Are Women with Polycystic Ovary Syndrome at an Increased Risk of Pregnancy-Induced Hypertension and/or Preeclampsia?

Fridström, Margareta; Nisell, Henry; Sjöblom, Peter; Hillensjø, Torbjörn

doi:10.3109/10641959909009612

Cited by 61 publications

(50 citation statements)

References 9 publications

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“…Likewise, logistic regression indicated that women undergoing poor-quality embryo transfer are not at increased risk for pregnancy complications after adjusting for potential confounding factors. A recent meta-analysis indicated a strong relationship between pregnancy complications and PCOS [24]; several studies support this finding [25,26]. Therefore, adverse outcomes are related to assisted reproduction technology, but also patient-related factors [27,28].…”

Section: Discussionmentioning

confidence: 86%

Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?

Zhu

Lian

et al. 2014

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 86%

Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?

Zhu

Lian

et al. 2014

J Assist Reprod Genet

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“…However, pre-eclampsia was only found to be more frequent in the insulin resistant PCOS women and not in the non-insulin-resistant PCOS group when compared to controls. Earlier reports [8,[13][14][15] have shown hypertensive pregnancy complications to be more frequent in PCOS women than controls. In some of these reports the confounding effect of parity GDM in Insulin-Resistant PCOS Women has not been accounted for [13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Fridstrøm et al [8] have recently shown that there were differences in BMI and blood glucose levels during pregnancy between PCOS and control groups. Since the blood glucose levels and birth weights were similar in the two groups the authors concluded that hyperinsulinemia should be of minor importance in terms of pregnancy outcome.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Insulin Resistance on Pregnancy Complications and Outcome in Women with Polycystic Ovary Syndrome

Bjercke

Dale

Tanbo

et al. 2002

Gynecol Obstet Invest

125

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The aim of the study was to determine the risk of developing gestational diabetes mellitus (GDM) and pregnancy-induced hypertension (PIH)/pre-eclampsia in a cohort of pregnant women with the polycystic ovary syndrome (PCOS) and known insulin sensitivity status. Pregnancies and neonatal outcome were recorded in a prospective cohort study comprising 29 non-insulin-resistant PCOS women, 23 insulin-resistant PCOS women and a control group of 355 women who had conceived after assisted reproduction. Hypertension, pre-eclampsia and GDM were recorded as well as pregnancy duration, method of delivery and birth weight. The frequency of hypertension was significantly elevated in PCOS women (11.5%) compared to controls (0.3%), p < 0.01. However, the frequency of pre-eclampsia was significantly elevated only in the insulin resistant PCOS women (13.5%) compared to controls (7.0%), p < 0.02. GDM was significantly more frequent in PCOS women (7.7%) than controls (0.6%), p < 0.01. Insulin resistance prior to pregnancy, determined by continuous infusion of glucose with model assessment (CIGMA) test, did not further increase the frequency of GDM. Newborns from PCOS pregnancies were significantly more often delivered by Caesarean section than controls (40.3 vs. 27.3%, p < 0.05) and transferred to neonatal intensive care unit more often than controls (19.2 vs. 9.0%, p < 0.01). Thus we show that the frequencies of pre-eclampsia and GDM are increased in PCOS pregnancies.

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“…1,2 The impact that the syndrome has on human reproduction does not only include anovulatory infertility, but also detrimental effects on oocyte [3][4][5][6] and embryo 7 quality, endometrial receptivity, 8,9 and pregnancy development. 10 Retrospective [11][12][13][14][15] and prospective [16][17][18] noncontrolled data designated PCOS as a risk factor for increased incidence of complications throughout pregnancy. A recent meta-analysis 10 confirmed an increased risk for gestational diabetes mellitus (DM), pre-eclampsia (PE), pregnancyinduced hypertension (PIH), and preterm birth.…”

Section: Introductionmentioning

confidence: 99%

Uterine blood flow in pregnant patients with polycystic ovary syndrome: relationships with clinical outcomes

Palomba

Falbo

Russo

et al. 2010

BJOG

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Objective To study the impedance to blood flow through the uterine artery in pregnant women with polycystic ovary syndrome (PCOS), and to evaluate its predictive value for adverse pregnancy and perinatal outcomes in this population.Design Prospective case-control study.Setting Academic Departments of Obstetrics and Gynaecology in Italy.Population Seventy-three pregnant women with ovulatory PCOS (PCOS group) and 73 age-and body mass index-matched healthy pregnant controls (control group).Methods Serial Doppler velocimetry measurements of the uterine artery.Main outcome measures Blood flow impedance indices and pregnancy/perinatal outcomes.Results A significantly (P < 0.05) higher rate of subjects with abnormal velocimetry findings was observed in the PCOS group than in the control group. In the PCOS group, the pulsatility index (PI) at first (P = 0.042) and mid-second (P = 0.039) trimesters of pregnancy, and bilateral notch at first (P = 0.025) and mid-second (P = 0.007) trimesters of pregnancy, were the strongest independent predictors of adverse outcomes. Conversely, in the control group, PI at the first trimester of pregnancy was a predictor of adverse outcomes only when combined with bilateral notch (P = 0.042), whereas at mid-second trimester of pregnancy PI (P = 0.033) and bilateral notch (P = 0.048) were independent predictors of adverse outcomes.Conclusions Uterine artery Doppler indices are more commonly altered in pregnant patients with PCOS than in controls, showing a high predictive value for abnormal pregnancy/perinatal outcomes.

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Are Women with Polycystic Ovary Syndrome at an Increased Risk of Pregnancy-Induced Hypertension and/or Preeclampsia?

Cited by 61 publications

References 9 publications

Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?

Does IVF cleavage stage embryo quality affect pregnancy complications and neonatal outcomes in singleton gestations after double embryo transfers?

Impact of Insulin Resistance on Pregnancy Complications and Outcome in Women with Polycystic Ovary Syndrome

Uterine blood flow in pregnant patients with polycystic ovary syndrome: relationships with clinical outcomes

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