Are we ready for the revision of the 14-day rule? Implications from Chinese legislations guiding human embryo and embryoid research

Xue, Yang; Liu, Shang

doi:10.3389/fcell.2022.1016988

Cited by 3 publications

(1 citation statement)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most pressing question regarding SCEM is whether they should be exempt from the so called "14-day rule" which limits in-vitro embryo development beyond this point. The 14-day rule was first proposed by The Ethics Advisory Board of the US Department of Health, Education, and Welfare in 1979, and then endorsed in the UK by the influential Warnock Report [20].…”

Section: Scem and The 14-day Rulementioning

confidence: 99%

Stem cell-derived embryo models: moral advance or moral obfuscation?

Gyngell,

Lynch,

Sawai

et al. 2024

J Med Ethics

View full text Add to dashboard Cite

Stem cell-derived embryo models (SCEMs) are model embryos used in scientific research to gain a better understanding of early embryonic development. The way humans develop from a single-cell zygote to a complex multicellular organism remains poorly understood. However, research looking at embryo development is difficult because of restrictions on the use of human embryos in research. Stem cell embryo models could reduce the need for human embryos, allowing us to both understand early development and improve assisted reproductive technologies. There have been several rapid advances in creating SCEMs in recent years. These advances potentially provide a new avenue to study early human development. The benefits of SCEMs are predicated on the claim that they are different from embryos and should, therefore, be exempt from existing regulations that apply to embryos (such as the 14-day rule). SCEMs are proposed as offering a model that can capture the inner workings of the embryo but lack its moral sensitivities. However, the ethical basis for making this distinction has not been clearly explained. In this current controversy, we focus on the ethical justification for treating SCEMs differently to embryos, based on considerations of moral status.

show abstract

Section: Scem and The 14-day Rulementioning

confidence: 99%

Stem cell-derived embryo models: moral advance or moral obfuscation?

Gyngell,

Lynch,

Sawai

et al. 2024

J Med Ethics

View full text Add to dashboard Cite

show abstract

How should China set ethical guardrails for medical research?

Xu,

Liu,

Shi

et al. 2023

J Med Ethics

View full text Add to dashboard Cite

‘Ethics first’ reform in China significantly changes the governance framework for the research of emerging technologies. The misapplication of human genome editing technology reflects the urgent need to reform the governance framework. Strengthening ethics governance in medical research has become a consensus in China, where legal and ethical reforms are proceeding in parallel. The protection of human dignity, the prevention of biosafety risks, as well as the regulation of technological crimes are at the core of the legal system, which has been embodied in numerous fundamental legislations following the CRISPR-babies incident. Establishing a national ethics committee to coordinate ethics governance, and reinforcing ethics review and external oversight are significant steps in ethical reform. Essentially, ethics governance requires implementing the basic concept of ‘ethics first’, focusing on forward-looking and preventive governance rather than delayed intervention, while maintaining openness and collaboration.

show abstract

Cilia and Nodal Flow in Asymmetry: An Engineering Perspective

Messmore,

Kassab,

Prather

et al. 2024

Crit Rev Biomed Eng

View full text Add to dashboard Cite

Over the past several years, cilia in the primitive node have become recognized more and more for their contribution to development, and more specifically, for their role in axis determination. Although many of the mechanisms behind their influence remain undocumented, it is known that their presence and motion in the primitive node of developing embryos is the determinant of the left-right axis. Studies on cilial mechanics and nodal fluid dynamics have provided clues as to how this asymmetry mechanism works, and more importantly, have shown that direct manipulation of the flow field in the node can directly influence physiology. Although relatively uncommon, cilial disorders have been shown to have a variety of impacts on individuals from chronic respiratory infections to infertility, as well as <i>situs inversus</i> which is linked to congenital heart disease. After first providing background information pertinent to understanding nodal flow and information on why this discussion is important, this paper aims to give a review of the history of nodal cilia investigations, an overview of cilia mechanics and nodal flow dynamics, as well as a review of research studies current and past that sought to understand the mechanisms behind nodal cilia's involvement in symmetry-breaking pathways through a biomedical engineering perspective. This discussion has the additional intention to compile interdisciplinary knowledge on asymmetry and development such that it may encourage more collaborative efforts between the sciences on this topic, as well as provide insight on potential paths forward in the field.

show abstract

Are we ready for the revision of the 14-day rule? Implications from Chinese legislations guiding human embryo and embryoid research

Cited by 3 publications

References 56 publications

Stem cell-derived embryo models: moral advance or moral obfuscation?

Stem cell-derived embryo models: moral advance or moral obfuscation?

How should China set ethical guardrails for medical research?

Cilia and Nodal Flow in Asymmetry: An Engineering Perspective

Contact Info

Product

Resources

About