M usculoskeletal pain and injury are experienced by workers across nearly all industries and occupations. How employers respond to prevent worker pain and injury has important implications for worker health and well-being as well as significant financial and organizational implications for employers. Musculoskeletal pain and injury is a major contributor to the global burden of disease (Safiri et al., 2021), and these disorders have contributed to a sizable increase in the number of Americans out of work due to disability (Franklin et al., 2015). Work-related musculoskeletal disorders (MSDs) alone have been estimated to cost from $45 billion to $54 billion annually in the United States (National Research Council and Institute of Medicine Panel on Musculoskeletal Disorders in the Workplace, 2001). In this chapter, we review issues and trends related to the prevention and management of pain and disability in the workplace, with a special emphasis on chronic and intermittent pain, organizational support and communication, job accommodation, return-to-work processes, and the changing nature of work.MSDs generally include all medical conditions affecting muscles, bones, and joints, including tendinitis, sprains and strains, osteoarthritis, carpal tunnel syndrome, neck and back pain, and other specific diagnoses and conditions. MSDs are quite common, and they increase in prevalence with age. The predominant symptom is pain, but MSDs can also cause joint stiffness, swelling, dull aches, and restricted movement. Back and neck symptoms are most common, but MSDs can also impact the upper and lower extremities.