“…This results in downregulation of both oxytocin and prolactin receptors, due to continuous oxytocin incretion and suboptimal removal of the local inhibitory factor, so affecting both milk flow and production. As in other mammals, short feeds are essential in humans for maintaining effective milk ejection through the let‐down reflex, elicited by mechanical stimulation of nerve receptors of the nipple or by psychoemotional impulses, with pulsatile oxytocin incretion and intermittent receptor effect . As regard to the interval between feeds, it is accepted that an interfeed gap interval of almost 3 h is necessary for breasts refilling, driven by prolactin reflex .…”