2007
DOI: 10.1158/1078-0432.ccr-06-2197
|View full text |Cite
|
Sign up to set email alerts
|

Arginase, Prostaglandins, and Myeloid-Derived Suppressor Cells in Renal Cell Carcinoma

Abstract: Tumor-induced tolerance is a well-established phenomenon in cancer patients that can severely impair the therapeutic efficacy of immunotherapy. One mechanism leading to T-cell tolerance is the generation of myeloid-derived suppressor cells (MDSC) by soluble factors produced by the tumor. MDSC express CD11b + as a common marker but may vary in their stage of maturation, depending on the tumor factors being produced. Arginase production by MDSC depletes arginine from the tumor microenvironment and impairs T-cell… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

10
329
0
5

Year Published

2009
2009
2020
2020

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 433 publications
(344 citation statements)
references
References 24 publications
10
329
0
5
Order By: Relevance
“…Another immune function that could mediate the effects of surgery is myeloid-derived suppressor cells (MDSCs) (expressing CD11b/Gr-1 markers) that were shown to invade the spleen following traumatic stress and cause T cell dysfunction by an arginase-mediated mechanism (45). Indeed, in renal cell carcinoma patients, PGE 2 produced by the tumor was suggested to induce arginase-I expression in MDSCs, and depletion of MDSCs restored IFN-g production and T cell proliferation (46).…”
Section: Sectionmentioning
confidence: 99%
“…Another immune function that could mediate the effects of surgery is myeloid-derived suppressor cells (MDSCs) (expressing CD11b/Gr-1 markers) that were shown to invade the spleen following traumatic stress and cause T cell dysfunction by an arginase-mediated mechanism (45). Indeed, in renal cell carcinoma patients, PGE 2 produced by the tumor was suggested to induce arginase-I expression in MDSCs, and depletion of MDSCs restored IFN-g production and T cell proliferation (46).…”
Section: Sectionmentioning
confidence: 99%
“…In particular, the inhibition of COX-2 activity and PGE2 production reported to reduce the MDSC trafficking mediated by chemokines CXCR4/CXCL12 and CXCR1-CXCR2/CXCL8 [83] has been also shown to impair the MDSC-mediated immunosuppression through the down-regulation of ROS and NO production [117,118] or ARG-1 expression in these cells [119].…”
Section: Inhibiting Immunosuppressive Functions Of Mdscsmentioning
confidence: 99%
“…As the activity of indoleamine 2,3-dioxygenase (Munn et al, 2002) or arginase (Ochoa et al, 2007) can decrease the ability of DC to stimulate T cells, we tested the activity of both enzymes in DC differentiated under the effects of VEGF, without finding evidence of increased activity even in the presence of pharmacological antagonists (Supplementary Figure 1). The decrease in MLR stimulating activity caused by RCC culture supernatants could not be restored by bevacizumab, sorafenib or sunitinib, delivered either as single agent or in combination ( Figures 1B and 2B).…”
Section: Rcc Culture Supernatants Contain Abundant Vegf That Is Incrementioning
confidence: 99%