism has been associated with birth size, cardiovascular disease, and IGF-1 levels, and is in linkage disequilibrium with the KG1245A single nucleotide polymorphism (SNP; rs35767). Objective: To associate the KG1245A SNP with head circumference (HC) and brain sparing (a greater head compared with height SDS) in short SGA and SGA catch-up subjects. Design: Gene association study. Patients: We studied 635 SGA subjects out of which 439 remained short and 196 had a postnatal height OK2.00 SDS. Measurements: The KG1245A SNP IGF1 gene polymorphism and head size. Results: All SGA subjects had a postnatal head size below the population mean (K1.01 SDS, P!0.001). Whereas SGA catch-up subjects had a head size that was in proportion with their height, short SGA subjects displayed extensive brain sparing (HC -height: SGA CU: 0.01 versus short SGA: 1.75 SDS, P!0.001). The most severely SGA born subjects had a 0.4 SDS smaller postnatal head size and 0.6 SDS less brain sparing when carrying the K1245 A-allele in contrast to G-allele carriers (PZ0.03). The association between the KG1245A SNP and head size remained significant after correction for birth weight and postnatal height SDS (PZ0.03). Birth weight, birth length and postnatal height SDS were not related with the -G1245A SNP. Conclusions: The K1245 A-allele of the IGF1 promoter SNP is associated with a small head size and less brain sparing in SGA born subjects and particularly those with the lowest birth weight.

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Section: Discussionsupporting

confidence: 47%

The −G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children

Ester

Meurs

Arends

et al. 2009

European Journal of Endocrinology

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“…10,24,25 Prenatal, and even more often postnatal, growth rates have been shown to be important for cognitive abilities, 10,23 and infants with both intrauterine and postnatal growth restriction are especially likely to have less favorable outcomes. 19,23,26,27 Rapid early weight gain is associated with improved cognitive outcome in infancy.…”

mentioning

confidence: 99%

“…Head size later in childhood has also been associated with cognition. 1,12,24 To gain a better understanding of the optimal postnatal growth and its relevance to the cognitive outcome of preterm infants, we need studies with comprehensive prospective follow-up of growth with several measurement points and standardized cognitive testing in a representative preterm population. Prenatal growth is an important factor to take into consideration, which can be achieved by separately analyzing SGA and non-SGA preterm infants.…”

mentioning

confidence: 99%

Antenatal and Postnatal Growth and 5-Year Cognitive Outcome in Very Preterm Infants

Leppänen

Lapinleimu

Lind³

et al. 2014

Pediatrics

109

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WHAT'S KNOWN ON THIS SUBJECT: Better postnatal growth, especially head growth, associates with better cognitive development in preterm infants. Suboptimal postnatal growth is more common in infants with poor antenatal growth than in infants with normal growth. WHAT THIS STUDY ADDS:Good weight gain and head circumference growth until 2 years was associated with better 5-year cognitive outcome in non-small for gestational age infants. Good head circumference growth around term age benefits the cognitive outcome of small for gestational age infants. abstract OBJECTIVES: To study how antenatal growth affects cognitive outcome in very preterm infants and to determine whether there is an association between growth in any particular time period between birth and 5 years of age and cognitive outcome. Small for gestational age (SGA) and non-SGA infants were analyzed separately, because antenatal growth may affect postnatal growth. and 2006 who were treated at Turku University Hospital (n = 181) were followed. Weight, length, and head circumference (HC) of the infants were measured at 9 time points between birth and 5 years. The growth was determined as a z score change between measurement points. Cognitive development was assessed at 5 years of age with the Wechsler Preschool and Primary Scales of IntelligenceRevised. The association between growth and full-scale IQ (FSIQ) was studied. METHODS:RESULTS: Growth in length and height was not associated with 5-year cognitive outcome. However, weight (r = 0.18, P = .04) and HC growth (r = 0.25, P = .01) between birth and 2 years of corrected age correlated to FSIQ in non-SGA children. In SGA children, HC growth (r = 0.33, P = .03) around term age correlated to FSIQ. CONCLUSIONS:Cognitive outcome was similar in SGA and non-SGA very preterm infants. Growth affected cognition positively in both subgroups, but the critical time period was different. Drs Leppänen and Lind made substantial contributions to conception and design, acquired data, analyzed and interpreted data, and wrote and revised the manuscript; Drs Lapinleimu, Lehtonen, Haataja, and Rautava made substantial contributions to conception and design, analyzed and interpreted data, and wrote and revised the manuscript; Mr Matomäki carried out the statistical analyses, made substantial contributions to conception and design and interpretation of data, and wrote and revised the manuscript; and all authors approved the article to be published. www.pediatrics.org/cgi

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“…Эта часть разработана как сер-висная модель, включающая следующие элементы: индивидуальный план обслуживания/помощи семье, направленный на выявление специфических потреб-ностей и необходимых услуг для ребенка и поддерж-ку участия родителей в вопросах принятия решений; наличие координатора для облегчения взаимодей-ствия между различными сервисными службами; ин-теграция ребенка и семьи в общество; создание меж-ведомственных советов по координации сервисных служб; изменение плана по достижении ребенком возраста 3 лет; обеспечение обслуживания в условиях среды, где непосредственно находится ребенок [7][8][9].…”

Section: обзоры литературыunclassified

Premature birth as a medical social problem. Part 3. Methods of premature infants follow-up

Сахарова¹,

Keshishyan²,

Alyamovskaya³

2017

Ross. vestn. perinatol. pediatr.

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Are there critical periods for brain growth in children born preterm?

Cited by 86 publications

References 32 publications

The −G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children

The −G1245A IGF1 polymorphism is related with small head size and less brain sparing in small for gestational age born children

Antenatal and Postnatal Growth and 5-Year Cognitive Outcome in Very Preterm Infants

Premature birth as a medical social problem. Part 3. Methods of premature infants follow-up

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