Are Zn(ii) pincer complexes efficient apoptosis inducers? a deep insight into their activity against A549 lung cancer cells

Abstract

To expand the array of chemotherapeutic drugs, the earth-abundant metal complexes are found to be the future direction. In this regard, new zinc(II) complexes 1 – 3 of 8-aminoquinoline based...

Deciphering the Mechanism of MRSA Targeting Copper(II) Complexes of NN2 Pincer-Type Ligands

“…Mixing 8-aminoquinoline and 2-bromoacetyl bromide in the presence of triethylamine, the precursor 2-bromo- N -(quinolin-8-yl)­acetamide was synthesized . Further, the desired ligands L1 (H)– L3 (H) were synthesized by the reaction of 2-bromo- N -(quinolin-8-yl)­acetamide with corresponding secondary amines .…”

“…Mixing 8-aminoquinoline and 2-bromoacetyl bromide in the presence of triethylamine, the precursor 2-bromo- N -(quinolin-8-yl)­acetamide was synthesized . Further, the desired ligands L1 (H)– L3 (H) were synthesized by the reaction of 2-bromo- N -(quinolin-8-yl)­acetamide with corresponding secondary amines . Then the corresponding Cu­(II) complexes 1 – 3 have been isolated by mixing the methanolic solution of equivalent quantities of ligands with CuBr 2 and triethylamine at room temperature.…”

“…2-Bromo- N -(quinolin-8-yl)­acetamide, the precursor for the ligand synthesis as well as the ligand, L1 (H), was synthesized with slight modifications from the previously reported procedures . The same procedure was executed for the synthesis of L2 (H) and L3 (H) by using the corresponding secondary amines.…”