This research note explores variation in how political parties and presidents in Latin America responded to the COVID-19 pandemic. Relying on the Chapel Hill Expert Survey-Latin America (CHES-LA), we argue that preferences regarding the trade-off between virus containment and maintaining an open economy were shaped by the ideological positions of presidents and parties, particularly for more programmatic ones. This is largely consistent with findings in other world regions. Yet, beyond ideological orientation, populism, also had an important – though heterogeneous – effect on response preferences, with non-populists, particularly highly programmatic ones, more consistently supporting virus containment. In addition, both incumbents and more populist presidents and parties favoured further concentration of executive power to address the pandemic. These findings provide evidence of the importance of understanding how ideology, populism and programmatic linkages interact in Latin America’s party systems.