Are Thyroid and Sex Hormone Ratios Predictive of Breast Cancer Risk? A Preliminary Study among A Cohort of Sri Lankan Breast Cancer Patients

Abstract

Purpose: The association of thyroid related diseases and sex hormones with breast cancer (BC) is reported with inconclusive results. 
 Objectives: The study was designed to analyze the thyroid/sex hormone ratios of BC patients. 
 Methodology: TSH, T3, T4, estrogen, progesterone and testosterone concentrations of newly diagnosed breast cancer patients (n=155) aged 30 to 75 years and age-matched normal controls (n=75) were analyzed. Thyroid: sex hormone ratios were calculated. Data on history of thyroid related diseases were collected.
 Results and Discussion: History of thyroid related diseases was significantly higher (p