Argentine Hemorrhagic Fever

Weissenbacher, Mercedes; Laguens, Rubén P.; Coto, Celia E.

doi:10.1007/978-3-642-71726-0_4

Cited by 85 publications

(75 citation statements)

References 67 publications

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“…The other viruses include Junin virus (JUNV), Sabia virus (SABV), Guanarito virus (GTOV), and Chapare virus (CHPV). Machupo virus is the etiologic agent of Bolivian hemorrhagic fever (BHF), a disease clinically similar to Argentine hemorrhagic fever caused by JUNV (10,(13)(14)(15)(16)(17)(18)(19). The primary route of MACV exposure is believed to be through contact with aerosolized excretions and secretions from the rodent reservoir, Calomys callosus (9,20,21).…”

mentioning

confidence: 99%

Rescue of a Recombinant Machupo Virus from Cloned cDNAs and In Vivo Characterization in Interferon (αβ/γ) Receptor Double Knockout Mice

Patterson

Seregin

Huang

et al. 2014

J Virol

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Machupo virus (MACV) is the etiological agent of Bolivian hemorrhagic fever (BHF), a reemerging and neglected tropical disease associated with high mortality. The prototypical strain of MACV, Carvallo, was isolated from a human patient in 1963, but minimal in vitro and in vivo characterization has been reported. To this end, we utilized reverse genetics to rescue a pathogenic MACV from cloned cDNAs. The recombinant MACV (rMACV) had in vitro growth properties similar to those of the parental MACV. Both viruses caused similar disease development in alpha/beta and gamma interferon receptor knockout mice, including neurological disease development and high mortality. In addition, we have identified a novel murine model with mortality and neurological disease similar to BHF disease reported in humans and nonhuman primates.

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confidence: 99%

Rescue of a Recombinant Machupo Virus from Cloned cDNAs and In Vivo Characterization in Interferon (αβ/γ) Receptor Double Knockout Mice

Patterson

Seregin

Huang

et al. 2014

J Virol

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“…Notably, increased travel to and from regions of endemicity has led to the importation of LF into metropolitan areas, where the virus is not endemic, around the globe (11). Likewise, the NW arenavirus Junin virus causes Argentine HF, a severe illness with hemorrhagic and neurological manifestations and a fatality rate of 15 to 30% (7,22,27), while the NW Machupo and Guanarito arenaviruses have emerged as causative agents of HF in Bolivia and Venezuela, respectively (22). Public health concerns about HF arenavirus infections are exacerbated by the lack of licensed vaccines and by the fact that current antiarenavirus therapies are limited to the use of the nucleoside analogue ribavirin, which is only partially effective and is associated with significant side effects.…”

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confidence: 99%

The Z Protein of the New World Arenavirus Tacaribe Virus Has Bona Fide Budding Activity That Does Not Depend on Known Late Domain Motifs

Urata

Yasuda

Torre

2009

J Virol

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The arenavirus small RING finger Z protein has been shown to be the main driving force of budding for several arenaviruses. This Z budding activity was found to be mediated by the late (L)-domain motifs P(T/S)AP and PPXY, located at the C terminus of Z. Here, we show that the Z protein of Tacaribe virus (TACV), a New World arenavirus, buds efficiently from cells despite lacking the canonical L-domain motifs P(T/S)AP and PPXY. Likewise, potential L-domain motifs ASAP and YLCL present in TACV Z did not exhibit any significant contribution to TACV Z budding activity. Budding of TACV Z was Tsg101 independent but required the activity of Vps4A/B. These results indicate that TACV Z utilizes a budding mechanism distinct from that reported for other arenaviruses.Arenaviruses are enveloped viruses with a bisegmented, negative-strand (NS) RNA genome and a life cycle restricted to the cell cytoplasm (1). Each RNA segment uses an ambisense coding strategy to direct the expression of two genes that are in opposite orientations and separated by a noncoding intergenic region. The large segment (7.2 kb) encodes the late (L) protein, an RNA-dependent RNA polymerase, and the small RING finger protein Z, which is the counterpart of the matrix (M) protein found in many enveloped NS RNA viruses. The small segment (3.5 kb) encodes the viral nucleoprotein (NP) and the glycoprotein precursor

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“…Although our lead compounds were potent against phylogenetically distant arenaviruses, they did not show activity against other enveloped viruses with class I viral fusion proteins, indicating specificity for arenavirus GPmediated membrane fusion. 3 and the New World arenaviruses Junin (JUNV), Guanarito (GTOV), and Machupo (MACV), cause severe viral hemorrhagic fevers in humans and represent a serious public health problem (1). LASV is estimated to infect several hundred thousand individuals yearly in endemic regions of West Africa, resulting in significant mortality and high morbidity (2).…”

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confidence: 99%