Are Vocal Alterations Caused by Smoking in Reinke's Edema in Women Entirely Reversible After Microsurgery and Smoking Cessation?

Martins, Regina Helena Garcia; Tavares, Elaine Lara Mendes; Pessin, Adriana Bueno Benito

doi:10.1016/j.jvoice.2016.06.012

Cited by 21 publications

(11 citation statements)

References 17 publications

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“…Likewise, vocal abuse and laryngo‐pharyngeal reflux (LPR) are often regarded as additional risk factors, albeit their separate impact remains unclear. Furthermore, a predominance in elderly females is reported, suggesting a contribution of the hormonal status 3–5 . Therapeutic recommendations are based on a cessation of these risk factors (smoking), a probatory treatment of LPR, and ultimately phonosurgery.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, a predominance in elderly females is reported, suggesting a contribution of the hormonal status. [3][4][5] Therapeutic recommendations are based on a cessation of these risk factors (smoking), a probatory treatment of LPR, and ultimately phonosurgery. The latter leads mostly to an improvement of dysphonia; however, it cannot restore the healthy state.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Pathophysiology of Reinke's Edema: The Cellular Impact of Cigarette Smoke and Vibration

et al. 2020

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Objectives To explore the isolated or combined effects of cigarette smoke extract (CSE) and vibration on human vocal fold fibroblasts (hVFF) in an in vitro setting in order to elucidate their influence in the pathophysiology of Reinke's edema (RE). Study design Immortalized hVFF were exposed to CSE or control medium under static or vibrational conditions. A phonomimetic bioreactor was used to deliver vibrational patterns to hVFF over a period of 5 days. Methods Cytotoxicity was quantified using a lactate dehydrogenase assay. We employed reverse transcription–quantitative polymerase chain reaction, enzyme‐linked immunosorbent assay, and Magnetic Luminex(R) assays (R&D Systems, Minneapolis, MN) to assess the influence on extracellular matrix production, fibrogenesis, inflammation, and angiogenesis. Results We observed significant changes induced by CSE alone (hyaluronic acid, matrix metalloproteinase 1, Interleukin‐8, cyclooxygenase [COX]1, COX2, vascular endothelial growth factor [VEGF]D), as well as settings in which only the combination of CSE and vibration led to significant changes (transforming growth factor beta 1, VEGFA, VEGFC). Also, CSE‐induced levels of COX2 were only significantly reduced when vibration was applied. Conclusion We were able to explore the cellular effects of CSE and vibration on hVFF by employing a phonomimetic bioreactor. Whereas cigarette smoke is generally accepted as a risk factor for RE, the role of vibration remained unclear as it is difficult to study in humans. Our data showed that some genes and proteins in the pathophysiological context of RE were only affected when CSE in combination with vibration was applied. Level of Evidence NA Laryngoscope, 131:E547–E554, 2021

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Pathophysiology of Reinke's Edema: The Cellular Impact of Cigarette Smoke and Vibration

et al. 2020

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“…Reinke's edema has an association with smoking, excessive vocal strain, and laryngo-pharyngeal reflux disease [2,3]. Its strong association with smoking is thought to be related to increased vascular permeability from the chemicals found in cigarettes [6][7][8]. Once a patient develops symptoms, the diagnosis is made by direct inspection of the vocal folds.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Post-Operative Airway Obstruction in A Patient with Reinke’s Edema

Russo¹,

Blaize²,

Mark³

et al. 2017

J Anesth Clin Res

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Here we present the case of a 64 year old female with a history of neck radiation and Reinke's edema that experienced unexpected respiratory failure after a sedation anesthetic. After the case terminated, the patient was noted to be hypoventilating and stridorous. Mask ventilation, laryngeal mask airway ventilation, and direct laryngoscopy failed. The patient was intubated with video laryngoscopy. Reinke's edema, a benign lesion characterized by swelling of the vocal folds, was thought to contribute to the difficulty in ventilating and intubating this patient. We present a discussion of Reinke's edema and its potential relevance to the practice of anesthesia.

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“…Estudos recentes mostraram que as anormalidades causadas pelo tabagismo no Edema de Reinke em mulheres não são totalmente reversíveis com a cirurgia e a cessação do tabagismo 14 . Quanto à concordância das análises vocal e laríngea, um estudo mostrou acorrer em cerca da metade dos casos estudos, somente 15 .…”

Section: Introductionunclassified

Relação entre avaliação vocal, acústica e qualidade de vida em voz de mulheres com diferentes graus de Edema de Reinke

et al. 2019

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Introdução: O Edema de Reinke caracteriza-se por um processo inflamatório crônico que acomete a camada superficial da lâmina própria da prega vocal. Atualmente, sua etiologia é atribuída ao tabagismo associado ao abuso vocal. Objetivo: Relacionar os dados das avaliações vocal, acústica e de qualidade de vida em voz com o grau do Edema de Reinke em mulheres. Método: Estudo observacional, analítico, transversal e prospectivo. Participaram 22 mulheres, com idades entre 45 e 78 anos (média 58,3), que foram submetidas à avaliação laringológica para observação das variáveis referentes ao grau do edema e a associação com outras lesões e/ou alterações laríngeas; avaliação perceptivo-auditiva da voz; análise acústica da voz; e auto avaliação vocal por meio do protocolo Qualidade de Vida em Voz (QVV). Os exames laringoscópicos e as amostras vocais foram analisados por juízes especialistas. Os dados obtidos foram analisados estatisticamente pelo teste de Mann-Whitney. Os sujeitos foram agrupados em dois grupos: Grupo 1 (G1) (edema grau 1) e Grupo 2 (G2) (edemas graus 2 e 3). Resultados: O G2 apresentou piores resultados do que o G1 quanto ao maior número de sintomas vocais; maior grau de desvio vocal na avaliação perceptivo-auditiva; resultados mais alterados nas medidas acústicas jitter, shimmer e proporção GNE; valores mais baixos em todos os domínios do QVV, indicando pior qualidade de vida. Conclusões: As características laringológicas referentes à progressão do Edema de Reinke estão diretamente relacionadas à piora dos parâmetros perceptivo-auditivos e acústicos da voz e a um maior impacto negativo da disfonia na qualidade de vida.

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Are Vocal Alterations Caused by Smoking in Reinke's Edema in Women Entirely Reversible After Microsurgery and Smoking Cessation?

Cited by 21 publications

References 17 publications

Exploring the Pathophysiology of Reinke's Edema: The Cellular Impact of Cigarette Smoke and Vibration

Exploring the Pathophysiology of Reinke's Edema: The Cellular Impact of Cigarette Smoke and Vibration

Case Report: Post-Operative Airway Obstruction in A Patient with Reinke’s Edema

Relação entre avaliação vocal, acústica e qualidade de vida em voz de mulheres com diferentes graus de Edema de Reinke

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