Members of stigmatized groups, including lesbian, gay, bisexual, transgender, or queer-identifying (LGBTQ+) individuals, face greater vulnerability to infectious diseases, such as HIV/AIDS, coronavirus disease (COVID-19), and monkeypox, than non-stigmatized groups. Stigma can impact LGBTQ+ people’s access to health resources and can lead to discrimination. Risk communication messages for LGBTQ+ communities can also activate stereotypes and de-incentivize positive health behaviors. This vulnerability became clear for already heavily stigmatized LGBTQ+ people living in South Korea during the COVID-19 pandemic. As governments and media outlets communicated the sites of COVID-19 outbreaks, they shared details about transmission in LGBTQ+ spaces (e.g., gay nightclubs, bathhouses) that activated stereotypes about health, risk, and identity. LGBTQ+ individuals in South Korea subsequently experienced intersectional stigma related to gender, sexuality, and COVID-19. Since little research has examined intersectional stigma with COVID 19, the current study used in-depth interviews (N = 21) to examine the intersectional stigma and discrimination that LGBTQ+ communities experienced before and after the COVID-19 outbreak in Korea. Also, this study investigated risk communication that can help reduce and overcome stigmatization and thus encourage LGBTQ+ individuals to get tested, traced, and treated. Results revealed that reducing stigma is critical to encourage stigmatized groups to engage in infectious disease testing and treatment. Implications for public health are discussed. Highlights •LGBTQ+ people in South Korea experienced intersectional stigma with COVID-19•Anonymized testing procedures can reduce stigmatization and encourage testing•Health authorities can partner, consult, and collaborate with stigmatized groups•Health authorities can use trusted in-group messengers and messages with compassion•Governments should proactively develop anti-discrimination policies