Arecoline plays dual role on adrenal function and glucose-glycogen homeostasis under thermal stress in mice

Dasgupta, Romi; Saha, Indraneel; Ray, Prajna Paramita; Maity, Aniruddha; Pradhan, D; Sarkar, H.; Maiti, B. R.

doi:10.1080/13813455.2018.1508238

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…A decrease in the OD of sections stained for glycogen was accompanied by a decrease in plasma CORT level (positive correlation). According to the literature data, the glycogen content depends not only on CORT but also on insulin and catecholamine levels, which affect the levels of enzymes and intermediate products of glucose and glycogen metabolism [ 27 , 28 ]. In our experiment, it was demonstrated for the first time that in HAP rats the dystrophic changes occur in the vast majority of liver cells, which becomes almost completely glycogen free and, instead, filled with vacuoles containing hydropic fluid and fats.…”

Section: Discussionmentioning

confidence: 99%

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

Kondashevskaya

Artem’eva

Алексанкина

et al. 2022

J Evol Biochem Phys

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The extraordinary situation of the 2019–2022 pandemic caused a dramatic jump in the incidence of post-traumatic stress disorder (PTSD). PTSD is currently regarded not only as a neuropsychiatric disorder, but also as a comorbidity accompanied by cardiovascular diseases, circulatory disorders, liver dysfunction, etc. The relationship between behavioral disorders and the degree of morphofunctional changes in the liver remains obscure. In this study, PTSD was modeled in sexually mature male Wistar rats using predatory stress induced by a prey’s fear for a predator. Testing in an elevated plus maze allowed the rat population to be divided into animals with low-anxiety (LAP) and high-anxiety (HAP) phenotypes. It was found that morphofunctional analysis of the liver, in contrast to its biochemical profiling, provides a clearer evidence that predatory stress induces liver dysfunction in rats of both phenotypes. This may indicate a decrease in the range of compensatory adaptive reactions in stressed animals. However, in HAP rats, the level of morphofunctional abnormalities in the mechanisms responsible for carbohydrate-fat, water-electrolyte and protein metabolism in the liver testified the prenosological state of the organ, while further functional loading and resulting tension of the regulatory systems could lead to homeostatic downregulation. Meanwhile, the liver of LAP animals was only characterized by insignificant diffuse changes. Thus, we demonstrate here a link between behavioral changes and the degree of morphofunctional transformation of the liver.

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Section: Discussionmentioning

confidence: 99%

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

Kondashevskaya

Artem’eva

Алексанкина

et al. 2022

J Evol Biochem Phys

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“…behavior somatic effects endocrine functions antidepressant activity, 43 motor restlessness, 44 reduced conditioned avoidance, 45 amnesia, 46 reduced exploration, 46 impaired spontaneous locomotion 99 and other behaviors, 100,101 reduced ethanolinduced impairment of the righting reflex 41 and sleep induced by phenobarbital, 102 potentiated morphine-evoked hyperactivity and behavioral sensitization 42 sister-chromatid exchanges in bone-marrow cells, 103 increased level of hepatic CYP2E1 protein, 104 elevated cGMP concentrations of the cerebellum and the cerebrum, 105 arrested splenic lymphocyte cell cycle and induced apoptosis, 106 direct muscarinic effect on the renal tubules (saluresis) 107 hypoglycemia, elevated glycogen level, 108 hypothyroid condition in metabolic stress, 109 inhibition of pineal-testis function, 110 stimulation of testosterone production by acting directly on Leydig cells. 111 Various nutrosamines, including N-nitrosoguvacoline, 3-(methylnitrosamino)propionitrile, and 3-(methylnitrosamino)propionaldehyde, 26−28 have been thought to form from areca alkaloids in the mouth, causing cancer in humans.…”

Section: Table 2 Summary Of Physiological Effect Of Arecoline In Rodentsmentioning

confidence: 99%

DARK Classics in Chemical Neuroscience: Arecoline

Volgin

Bashirzade

Amstislavskaya

et al. 2019

ACS Chem. Neurosci.

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Arecoline is a naturally occurring psychoactive alkaloid from areca (betel) nuts of the areca palm (Areca catechu) endemic to South and Southeast Asia. A partial agonist of nicotinic and muscarinic acetylcholine receptors, arecoline evokes multiple effects on the central nervous system (CNS), including stimulation, alertness, elation, and anxiolysis. Like nicotine, arecoline also evokes addiction and withdrawal symptoms (upon discontinuation). The abuse of areca nuts is widespread, with over 600 million users globally. The importance of arecoline is further supported by its being the world’s fourth most commonly used human psychoactive substance (after alcohol, nicotine, and caffeine). Here, we discuss neuropharmacology, pharmacokinetics, and metabolism of arecoline, as well as social and historical aspects of its use and abuse. Paralleling clinical findings, we also evaluate its effects in animal models and outline future clinical and preclinical CNS research in this field.

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Design, synthesis, and evaluation of novel arecoline-linked amino acid derivatives for insecticidal and antifungal activities

Pang,

Xu,

et al. 2024

Sci Rep

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A series of arecoline derivatives with amino acid moieties were designed and synthesised using an acylamide condensation strategy, taking arecoline as the foundational structure. The insecticidal efficacy of these compounds against Aphis craccivora and Tetranychus cinnabarinus was evaluated. Notably, derivatives 3h and 3i demonstrated superior insecticidal activity compared with arecoline. Additionally, 3h and 3i showed good fungicidal effectiveness against two types of plant fungi. Moreover, molecular docking analyses suggested that 3h and 3i could affect the nervous systems of A. craccivora and T. cinnabarinus by binding to neuronal nicotinic acetylcholine receptors. These findings suggest that compounds 3h and 3i represent promising leads for further development in insecticide and fungicide research.

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Arecoline plays dual role on adrenal function and glucose-glycogen homeostasis under thermal stress in mice

Cited by 3 publications

References 36 publications

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

Phenotypically Determined Liver Dysfunction in a Wistar Rat Model of Post-Traumatic Stress Disorder

DARK Classics in Chemical Neuroscience: Arecoline

Design, synthesis, and evaluation of novel arecoline-linked amino acid derivatives for insecticidal and antifungal activities

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