Are two doses of misoprostol after mifepristone for early abortion better than one?

Coyaji, Kurus; Krishna, U.; Ambardekar, Shubha; Bracken, Hillary; Raote, Veena; Mandlekar, Ajita; Winikoff, Beverly

doi:10.1111/j.1471-0528.2006.01208.x

Cited by 29 publications

(23 citation statements)

References 25 publications

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“…For example, the proportion of women reporting vomiting and diarrhoea has varied between 0-49% and 0-43% respectively. 18,20,88,102 The incidence and severity of symptoms is influenced by the dose and route of administration of misoprostol; 88 gastrointestinal symptoms and fever are more common with oral administration. 88 We found that a similar proportion of women (~ 22%) having MTOP and STOP were still bleeding 2 weeks after the procedure, although more women in the MTOP group reported heavy blood loss.…”

Section: Side Effectsmentioning

confidence: 99%

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation (TOPS)

Robson

Kelly²,

Howel³

et al. 2009

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this publication, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable CD-ROM is also available (see below).Printed copies of HTA monographs cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our Despatch Agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeT he Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in t...

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Section: Side Effectsmentioning

confidence: 99%

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation (TOPS)

Robson

Kelly²,

Howel³

et al. 2009

Health Technol Assess

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“…Mifepristone and misoprostol were approved for use in April 2002. Clinical studies of medical abortion conducted in India have shown the method to be highly effective and acceptable to Indian women [1][2][3][4]. In 2008, more than 5 Indian companies marketed mifepristone and misoprostol products, and evidence suggests that sales are substantial and increasing [5].…”

Section: Introductionmentioning

confidence: 99%

Home administration of misoprostol for early medical abortion in India

Bracken

2009

Intl J Gynecology & Obste

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“…11 The success rate of taking a 48 hour interval between the medications ranges from 92-97%. 2,12 Crenin et al reported success rate of 24 hour regimen to be 98.1% and 96.9% in their studies carried out in 2004 and 2007. 19 In present study the success rate is100%.…”

Section: Discussionmentioning

confidence: 99%

“…The success rate of 48 hour interval ranges from 92-97%. 2,12 Crenin et al reported success rate of 24 hour regimens to be 98.1% and 96.9% Coege et al showed a higher percentage of women in 48 hr. interval group reported side effects such as nausea and vomiting after mifepristone and administration than women in 24 hr.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of evidence based regimen for medical abortion over conventional methods

Gopal

Ganamurali

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Medical abortion is a means of medical termination of pregnancy by drugs alone. This can be done upto 63 days using mifepristone and misoprostol tablets. For the conventional method, patient has to come to the hospital 3 times. In our study we reduced the interval between the drugs there by reducing the number of hospital visits. The objectives were to study the reduction of induction abortion interval following administration of evidence based regimen and to compare the proportion of patients developing complications in both the groups.Methods: It was a comparative study conducted at Department of Obstetrics and Gynecology, Govermnent MedicalCollege Kottayam, Kerala, India from May 2015 to November 2015.Results: The mean induction abortion interval in experimental group was 14.3 hours and in control group, it was 60.4 hours which was found to be statistically significant. Only 3 patients (7%) of experimental group had side effects whereas 12 patients. (17.4%) had side effects in the control group. Major side effects encountered were severe abdominal pain and severe bleeding per vaginum. Evidence based regimen consist of administration of mifepristone 200mg and vaginal misoprostol 600µg 6 hours later for termination of pregnancy up to 63 days could reduce the induction abortion interval by 46 hours and had less side effects.Conclusions: As it reduces the induction abortion Interval and complications we feel that the evidence based regimen for Medical Termination of Pregnancy is superior to the FDA approved regimen.

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Are two doses of misoprostol after mifepristone for early abortion better than one?

Cited by 29 publications

References 25 publications

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation (TOPS)

Randomised preference trial of medical versus surgical termination of pregnancy less than 14 weeks' gestation (TOPS)

Home administration of misoprostol for early medical abortion in India

Effectiveness of evidence based regimen for medical abortion over conventional methods

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