Are unimanual movements bilateral?

Chettouf, Sabrina; Rueda‐Delgado, Laura M.; Vries, Ralph de; Ritter, Petra; Daffertshofer, Andreas

doi:10.1016/j.neubiorev.2020.03.002

Cited by 47 publications

(48 citation statements)

References 176 publications

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“…This idea of decreasing the excitability of one hemisphere to promote the excitability of the other hemisphere is logical when we are improving unimanual skills, where cortical excitability is localised to one area (Gomes-Osman & Field-Fote, 2013). But with whole-body and complex movements balanced bilateral activation and effective communication between the hemispheres is required (Chettouf et al, 2020;Waller et al, 2008). Therefore, we opted not to use incongruent stimulation and instead apply anodal-tDCS bilaterally.…”

Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation does not improve performance in a whole-body movement task

Caesley

Sewell

Gogineni

et al. 2021

Preprint

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Research has investigated the use of non-invasive brain interventions, such as transcranial direct current stimulation (tDCS), to enhance motor learning and rehabilitation. Much research has shown that tDCS improves motor learning and that bilateral tDCS is more beneficial than unilateral tDCS in improving motor learning. However, past research has primarily utilised simple motor tasks in measuring motor skill learning. These are not ecologically reliable as whole-body movement is required for everyday activities. This study involved two experiments. Each experiment involved participants learning 12 Ballroom and Latin dance moves whilst undergoing tDCS. All participants underwent three sessions of tDCS, (unilateral, bilateral and sham), over three consecutive days. Participants in the first experiment (n=30) had stimulation to the primary motor cortex (PMC) and those in the second experiment (n=31) had stimulation to the dorsolateral prefrontal cortex (DLPFC). In each experiment, a baseline was taken before the training sessions and two outcome measures were taken; a day after the last training session and two weeks later. In each testing session participants’ dance ability was measured. Our results showed that bilateral tDCS impaired performance in both experiments. Unilateral stimulation impaired performance in the first experiment, and did not significantly improve performance any better than the sham stimulation in the second experiment. These results suggest that task complexity plays a crucial role when tDCS procedures are used to modulate motor performance and highlights possible limitations of tDCS in practice.

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Section: Discussionmentioning

confidence: 99%

Transcranial direct current stimulation does not improve performance in a whole-body movement task

Caesley

Sewell

Gogineni

et al. 2021

Preprint

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“…That is, contralateral M1 – in our case the left – projects to both the ipsilateral (right) PM1 and M1. As discussed in Chettouf et al (2020), unimanual movements are considered a special case of bimanual ones. The direction and location of both inhibition and facilitation appears to depend on the motor task that is performed – an increase in task complexity seems to be accompanied with more (efficient) communication between hemispheres.…”

Section: Discussionmentioning

confidence: 99%

“…It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted February 16, 2021. ; https://doi.org/10.1101/2021.02.15.431203 doi: bioRxiv preprint to be particularly visible during learning a motor task with distinct timing requirements that we here used to contrast groups of young and older healthy adults. Chettouf et al (2020). Three alternative models that may account for bilateral cortical activation during unimanual performance.…”

Section: Introductionmentioning

confidence: 99%

“…The prime interface for left/right interactions is the corpus callosum (CC), which is also known for its aging-related changes (Frederiksen and Waldemar, 2012; Langan et al, 2010; Sullivan et al, 2001; Sullivan and Pfefferbaum, 2006). In fact, the deterioration of CC may also affect uni-manual motor control, as there is accumulating evidence that proper unimanual performance entails the inhibition of ipsilateral motor areas (Chettouf et al, 2020; Daffertshofer et al, 2005; Ghacibeh et al, 2007; Gross et al, 2005; van Wijk et al, 2012; Vercauteren et al, 2008). Trans-callosal pathways are both inhibitory and excitatory (Daffertshofer et al, 2005; Swinnen, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…In a recent review we outlined a candidate scheme (Fig. 1) for the corresponding circuitry(Chettouf et al, 2020; Daffertshofer et al, 2005; Ghacibeh et al, 2007; Gross et al, 2005; van Wijk et al, 2012; Vercauteren et al, 2008), where during unimanual movements the contralateral M1 projects through the CC to excite its ipsilateral M1, while the same contralateral M1 also projects to the ipsilateral PM1. The latter has inhibitory cortico-cortical projections to M1 in the same hemisphere and, if properly timed, suppresses its activity stemming from contralateral M1.…”

Section: Introductionmentioning

confidence: 99%

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Effect of aging-related network changes on unimanual sensorimotor learning – a simultaneous EEG-fMRI study

Chettouf

Triebkorn

Daffertshofer

et al. 2021

Preprint

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Sensorimotor coordination requires orchestrated network activity mediated by inter- and intra-hemispheric, excitatory and inhibitory neuronal interactions. Aging-related structural changes may alter these interactions. Disbalancing strength and timing of excitation and inhibition may limit motor performance. This is particularly true during motor coordination tasks that have to be learned through practice. To investigate this, we simultaneously acquired electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) in two groups of healthy adults (young N=13: 20-25y and elderly N=14: 59-70y), while they were practicing a unimanual motor task. Both groups learned the task during brain scanning, which was confirmed by a 24h follow-up retention test. On average, quality of performance of older participants stayed significantly below that of the younger ones. Accompanying decreases in motor-event-related EEG-source beta band power (β, 15-30 Hz) were lateralized in both groups towards the contralateral side, albeit more so in younger participants. In the latter, the mean β-power during motor learning in bilateral pre-motor cortex (PM1) was significantly higher than in the older group. Combined EEG/fMRI analysis revealed positive correlations between fMRI signals and source-reconstructed β-amplitude time courses in contralateral and ipsilateral M1, and negative correlations in bilateral PM1 for both groups. The β-positive fMRI response in bilateral M1 might be explained by an increased cross-talk between hemispheres during periods of pronounced β-activity. During learning, the Rolandic β-power relative to rest was higher in bilateral PM1 in younger participants, suggesting less task-related beta band desynchronization in this (better performing) group. We also found positive correlations be-tween Rolandic β-amplitude and fMRI-BOLD in bilateral M1 and negative correlations bilateral in PM1. This indicates that increased β-amplitudes are associated with increased M1 ″activity″ (positive BOLD response) and decreased PM1 ″activity″ (negative BOLD response). Our results point at decreased pre-motor inhibitory inputs to M1 as possible source for increased interhemispheric crosstalk and an aging-related decline in motor performance.

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