Arginase inhibitor reduces fungal dissemination in murine pulmonary cryptococcosis by promoting anti-cryptococcal immunity

Hansakon, Adithap; Angkasekwinai, Pornpimon

doi:10.1016/j.intimp.2024.111995

Cited by 2 publications

(1 citation statement)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the A/J, BALB/c, CBA/J, and even DBA/J mouse strains can serve as a useful tool for identifying host factors that are absent or minimally elicited in C57BL/6J mice. 8 Publications [9][10][11]17,[134][135][136][137] 18 Publications [18][19][20]25,39,41,56,57,81,[138][139][140][141][142][143][144][145][146] A/J 0 Publications 0 Publications 3 Publications [39,56,57] BALB/c 9 Publications [69,71,72,[147][148][149][150][151][152] 1 Publication [153] 15 Publications [18,[39][40][41]56,138,142,143,[154][155]<...…”

Section: Recommendations For Inbred Mouse Strains Based On C Neoforma...mentioning

confidence: 99%

Inbred Mouse Models in Cryptococcus neoformans Research

Ding,

Nielsen

2024

JoF

View full text Add to dashboard Cite

Animal models are frequently used as surrogates to understand human disease. In the fungal pathogen Cryptococcus species complex, several variations of a mouse model of disease were developed that recapitulate different aspects of human disease. These mouse models have been implemented using various inbred and outbred mouse backgrounds, many of which have genetic differences that can influence host response and disease outcome. In this review, we will discuss the most commonly used inbred mouse backgrounds in C. neoformans infection models.

show abstract

Section: Recommendations For Inbred Mouse Strains Based On C Neoforma...mentioning

confidence: 99%

Inbred Mouse Models in Cryptococcus neoformans Research

Ding,

Nielsen

2024

JoF

View full text Add to dashboard Cite

show abstract

Immunometabolism: signaling pathways, homeostasis, and therapeutic targets

Xu,

He,

et al. 2024

MedComm

View full text Add to dashboard Cite

Immunometabolism plays a central role in sustaining immune system functionality and preserving physiological homeostasis within the organism. During the differentiation and activation, immune cells undergo metabolic reprogramming mediated by complex signaling pathways. Immune cells maintain homeostasis and are influenced by metabolic microenvironmental cues. A series of immunometabolic enzymes modulate immune cell function by metabolizing nutrients and accumulating metabolic products. These enzymes reverse immune cells’ differentiation, disrupt intracellular signaling pathways, and regulate immune responses, thereby influencing disease progression. The huge population of immune metabolic enzymes, the ubiquity, and the complexity of metabolic regulation have kept the immune metabolic mechanisms related to many diseases from being discovered, and what has been revealed so far is only the tip of the iceberg. This review comprehensively summarized the immune metabolic enzymes’ role in multiple immune cells such as T cells, macrophages, natural killer cells, and dendritic cells. By classifying and dissecting the immunometabolism mechanisms and the implications in diseases, summarizing and analyzing advancements in research and clinical applications of the inhibitors targeting these enzymes, this review is intended to provide a new perspective concerning immune metabolic enzymes for understanding the immune system, and offer novel insight into future therapeutic interventions.

show abstract

Arginase inhibitor reduces fungal dissemination in murine pulmonary cryptococcosis by promoting anti-cryptococcal immunity

Cited by 2 publications

References 53 publications

Inbred Mouse Models in Cryptococcus neoformans Research

Inbred Mouse Models in Cryptococcus neoformans Research

Immunometabolism: signaling pathways, homeostasis, and therapeutic targets

Contact Info

Product

Resources

About