Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity

Kim, Oh Yoen; Lee, Seung Min; Chung, Ji Hyung; Joo, Hyun Jin; Moon, Ji‐Young; Shin, Min Jeong

doi:10.1016/j.nut.2011.09.012

Cited by 48 publications

(37 citation statements)

References 32 publications

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“…In various cardiovascular disorders, arginase has been shown to regulate vascular cell functions primarily through impairment of NO production [9][10][11]. In line, we previously observed significant upregulation of arginase 1 in the peripheral blood mononuclear cells (PBMCs) of overweight/obese individuals [12], which suggested an association between arginase activity in the endothelium, eNOS-dependent NO production, and the endothelial dysfunction evident in obesity.…”

Section: Introductionsupporting

confidence: 54%

Arginase inhibition restores endothelial function in diet-induced obesity

Chung¹,

Moon²,

Lee³

et al. 2014

Biochemical and Biophysical Research Communications

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Section: Introductionsupporting

confidence: 54%

Arginase inhibition restores endothelial function in diet-induced obesity

Chung¹,

Moon²,

Lee³

et al. 2014

Biochemical and Biophysical Research Communications

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“…This mechanism may be potentially constrained to the airways, as biomarkers of systemic oxidative stress have been found not to explain the obesity-asthma association (24). Alternatively, higher arginase expression and activity, which have been respectively described in association with obesity or asthma, could also contribute to obese subjects with asthma having lower FE NO (18,25).…”

Section: Discussionmentioning

confidence: 99%

An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

Holguín

Comhair

Hazen

et al. 2013

Am J Respir Crit Care Med

154

114

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Rationale: Increasing body mass index (BMI) has been associated with less fractional exhaled nitric oxide (FE NO ). This may be explained by an increase in the concentration of asymmetric dimethyl arginine (ADMA) relative to L-arginine, which can lead to greater nitric oxide synthase uncoupling. Objectives: To compare this mechanism across age of asthma onset groups and determine its association with asthma morbidity and lung function. The log of plasma L-arginine/ADMA was inversely correlated with BMI in the late-(r ¼ 20.4, P ¼ 0.0006) in contrast to the early-onset phenotype (r ¼ 20.2, P ¼ 0.07). Although FE NO was inversely associated with BMI in the late-onset phenotype (P ¼ 0.02), the relationship was lost after adjusting for L-arginine/ADMA. Also in this phenotype, a reduced L-arginine/ADMA was associated with less IgE, increased respiratory symptoms, lower lung volumes, and worse asthma quality of life. Conclusions: In late-onset asthma phenotype, plasma ratios of L-arginine to ADMA may explain the inverse relationship of BMI to FE NO . In addition, these lower L-arginine/ADMA ratios are associated with reduced lung function and increased respiratory symptom frequency, suggesting a role in the pathobiology of the late-onset phenotype.Keywords: asthma; obesity; age of asthma onset; ADMA; arginine The extent to which obesity affects the health of people with asthma, and by what mechanisms, remains largely undetermined. Although adiposity imposes an important load on the respiratory system, beyond worsening dyspnea, there is little evidence that obesity affects asthma by increasing traditional biomarkers of airway inflammation or bronchial hyperresponsiveness. In fact, increasing body mass index (BMI) has been paradoxically associated with reduced levels of fractional exhaled nitric oxide (FE NO ) and sputum eosinophils (1-4). In addition, cluster analyses identify obesity as part of a phenotype characterized by less atopy and adult-onset asthma, with additional analyses suggesting obesity may be causally related to asthma among those with adult-onset asthma with less atopy (5, 6). In contrast, in those with childhood-onset more atopic asthma, the asthma appears to be causative for the weight gain (7). This difference in relationship among early-and late-onset asthma was conditionally confirmed in a study of obese subjects with asthma undergoing bariatric surgery (8). Loss of body weight improved respiratory Author Contributions: Contributed to manuscript preparation and design: F.H., S.S.K., S.C.E., S.E.W. Analyzed samples: S.C.E., R.W.P., S.L.H., S.A.A.C. Contributed with participant recruitment/sample: S.S.K., E.R.B., W.W.B., W.J.C., M.C., A.M.F., B.G., E.I., N.N.J., W.C.M., S.P.P., W.G.T., K.F.C., S.C.E., S.E.W.Correspondence and requests for reprints should be addressed to Fernando Holguin, M.D., M.P.H., Asthma Institute, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, MUH 628, 3459 Fifth Avenue, Pittsburgh, PA 15213. E-mail: holguinf@upmc.edu This article has an on...

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“…Furthermore, previous studies showed that VLDLR is related to body weight and adiposity in humans and mice (Brockmann et al, 1998;Kunej et al, 2013;Clemente-Postigo et al, 2011). Thus, VLDLR expression levels are likely associated with the phenotypic biomarkers for obesity (Kim et al, 2012). To date, most poultry VLDLR studies have focussed on reproduction because VLDLR can develop growing oocytes and deposit yolk lipoprotein (Shen et al, 1993;Wang et al, 2011;Wu et al, 2015), but the relationships between VLDLR polymorphism and fat deposition or body weight have not yet been investigated in poultry.…”

Section: Introductionmentioning

confidence: 93%

Association of VLDLR haplotypes with abdominal fat trait in ducks

Pan¹,

Dong

Chen

et al. 2017

Arch. Anim. Breed.

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Abstract. This study aimed to determine the correlation among VLDLR (very low-density lipoprotein receptor) gene polymorphisms, body weight and abdominal fat deposition of Gaoyou ducks. A total of 267 Gaoyou ducks from one pure line was employed for testing. The polymorphisms of the VLDLR gene were screened by polymerase chain reaction and DNA sequencing. Four novel single nucleotide polymorphisms (SNPs) (g.151G > A, g.170C > T, g.206A > G and g.278-295del) were identified in the 5'-UTR and signal peptide region. Furthermore, eight haplotypes were identified based on the four SNPs. The H8 was the most common haplotype with a frequency of more than 31 %. The four SNPs and their haplotype combinations were shown to be significantly associated with body weight at 6-10 weeks of age (P < 0.05 or P < 0.01) and abdominal fat percentage (AFP) (P < 0.05 or P < 0.01). Remarkably, the H1H1 diplotype had an effect on increasing body weight and decreasing AFP from the 6th to the 10th weeks of age. However, increasing positive effects of the H5H8 diplotype were observed for both body weight and AFP. This study suggests that the VLDLR gene plays an important role in the regulation of body weight and fat-related traits and may serve as a potential marker for the marker-assisted selection program during duck breeding.

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Arginase I and the very low-density lipoprotein receptor are associated with phenotypic biomarkers for obesity

Cited by 48 publications

References 32 publications

Arginase inhibition restores endothelial function in diet-induced obesity

Arginase inhibition restores endothelial function in diet-induced obesity

An Association between l-Arginine/Asymmetric Dimethyl Arginine Balance, Obesity, and the Age of Asthma Onset Phenotype

Association of VLDLR haplotypes with abdominal fat trait in ducks

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