Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

Tey, Shu-Leei; Li, Chi‐Ying; Lin, Li‐Wei; Chang, Li-Ching; Chen, Yea-Ling; Chang, Fang‐Rong; Yang, San‐Nan; Tsai, Ching-Chung

doi:10.1186/s12906-021-03442-8

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…However, the muscarinic receptor antagonist atropine inhibited such contractions. These results showed that AN extract and arecoline induced contractions were mediated by muscarinic receptors indicating the possibility of developing as an alternative therapy for gastroesophageal reflux disease [71].…”

Section: Gastric and Intestinal Diseasesmentioning

confidence: 75%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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Areca nut (AN) is used for traditional herbal medicine and social activities in several countries. It was used as early as about A.D. 25-220 as a remedy. Traditionally, AN was applied for several medicinal functions. However, it was also reported to have toxicological effects. In this review article, we updated recent trends of research in addition to acquire new knowledge about AN. First, the history of AN usage from ancient years was described. Then, the chemical components of AN and their biological functions was compared; arecoline is an especially important compound in AN. AN extract has different effects caused by different components. Thus, the dual effects of AN with pharmacological and toxicological effects were summarized. Finally, we described perspectives, trends and challenges of AN. It will provide the insight of removing or modifying the toxic compounds of AN extractions for enhancing their pharmacological activity to treat several diseases in future applications.

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Section: Gastric and Intestinal Diseasesmentioning

confidence: 75%

The Controversial Roles of Areca Nut: Medicine or Toxin?

Liu

Chang

2023

IJMS

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“…Numerous studies have investigated the impact of GPCRs on LES contraction and revealed important findings. For instance, extracts from Arecae pericarpium have been shown to induce contractions in the porcine LES, which are potentially mediated by muscarinic (M) receptors (Tey et al, 2021). Activation of bombesin receptor subtypes 2 and 3 has been identified as responsible for mediating tonic contraction of the porcine LES following bombesin stimulation (Tsai et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Investigating the Mechanisms Underlying U46619-Induced Contraction on Porcine Lower Esophageal Sphincter

Kek,

Su,

Lin

et al. 2023

J Pharmacol Exp Ther

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Gastroesophageal reflux disease (GERD) is associated with an incompetent lower esophageal sphincter (LES), resulting in the reflux of gastric contents into the esophagus. U46619, a thromboxane A2 (TXA2) receptor agonist, induces contractions in various smooth muscles.Therefore, this study aimed to investigate the effects and mechanisms of action of U46619 on the porcine LES. To achieve this, contractions of the clasp and sling strips of the porcine LES, induced by U46619 were measured using isometric transducers. Furthermore, the contractile mechanism of U46619 in the porcine LES was investigated by pretreating the strips with atropine (a muscarinic receptor antagonist), tetrodotoxin (a neuronal sodium channel blocker), nifedipine (a calcium channel blocker), and Ca 2+ -free Krebs-Henseleit solution. Additionally, reverse transcription polymerase chain reaction and immunohistochemistry (IHC) were performed to determine the presence of the TXA2 receptor in porcine LES. The results of this study demonstrated that U46619 caused marked concentration-dependent contractions in both porcine sling and clasp strips. The mechanism of U46619-induced contraction of the porcine LES was found to be related to calcium channels. Furthermore, the reverse transcription PCR analysis and IHC revealed that the TXA2 receptor was expressed in the clasp and sling fibers of porcine LES. Consequently, this study suggests that U46619 mediates the contraction of porcine LES through calcium channels and has potential as a therapeutic approach for treating GERD.

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“…It was found that the contraction of the lower esophageal sphincter caused by these extracts and arecoline was not affected by tetrodotoxin inhibition but was significantly suppressed by atropine. This suggests that the contractions of the porcine lower esophageal sphincter induced by the extracts and arecoline of the AN may be dose-dependent and mediated through muscarinic receptors [ 38 ].…”

Section: Biological Effectsmentioning

confidence: 99%

Biological Effects and Biomedical Applications of Areca Nut and Its Extract

Tong,

Xu,

Tan

et al. 2024

Pharmaceuticals

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The dried, mature fruit of the palm tree species Areca catechu L. is known as the areca nut (AN) or betel nut. It is widely cultivated in the tropical regions. In many nations, AN is utilized for traditional herbal treatments or social activities. AN has historically been used to address various health issues, such as diarrhea, arthritis, dyspepsia, malaria, and so on. In this review, we have conducted a comprehensive summary of the biological effects and biomedical applications of AN and its extracts. Initially, we provided an overview of the constituents in AN extract. Subsequently, we summarized the biological effects of AN and its extracts on the digestive system, nervous system, and circulatory system. And we elucidated the contributions of AN and its extracts in antidepressant, anti-inflammatory, antioxidant, and antibacterial applications. Finally, we have discussed the challenges and future perspectives regarding the utilization of AN and its extracts as emerging pharmaceuticals or valuable adjuncts within the pharmaceutical field.

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Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

Cited by 6 publications

References 30 publications

The Controversial Roles of Areca Nut: Medicine or Toxin?

The Controversial Roles of Areca Nut: Medicine or Toxin?

Investigating the Mechanisms Underlying U46619-Induced Contraction on Porcine Lower Esophageal Sphincter

Biological Effects and Biomedical Applications of Areca Nut and Its Extract

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