Arenobufagin causes ferroptosis in human gastric cancer cells by increasing rev-erbα expression

Chen, Ke; Li, Angling; Wang, Jian; Li, Dongchang; Wang, Xiaoshan; Li, Chengwei; Wang, Zhengguang

doi:10.1016/j.jtcme.2022.10.007

Cited by 8 publications

(1 citation statement)

References 45 publications

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“…Arenobufagin (ArBu) is a bufadienolide isolated from the skin and venom of toads, known for its broad anti-tumor properties. Research has shown that ArBu induces ferroptosis in GC cells by targeting and enhancing the expression of Rev-erbα( Chen et al, 2023b ). Moreover, ArBu has the potential to enhance sensitivity to cisplatin chemotherapy, making it a promising candidate for preventing GC progression and alleviating chemoresistance ( Si et al, 2022 ).…”

Section: Ferroptosis and Treatment Of Gcmentioning

confidence: 99%

Ferroptosis and its current progress in gastric cancer

Yue,

Yuan,

Zhou

et al. 2024

Front. Cell Dev. Biol.

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Gastric Cancer (GC) is a prevalent malignancy within the digestive tract, ranking as the fifth most common malignant tumor worldwide. It is characterized by clinical features such as a tendency for metastasis and an unfavorable prognosis. Ferroptosis, a recently identified form of cell death, represents a novel mode of cellular demise that diverges from the traditional concepts of necrosis and apoptosis. Numerous studies have found that ferroptosis plays a significant role in the proliferation, metastasis, drug resistance, and microenvironment regulation within GC. This review summarizes the mechanism of ferroptosis and its role in the occurrence and development of GC cells. It provides examples demonstrating how various anti-tumor drugs can induce ferroptosis in GC cells. Additionally, it summarizes the potential application value of ferroptosis in the future treatment of GC.

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Section: Ferroptosis and Treatment Of Gcmentioning

confidence: 99%

Ferroptosis and its current progress in gastric cancer

Yue,

Yuan,

Zhou

et al. 2024

Front. Cell Dev. Biol.

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Arenobufagin Induces Ferroptosis in Glioblastoma Cells via Modulating the MiR‐149‐5p/AEBP1 Axis

Hu,

Tang,

Xiang

et al. 2024

J of Applied Toxicology

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Accumulating evidences have proved Arenobufagin (ArBu) exhibited cytotoxic effects to multiple types of cancer. However, in glwioblastoma (GBM), which is easy to develop resistance to classic chemotherapy reagent, the therapeutic effects of ArBu have not been explored. In the current study, we found that GBM cells were sensitive to ArBu treatment and ArBu induced cell death both in a dose‐dependent and a time‐dependent manner. ArBu was observed to promote ROS accumulating and elevate Fe2+/MDA/GSH level, which lead to ferroptosis. Mechanistically, ArBu significantly downregulated AEBP1 expression and decreased the mRNA stability of AEBP1 without affecting its transcription. Then, AEBP1 mRNA was predicted to bind with miR‐149‐5p in GBM cells, which directly target its 3′UTR. At last, we found ArBu could upregulate miR‐149‐5p to suppress AEBP1 expression, and the rescue experiments confirmed miR‐149‐5p/AEBP1 axis regulated ferroptosis, which underlay the therapeutic effects of ArBu in GBM cells. This study revealed that ArBu induced ferroptosis in a dose‐dependent manner via modulating miR‐149‐5p/AEBP1 axis. It provides evidences for clinical application of ArBu for GBM.

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