Arecoline augments cellular proliferation in the prostate gland of male Wistar rats

Saha, Indraneel; Chatterjee, Aniruddha; Mondal, Anushree; Maiti, B. R.; Chatterji, Urmi

doi:10.1016/j.taap.2011.06.010

Cited by 21 publications

(21 citation statements)

References 46 publications

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“…The animals were divided into four groups (each group with 10 mice). Group I: mice were intraperitoneally injected with physiological saline as control; Group II: mice were orally administrated with vitamin C (10 mg/kg body weight) dissolved in physiological saline and vitamin E (100 mg/kg body weight) dissolved in the corn oil per day according to the previous study [26]; Group III: mice were intraperitoneally injected arecoline hydrobromide (10 mg/kg body weight) dissolved in physiological saline and each does was divided equally into half and was injected at 9 AM and 6 PM, respectively, according to pervious reports [27,28]; Group IV: mice were first orally administrated with the same does of vitamin C and vitamin E as Group II, 1 hour later, intraperitoneally injected with the same does of arecoline hydrobromide as Group III.…”

Section: Methodsmentioning

confidence: 99%

The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

Zhou

Sun

Yang

et al. 2014

Korean J Physiol Pharmacol

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Arecoline is a major alkaloid of areca nuts which are widely chewed by southeast Asian and it manifests various toxic effects in different organs of human and animals. In this work, mature mice were treated by vitamins C plus E, arecoline, or both daily for four weeks. The results showed that arecoline significantly increased the levels of serum alkaline phosphatase (ALP), glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) and significantly decreased the levels of reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) in the liver tissues. Additionally, the body weight, testis weight, sperm counts, motility and normal sperms also were significantly decreased. The supplement of vitamins C and E can bring the activities of ALP and GPT to normal levels and partially restore the sperm counts compared to the arecoline-treated group but have no other positive effects. In conclusion, the vitamins C and E partially attenuated the arecoline-induced hepatotoxiciy but basically had on protective effects against the arecoline-induced testicular toxicity.

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Section: Methodsmentioning

confidence: 99%

The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

Zhou

Sun

Yang

et al. 2014

Korean J Physiol Pharmacol

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“…Histologically, significant enlargement of the acini was also reported in glandular hyperplasia in rats. [22] We determined significantly greater acinar area in Group 2 than the other groups. Acinar area of sildenafil citrate group was less than BPH group without any significant difference with control group.…”

Section: Discussionmentioning

confidence: 90%

Effect of sildenafil citrate in testosterone induced benign prostate hyperplasia rat model

Çalışkan

Keleş

Öztürk

et al. 2017

Turkish Journal of Urology

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Objective: Efficacy of treatments for benign prostate hyperplasia (BPH) is limited because the disease has complex etiopathogenesis. Recent studies have demonstrated the presence of phosphodiesterase-5 (PDE-5) receptors in prostate tissue. We investigated efficacy of sildenafil citrate in testosteron -induced BPH in rats. Material and methods:The rats were divided into three groups. Each groups had 7 rats. Group 1 was control group. Testosteron propionate 3 mg/kg/day was injected subcutaneously for two weeks in Group 2. The same procedure was done for Group 3 and sildenafil citrate was added to water at daily doses of 2 mg/kg for two weeks. The rats were euthanized with intraperitoneal pentobarbital. The body weights were measured and the prostates were removed. Results:The mean weights of rats were 288±31.93, 345±23.23 and 294±32.86 g in Groups 1, 2 and 3, respectively. The mean prostate weights of rats were 0.74±0.18, 1.3±0.13 and 0.72±0.24 g in Groups 1, 2, and 3, respectively. Group 2 had statistically significantly higher prostate weights than the other groups (p<0.01). Relative prostate weight is calculated with ratio of prostate weight to body weight. BPH group showed an increase in relative prostate weight compared with other groups with significant difference (p= 0.036 and p= 0.040). There was statistical difference for acinar area between Group 2 and the others, no significant difference of number of acini, interstitial space and epithelial thickness. Group 2 has more papillary projections per acini than the other groups. Conclusion:Favourable effect of sildenafil citrate on dimensions of prostate but not all on histological parameters was observed. We expect that PDE-5 inhibitors might be a treatment option for BPH patients if the studies support our findings in the future.

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“…During the experiment, physiological saline, arecoline hydrobromide or a mixture of L-glutathione and arecoline hydrobromide were administered to corresponding group of mice by gavage twice daily for 15 or 30 days. The dosage of arecoline hydrobromide was determined according to a previous study (25). …”

Section: Methodsmentioning

confidence: 99%

Effect of autophagy‑associated proteins on the arecoline‑induced liver injury in mice

Wang

Song

et al. 2018

Exp Ther Med

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Arecoline can be used to treat diseases including glaucoma and tapeworm infection, however, long-term administration can cause severe adverse effects, including oral submucosal fibrosis, oral cancer, hepatic injury and liver cancer. Autophagy serves a role in these injuries. The present study established a mouse model of arecoline-induced hepatic injury and investigated the role of autophagy-associated proteins in this injury. The results indicated that the expression levels of the autophagy marker protein microtubule associated protein 1 light chain 3 B (MAP1LC3B) and autophagy-promoting protein beclin 1 were elevated in the injured hepatic cells, while the expression levels of a well-known negative regulator of autophagy, mammalian target of rapamycin (mTOR), were reduced. Following treatment of the hepatic injury with glutathione, the liver function improved and liver damage was reduced effectively. Compared with the control group, the expression levels of both MAP1LC3B and beclin 1 were significantly upregulated in the glutathione-treated mice, but the expression of mTOR was significantly downregulated. It may be concluded that in the process of protecting against arecoline-induced hepatic injury, glutathione cooperates with mTOR and beclin 1 to accelerate autophagy, maintaining stable cell morphology and cellular functions.

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Arecoline augments cellular proliferation in the prostate gland of male Wistar rats

Cited by 21 publications

References 46 publications

The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

The Hepatotoxicity and Testicular Toxicity Induced by Arecoline in Mice and Protective Effects of Vitamins C and E

Effect of sildenafil citrate in testosterone induced benign prostate hyperplasia rat model

Effect of autophagy‑associated proteins on the arecoline‑induced liver injury in mice

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