Are we crying Wolff? 3D printed replicas of trabecular bone structure demonstrate higher stiffness and strength during off-axis loading

Wood, Zach; Lynn, L.M.; Nguyen, Jack; Black, Margaret Arielle; Patel, Meha; Barak, Meir Max

doi:10.1016/j.bone.2019.08.002

Cited by 17 publications

(24 citation statements)

References 68 publications

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“…Additionally, there is limited quantitative comparison of mechanical properties of these material to organic tissue mechanical properties. Some research exists for heart valves and bone comparisons, but not for myocardium [1,2]. The work reported in this paper aims to quantify and compare application specific mechanical properties of Digital Anatomy 3D printing materials to equivalent porcine tissue properties.…”

Section: Introductionmentioning

confidence: 99%

Polyjet 3D printing of tissue-mimicking materials: how well can 3D printed synthetic myocardium replicate mechanical properties of organic myocardium?

Severseike

Lee

Brandon

et al. 2019

Preprint

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Anatomical 3-D printing has potential for many uses in education, research and development, implant training, and procedure planning. Conventionally, the material properties of 3D printed anatomical models have often been similar only in form and not in mechanical response compared to biological tissue. The new Digital Anatomy material from Stratasys utilizes composite printed materials to more closely mimic the mechanical properties of tissue. Work was done to evaluate Digital Anatomy myocardium under axial loading for comparison with porcine myocardium regarding puncture, compliance, suturing, and cutting performance.In general, the Digital Anatomy myocardium showed promising comparisons to porcine myocardium. For compliance testing, the Digital Anatomy was either within the same range as the porcine myocardium or stiffer. Specifically, for use conditions involving higher stress concentrations or smaller displacements, Digital Anatomy was stiffer. Digital Anatomy did not perform as strongly as porcine myocardium when evaluating suture and cutting properties. The suture tore through the printed material more easily and had higher friction forces both during needle insertion and cutting. Despite these differences, the new Digital Anatomy myocardium material was much closer to the compliance of real tissue than other 3D printed materials. Furthermore, unlike biological tissue, Digital Anatomy provided repeatability of results. For tests such as cyclic compression, the material showed less than two percent variation in results between trials and between parts, resulting in lower variability than tissue. Despite some limitations, the myocardium Digital Anatomy material can be used to configure structures with similar mechanical properties to porcine myocardium in a repeatable manner, making this a valuable research tool.

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Section: Introductionmentioning

confidence: 99%

Polyjet 3D printing of tissue-mimicking materials: how well can 3D printed synthetic myocardium replicate mechanical properties of organic myocardium?

Severseike

Lee

Brandon

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…For example, according to [31], the strength of the cancellous bone tissue can range from 0.15 to 13.7 MPa. Due to the difference in the age of trabeculae and other factors, the real structure of trabeculae is heterogeneous, and each of its fragments is unique, as discussed in [32]. The heterogeneity of the trabecular bone tissue significantly complicates the modeling, which is necessary, first of all, to assess the risk of bone fractures.…”

Section: Methodological Aspects Of Modeling Trabecular Bone Tissuementioning

confidence: 99%

“…. + absD (n) )/n (32) Equations ( 27)-( 30) can be determined analytically or numerically. Equation (31) shows the simplest case of using rate, acceleration and jerk to predict fracture, that is, it is assumed that dimensionless estimates of the rate effect, acceleration and jerk equally contribute to material fracture.…”

Section: Application Of the Damage Function And Its Derivatives To The Prediction Of Destrucmentioning

confidence: 99%

Damage Function of a Quasi-Brittle Material, Damage Rate, Acceleration and Jerk during Uniaxial Compression: Model and Application to Analysis of Trabecular Bone Tissue Destruction

Kolesnikov

2021

Symmetry

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A diversity of quasi-brittle materials can be observed in various engineering structures and natural objects (rocks, frozen soil, concrete, ceramics, bones, etc.). In order to predict the condition and safety of these objects, a large number of studies aimed at analyzing the strength of quasi-brittle materials has been conducted and presented in publications. However, at the modeling level, the problem of estimating the rate and acceleration of destruction of a quasi-brittle material under loading remains relevant. The purpose of the study was to substantiate the function of damage to a quasi-brittle material under uniaxial compression, determine the rate, acceleration and jerk of the damage process, and also to apply the results obtained to predicting the destruction of trabecular bone tissue. In accordance with the purpose of the study, the basic concepts of fracture mechanics and standard methods of mathematical modeling were used. The proposed model is based on the application of the previously obtained differentiable damage function without parameters. The results of the study are presented in the form of plots and analytical relations for computing the rate, acceleration and jerk of the damage process. Examples are given. The predicted peak of the combined effect of rate, acceleration and jerk of the damage process are found to be of practical interest as an additional criterion for destruction. The simulation results agree with the experimental data known from the available literature.

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“…Despite the utility of voxelated materials, there are a few quantitative comparisons of mechanical properties of the 3D printing materials to the actual organic materials, such as bone [14], heart valves [15], and myocardium [11]. For the practical applications of voxelated 3D printing materials, it is crucial to develop novel high precision material characterization techniques to evaluate the mechanical properties of 3D printed anatomical materials.…”

Section: Introductionmentioning

confidence: 99%

Manufacturing and Characterization of Hybrid Bulk Voxelated Biomaterials Printed by Digital Anatomy 3D Printing

et al. 2020

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The advent of 3D digital printers has led to the evolution of realistic anatomical organ shaped structures that are being currently used as experimental models for rehearsing and preparing complex surgical procedures by clinicians. However, the actual material properties are still far from being ideal, which necessitates the need to develop new materials and processing techniques for the next generation of 3D printers optimized for clinical applications. Recently, the voxelated soft matter technique has been introduced to provide a much broader range of materials and a profile much more like the actual organ that can be designed and fabricated voxel by voxel with high precision. For the practical applications of 3D voxelated materials, it is crucial to develop the novel high precision material manufacturing and characterization technique to control the mechanical properties that can be difficult using the conventional methods due to the complexity and the size of the combination of materials. Here we propose the non-destructive ultrasound effective density and bulk modulus imaging to evaluate 3D voxelated materials printed by J750 Digital Anatomy 3D Printer of Stratasys. Our method provides the design map of voxelated materials and substantially broadens the applications of 3D digital printing in the clinical research area.

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Are we crying Wolff? 3D printed replicas of trabecular bone structure demonstrate higher stiffness and strength during off-axis loading

Cited by 17 publications

References 68 publications

Polyjet 3D printing of tissue-mimicking materials: how well can 3D printed synthetic myocardium replicate mechanical properties of organic myocardium?

Polyjet 3D printing of tissue-mimicking materials: how well can 3D printed synthetic myocardium replicate mechanical properties of organic myocardium?

Damage Function of a Quasi-Brittle Material, Damage Rate, Acceleration and Jerk during Uniaxial Compression: Model and Application to Analysis of Trabecular Bone Tissue Destruction

Manufacturing and Characterization of Hybrid Bulk Voxelated Biomaterials Printed by Digital Anatomy 3D Printing

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