Are venous thromboembolism risk assessment tools reliable in the stratification of microvascular risk following lower extremity reconstruction?

Geoghegan, Luke; Super, Jonathan; Machin, Matthew; Gimzewska, Madelaine; Onida, Sarah; Hettiaratchy, Shehan; Davies, Alun H.

doi:10.1016/j.jpra.2021.04.004

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…Both found no significant association between VTE risk and free flap failure following free tissue reconstruction of the lower extremities. Geoghegan et al noted how all their patients who underwent free tissue transfer were deemed ‘high risk’ of developing deep vein thrombosis (DVT) according to these tools at baseline [ 30 ], resulting in an inability to further stratify those who would develop microvascular thrombosis and those who would not. However, the use of risk stratification tools is an area of potential development in free flap surgery.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus Scalded Skin Syndrome-Induced Thrombosis Leading to Free Flap Complications: A Case Report and Review

Keating,

Yoo,

Lane-O'Neill

et al. 2024

Cureus

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Staphylococcal scalded skin syndrome (SSSS) is a clinical term used for a spectrum of blistering skin conditions induced by the epidermolytic toxins of the Staphylococcus aureus bacteria. The complications of SSSS include thrombosis; however, the pathophysiology of this is still poorly understood. We present a case of free anterolateral thigh (ALT) flap failure in a patient as a result of widespread flap thrombosis associated with staphylococcal scalded skin syndrome (SSSS). This is the first reported case of free flap failure associated with SSSS. Free flap failure due to acquired prothrombotic conditions, such as infection, is a rare and potentially under-reported phenomenon. This article aims to further explore the role of both thrombophilias and provoked thrombotic events in free flap failure. A review of the literature will also be presented, and cases of free flap failure in patients with infection-induced vascular complications will be summarised.

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Section: Discussionmentioning

confidence: 99%

Staphylococcus Scalded Skin Syndrome-Induced Thrombosis Leading to Free Flap Complications: A Case Report and Review

Keating,

Yoo,

Lane-O'Neill

et al. 2024

Cureus

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“…53 Geoghegan et al investigated the ability of VTE RAMs in predicting microvascular thrombosis following lower extremity free tissue transfer. 54 This study included 58 adult patients with lower extremity open fractures and associated soft tissue injury requiring free flap reconstruction. All patients in this study received mechanical prophylaxis in the form of Flowtron boots on the contralateral limb and chemoprophylaxis (enoxaparin 20 mg daily and ASA 75 mg) perioperatively.…”

Section: Upper and Lower Extremity Microvascular Reconstructionmentioning

confidence: 99%

Chemoprophylaxis and Management of Venous Thromboembolism in Microvascular Surgery

et al. 2023

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This review aims to highlight the common pharmacological and nonpharmacological interventions utilized for thromboprophylaxis as well as flap salvage in microsurgery. A literature review was conducted in PubMed/National Center for Biotechnology Information, Scopus, Web of Science, and MEDLINE databases. Articles with a focus on thromboprophylaxis in microsurgical procedures spanning head and neck surgery, breast and extremity microvascular reconstruction, deep venous thrombosis/pulmonary embolus in microvascular surgery, and flap thrombosis and salvage were included in this review. The majority of available evidence supports mechanical venous thromboembolism (VTE) prophylaxis in all patients undergoing microsurgery given the presence of multiple risk factors for VTE within this particular patient population. Based on the literature review, addition of VTE chemoprophylactic agents is beneficial and an algorithmic approach to thromboprophylaxis in microsurgery patients and management of patients with thrombosis based on literature review and senior authors' experience is recommended and outlined.

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Aspirin/enoxaparin-sodium/warfarin

2022

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Are venous thromboembolism risk assessment tools reliable in the stratification of microvascular risk following lower extremity reconstruction?

Cited by 3 publications

References 26 publications

Staphylococcus Scalded Skin Syndrome-Induced Thrombosis Leading to Free Flap Complications: A Case Report and Review

Staphylococcus Scalded Skin Syndrome-Induced Thrombosis Leading to Free Flap Complications: A Case Report and Review

Chemoprophylaxis and Management of Venous Thromboembolism in Microvascular Surgery

Aspirin/enoxaparin-sodium/warfarin

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