Argan oil supplementation reduces hyperglycemia, dyslipidemia and oxidant stress in obese rats

Harrat, Nour El-imene; Tair, Zoubida Imene; Louala, Sabrine; Boukhari, N.; Dehiba, Faiza; Lamri‐Senhadji, Myriem

doi:10.30952/ns.4.1.4

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“…is result is in agreement with the study Hamalt et al [34] and Harrat et al [35], who showed that a 40% hyperfatty diet induced an increase in the body weight in Wistar rats. It is possible that the mechanisms regulating appetite respond more slowly to fat than to protein and carbohydrates.…”

Section: Discussionsupporting

confidence: 94%

Scolymus hispanicus (Golden Thistle) Ameliorates Hepatic Steatosis and Metabolic Syndrome by Reducing Lipid Accumulation, Oxidative Stress, and Inflammation in Rats under Hyperfatty Diet

Berdja

Boudarene

Smail

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Lipotoxicity is characterized by a metabolic disturbance leading to the development of nonalcoholic fatty liver disease (NAFLD). Some medicinal plant extracts exert hepatoprotective activity by modulating oxidative stress, inflammation, and metabolic disorders. Scolymus hispanicus or the golden thistle can be considered an important natural source of antioxidants. In traditional medicine, the consumption of this plant is recommended for diseases of the liver and intestines. Objective. In this study, we aimed to determine the effects of Scolymus hispanicus on a hyperfatty diet- (HFD-) induced metabolic disorders, oxidative stress, and inflammation. Materials and Methods. Our experiment focused on the administration of an HFD (40%) in Rattus norvegicus for 2 months and treatment with the aqueous extract of Scolymus hispanicus at a rate of 100 mg/kg during the last eight days of experimentation. In this context, several aspects were studied: the evaluation of blood biochemical parameters, liver function such as lipids and glycogen, markers of oxidative stress (TBARS, carbonyl proteins, advanced oxidation proteins, catalase, and SOD) and inflammation (NO and NFkB), morphological study of hepatocytes in primary culture, and histological study of the liver. Results. Lipotoxicity induced metabolic disorders, both serum and tissue. HFD induced an increase in the total lipids and a decrease in glycogen reserve and an alteration in the oxidant-antioxidant balance. HFD induced an increase in markers of liver damage, which resulted in NAFLD, confirmed by histological study and hepatocytes cell culture. Scolymus appears to have lipid-lowering, hypoglycemic, anti-inflammatory and antioxidant properties. It improved glucose tolerance and the condition of fatty liver disease. Conclusion. Golden thistle improves glucose tolerance and hyperlipidemia and ameliorates hepatic steatosis by reducing oxidative stress, inflammation, and lipid accumulation. Its incorporation into a dietary program or as an aliment supplement would prevent hepatic complications associated with an HFD.

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Section: Discussionsupporting

confidence: 94%