Are young women with Turner syndrome at greater risk of coronary artery disease?

Kozłowska−Wojciechowska, Małgorzata; Jeż, Wacław; Zdrojewski, Tomasz; Chwojnicki, Kamil

doi:10.1097/01.hjr.0000216545.99807.fd

Cited by 18 publications

(10 citation statements)

References 13 publications

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“…Also in the US study, the decrease in HDL was accompanied by a decrease in triglycerides (8). As women with TS in general have an unfavorable cardiovascular risk profile, this may be an important issue (33).…”

Section: Discussionmentioning

confidence: 82%

Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome

Freriks

Sas

Traas

et al. 2013

European Journal of Endocrinology

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Objective: Short stature is a prominent feature of Turner syndrome (TS), which is partially overcome by GH treatment. We have previously reported the results of a trial on the effect of oxandrolone (Ox) in girls with TS. Ox in a dose of 0.03 mg/kg per day (Ox 0.03) significantly increased adult height gain, whereas Ox mg/kg per day (0.06) did not, at the cost of deceleration of breast development and mild virilization. The aim of this follow-up study in adult participants of the pediatric trial was to investigate the long-term effects of previous Ox treatment. Design and methods: During the previous randomized controlled trial, 133 girls were treated with GH combined with placebo (Pl), Ox 0.03, or Ox 0.06 from 8 years of age and estrogen from 12 years. Sixtyeight women (Pl, nZ23; Ox 0.03, nZ27; and Ox 0.06, nZ18) participated in the double-blind followup study (mean age, 24.0 years; mean time since stopping GH, 8.7 years; and mean time of Ox/Pl use, 4.9 years). We assessed height, body proportions, breast size, virilization, and body composition. Results: Height gain (final minus predicted adult height) was maintained at follow-up (Ox 0.03 10.2 G4.9 cm, Ox 0.06 9.7G4.4 cm vs Pl 8.0G4.6 cm). Breast size, Tanner breast stage, and body composition were not different between groups. Ox-treated women reported more subjective virilization and had a lower voice frequency. Conclusion: Ox 0.03 mg/kg per day has a beneficial effect on adult height gain in TS patients. Despite previously reported deceleration of breast development during Ox 0.03 treatment, adult breast size is not affected. Mild virilization persists in only a small minority of patients. The long-term evaluation indicates that Ox 0.03 treatment is effective and safe.European Journal of Endocrinology 168 91-99

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Section: Discussionmentioning

confidence: 82%

Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome

Freriks

Sas

Traas

et al. 2013

European Journal of Endocrinology

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“…La disección aórtica (DAo) es una complicación rara, que suele ser fatal en caso de no intervenirse. Tiene una incidencia estimada de 40 casos cada 10.000 pacientes (6) . Histopatológicamente se ha observado la presencia de necrosis quística de la capa media vascular, a su vez, se constató la presencia de alteración en elasticidad aórtica similares a lo observado en el síndrome de Marfan (7,8) .…”

Section: Discussionunclassified

Disección aórtica asintomática en una paciente con síndrome de Turner, válvula aórtica bicúspide y recoartación aórtica

Orellano¹,

Casella²,

Spina³

2020

Rev Ecocar Pract (RETIC)

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Se presenta el caso de una paciente de 47 años con síndrome de Turner, portadora de válvula aórtica bicúspide y antecedente de cirugía por coartación aórtica en la infancia, a quien se descubre durante un estudio de rutina una disección de la aorta ascendente asociada a insuficiencia aórtica severa secundaria a prolapso de dos de las valvas y a recoartación aórtica. El síndrome de Turner se asocia con complicaciones cardiovasculares potencialmente graves. El seguimiento clínico y con técnicas de imagen es fundamental para intentar prevenirlas

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“…The greatest risk factor for CAD in the TS population appears to be hypertension, a risk factor for aortic dissection as well. 50,51 In a study of 75 children with TS, 52 17% had diastolic and 21% had systolic blood pressure above the 95th percentile for age and sex. In addition, more than half of the girls had less than the normal 10% reduction in nocturnal systolic blood pressure.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

“…There are fewer smokers in the TS population than the general population and most studies have not found an increase in metabolic risk factors such as glucose, lipid, and, fibrinogen levels. The greatest risk factor for CAD in the TS population appears to be hypertension, a risk factor for aortic dissection as well 50,51 . In a study of 75 children with TS, 52 17% had diastolic and 21% had systolic blood pressure above the 95th percentile for age and sex.…”

Section: Turner Syndrome–specific Considerations For Estrogen Replacementioning

confidence: 99%

Moving Toward an Understanding of Hormone Replacement Therapy in Adolescent Girls

Davenport

2008

Annals of the New York Academy of Sciences

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Turner syndrome (TS) is a relatively common disorder of phenotypic females caused by loss of all or part of the second sex chromosome. Most individuals with TS have short stature and gonadal dysgenesis and are at risk for many other medical and learning problems. In the 45,X ovary, germs cells multiply quite normally during fetal development, but there is accelerated atresia of oocytes in the second half of pregnancy that produces gonadal insufficiency by birth. In girls with other karyotypes, especially those mosaic for 45,X/46,XX, gonadal function may be normal or near-normal. In this chapter, management goals for gonadal insufficiency in girls with TS are presented. The effects of estrogen deficiency and its replacement on three specific problems associated with TS-short stature, cardiovascular disease, and developmental differences in brain structure and function-are explored. General guidelines for estrogen replacement therapy using transdermal estrogen, the most physiologic option, are provided and future research goals are outlined.

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Are young women with Turner syndrome at greater risk of coronary artery disease?

Abstract: Women with Turner syndrome constitute a group at higher cardiovascular risk. This group of women requires effective preventative medicine from the earliest age.

Cited by 18 publications

References 13 publications

Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome

Long-term effects of previous oxandrolone treatment in adult women with Turner syndrome

Disección aórtica asintomática en una paciente con síndrome de Turner, válvula aórtica bicúspide y recoartación aórtica

Moving Toward an Understanding of Hormone Replacement Therapy in Adolescent Girls

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