"Are you depressed?" Screening for depression in the terminally ill

Chochinov, Harvey Max; Wilson, Keith G.; Enns, Murray W.; Lander, Sheila

doi:10.1176/ajp.154.5.674

Cited by 419 publications

(35 citation statements)

References 17 publications

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“…The respective tool has to be suitable not only for differentiation between depression and "quite normal" psychological distress of patients coping with cancer diagnosis but also for avoiding misattribution of symptoms of the tumor disease to depression [20]. Unfortunately studies on the predictive value of the different screening tools are sparse [29,30]. The basic structures of the established depression assessment tools are mainly diagnostic interviews, patient self-report forms or observer ratings [31].…”

Section: Discussionmentioning

confidence: 99%

“…The advantage of structured clinical interviews is undoubted, but they have to be conducted by skilled staff and therefore require enormous amounts of resources [31]. Patient self-report screening inventories are brief enough and therefore more useful in routine application in cancer patients [30]. Furthermore, self-report forms are supposed to be more sensitive to identify significant functional impairment during follow up [29].…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic cancer and depression: myth and truth

Mayr

Schmid

2010

BMC Cancer

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BackgroundVarious studies reported remarkable high incidence rates of depression in cancer patients compared with the general population. Pancreatic cancer is still one of the malignancies with the worst prognosis and therefore it seems quite logical that it is one of the malignancies with the highest incidence rates of major depression.However, what about the scientific background of this relationship? Is depression in patients suffering from pancreatic cancer just due to the confrontation with a life threatening disease and its somatic symptoms or is depression in this particular group of patients a feature of pancreatic cancer per se?DiscussionSeveral studies provide evidence of depression to precede the diagnosis of pancreatic cancer and some studies even blame it for its detrimental influence on survival. The immense impact of emotional distress on quality of life of cancer patients enhances the need for its early diagnosis and adequate treatment. Knowledge about underlying pathophysiological mechanisms is required to provide the optimal therapy.SummaryA review of the literature on this issue should reveal which are the facts and what is myth.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pancreatic cancer and depression: myth and truth

Mayr

Schmid

2010

BMC Cancer

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“…In a busy oncology practice where time is limited, a single question: “Do you often feel sad and depressed?” may be an adequate screen. 82,83 Others have reported, however, that this simplified method may miss a significant proportion of patients who are depressed. 84 …”

Section: Psychological Statementioning

confidence: 99%

Geriatric Assessment in Older Patients with Breast Cancer

Klepin¹,

Mohile²,

Hurria³

2009

J Natl Compr Canc Netw

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Most cases of breast cancer are diagnosed in older adults. Compared with younger women, older women as a group are at increased risk for breast-cancer-specific mortality and at higher risk for treatment-associated morbidity as well. At the same time, older women are less likely to be offered preventive care or adjuvant therapy for this disease. There are major gaps in evidence regarding the optimal evaluation and treatment of older women with breast cancer due to significant under-representation in clinical trials. Chronologic age alone is an inadequate predictor of treatment tolerance and benefit in this heterogeneous population. Multiple issues uniquely associated with aging have an impact on cancer care, including functional impairment, comorbidity, social support, cognitive function, psychological state, and financial stress. Applying geriatric principles and assessment to this older adult population would inform decision-making, by providing estimates of life expectancy and identifying individuals most vulnerable to morbidity. Ongoing research is seeking to identify which assessment tools can best predict outcomes in this population, and thus guide us in tailoring treatments to maximize benefits in older adults with breast cancer.

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“…Exclusion criteria included reporting to have been diagnosed by a psychiatrist or a psychologist with major mental disorders including major depressive disorder, bipolar disorder, psychotic disorder or PTSD. Similar single-item screening is a quick means to screen for mental disorders and has been proven to be valid (e.g., Chochinov et al, 1997; Farvolden et al, 2003; Donker et al, 2009). In addition, exclusion criteria included scoring higher than 30 on the PTSD Checklist for DSM-5 (Weathers et al, 2013), as sum scores of 31 or higher indicate probable PTSD (cf.…”

Section: Methodsmentioning

confidence: 99%

Parental Post-traumatic Stress Disorder Symptoms Are Related to Successful Aging in Offspring of Holocaust Survivors

et al. 2017

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A fascinating, yet underexplored, question is whether traumatic events experienced by previous generations affect the aging process of subsequent generations. This question is especially relevant for offspring of Holocaust survivors (OHS), who begin to face the aging process. Some preliminary findings point to greater physical dysfunction among middle-aged OHS, yet the mechanisms behind this dysfunction need further clarification. Therefore, the current studies assess aging OHS using the broad-scoped conceptualization of successful aging, while examining whether offspring successful aging relates to parental post-traumatic stress disorder (PTSD) symptoms and offspring’s secondary traumatization symptoms. In Study 1, 101 adult offspring (mean age = 62.31) completed measures of parental PTSD, secondary traumatization, as well as successful aging indices – objective (medical conditions, disability and somatic symptoms) and subjective (perceptions of one’s aging). Relative to comparisons and OHS who reported that none of their parents suffered from probable PTSD, OHS who reported that their parents suffered from probable PTSD had lower scores in objective and subjective measures of successful aging. Mediation analyses showed that higher level of secondary traumatization mediated the relationship between parental PTSD and less successful aging in the offspring. Study 2 included 154 dyads of parents (mean age = 81.86) and their adult offspring (mean age = 54.48). Parents reported PTSD symptoms and offspring reported secondary traumatization and completed measures of objective successful aging. Relative to comparisons, OHS whose parent had probable PTSD have aged less successfully. Once again, offspring secondary traumatization mediated the effect. The findings suggest that parental post-traumatic reactions assessed both by offspring (Study 1) and by parents themselves (Study 2) take part in shaping the aging of the subsequent generation via reactions of secondary traumatization in the offspring. The studies also provide initial evidence that these processes can transpire even when offspring do not have probable PTSD or when controlling offspring anxiety symptoms. Our findings allude to additional behavioral and epigenetic processes that are potentially involved in the effect of parental PTSD on offspring aging, and further imply the need to develop interdisciplinary interventions aiming at promoting successful aging among offspring of traumatized parents.

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"Are you depressed?" Screening for depression in the terminally ill

Abstract: Objective: This study compared the performance of four brief screening measures for depression

Cited by 419 publications

References 17 publications

Pancreatic cancer and depression: myth and truth

Pancreatic cancer and depression: myth and truth

Geriatric Assessment in Older Patients with Breast Cancer

Parental Post-traumatic Stress Disorder Symptoms Are Related to Successful Aging in Offspring of Holocaust Survivors

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