Arginine, citrulline and nitrate concentrations in the cerebrospinal fluid from patients with acute hydrocephalus

Pérez-Neri, Iván; Castro, Edwin; Montes, Sergio; Boll, Marie‐Catherine; Coll, J; Soto-Hernández, José Luís; Rı́os, Camilo

doi:10.1016/j.jchromb.2006.10.047

Cited by 22 publications

(13 citation statements)

References 41 publications

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“…13 The mobile phase consisted of an acetate buffer (AcO, 50 mmol/L, pH 5.9) with tetrahydrofuran and high-performance liquid chromatography-grade absolute methanol at a flow rate of 1.5 ml/min. The solvent program consisted of an isocratic elution (0-5 minutes) and a linear gradient (5-27 minutes) as follows: tetrahydrofuran 1.0%, 0-27 minutes; AcO 89%, 0-5 minutes, and 89%-77%, 5-27 minutes; absolute methanol 10%, 0-5 minutes, and 10%-22%, 5-27 minutes.…”

Section: Sample Processingmentioning

confidence: 99%

Plasma taurine as a predictor of poor outcome in patients with mild neurological deficits after aneurysmal subarachnoid hemorrhage

Coll¹,

Pérez-Neri

Avendaño³

et al. 2013

JNS

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Object. The object of this study was to determine the relationship between plasma taurine and subarachnoid hemorrhage (SAH) outcome.Methods. Forty patients with SAH and mild neurological deficits were included in this prospective, blinded cohort study. Plasma taurine levels were measured using high-performance liquid chromatography on admission and were correlated with patient outcomes at discharge.Results. Twenty-five percent of the patients ultimately had a poor outcome. Plasma taurine concentrations at admission were increased (2-fold) in SAH patients with a favorable outcome and were further increased (6-fold) in those who had a poor outcome. Increased taurine levels identified patients who would be discharged with a poor outcome, with sensitivity and specificity values of approximately 80% and 100%, respectively, and positive and negative predictive values of approximately 90%. Delayed cerebral vasospasm showed an OR of 27.9 (95% CI 1.090-714.9) for a poor outcome, whereas an increased taurine concentration had an OR of 105 for a poor outcome (95% CI 8.3-1328.0, p < 0.001).Conclusions. Increased plasma taurine concentrations on admission predict a poor outcome in SAH. J. Barges-Coll et al. 1022J Neurosurg / Volume 119 / October 2013 come predictor for Grades IV and V, but patients with a mild neurological deficit may unexpectedly have a poor outcome. 22 Up to 55% of patients with Fisher Grades 2 or 3 may have a poor outcome. 10,20 It is possible that the plasma taurine concentration may be elevated from the onset of SAH and may be associated with patient outcome, reflecting possible brain edema and explaining the unexpectedly poor outcome of patients with a mild neurological deficit after SAH. 17 Methods Study ParticipantsIn this prospective, blinded cohort study, approved by our institutional review board, we considered 211 consecutive patients who were admitted to the Emergency Department of our institute under the suspected diagnosis of a ruptured aneurysm (Fig. 1). Among these patients, only 41 fulfilled our study inclusion criteria: admission within the first 24 hours after SAH onset, HH Grade I-II, WFNS Grade I-II, 8 hours of fasting, not referred from another hospital, taking no medication during the previous 8 hours, and willingness to participate in the study and sign informed consent. One patient was excluded from the final analysis since taurine analysis was inconclusive. Data pertaining to demographic factors, comorbidities, Glasgow Coma Scale score, and HH grade were recorded on admission to the Emergency Department. Eighteen healthy volunteers were recruited as the control group.Routine blood analyses were performed (complete blood count, glucose, electrolytes, partial thromboplastin time, international normalized ratio). All patients underwent a 4-vessel digital angiography and CT study for the diagnosis of a ruptured aneurysm. Sample ProcessingA 20-ml blood sample was taken from every patient upon admission to the Emergency Department. Samples were labeled with a serial number and taken t...

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Section: Sample Processingmentioning

confidence: 99%

Plasma taurine as a predictor of poor outcome in patients with mild neurological deficits after aneurysmal subarachnoid hemorrhage

Coll¹,

Pérez-Neri

Avendaño³

et al. 2013

JNS

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“…MEASURES: CSF NO x concentration was determined by high-performace liquid chromatography (HPLC) coupled to UV spectrophotometry as previously reported by our group [17,18]. Briefly, samples were thawed and filtered through 0.45 lm pore diameter nylon membranes and eluted using an isocratic pump (1200 Series, Agilent Technologies).…”

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confidence: 99%

Imbalance Between Nitric Oxide and Dopamine May Underly Aggression in Acute Neurological Patients

et al. 2010

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The neurochemical basis of aggressive behavior in humans is not fully understood. In this study we explored the relationship between aggressiveness (as measured by the Overt Aggression Scale), cognitive performance (as measured by the Mini Mental State Examination), and biochemical markers of dopamine neurotransmission (homovanillic acid, HVA) and nitric oxide synthesis (nitrite plus nitrate, NO(x)) in cerebrospinal fluid from 70 patients with acute brain disorders, mainly brain infections. Aggressive behavior and cognitive performance showed an inverse correlation. NO(x)/HVA ratio was inversely correlated to aggressive behavior, and positively correlated to cognitive performance. A subanalysis with antipsychotic-naïve patients confirmed those results. The balance between nitric oxide and dopamine could be related to the cognitive control of aggressive impulse.

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“…Administration of L-arginine into the cerebrospinal fluid of the spinal cord (80 mg/20 ml) was accompanied a long-term increase in tonic activity of efferent fibers of the abdominal aortic nerves (by 15-20%). These changes reflect a prolonged activating effect of L-arginine on sympathetic structures.Nitric oxide (NO) has a role in interneuronal communication in the brain and spinal cord, which is mediated by a variety of synaptic and extrasynaptic processes [1,5,6,7,11,12]. Published data show that exogenous NO has various effects on neurons in various regions of the spinal cord, as well as on the cells located in the same lamina [13].…”

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confidence: 99%

“…Nitric oxide (NO) has a role in interneuronal communication in the brain and spinal cord, which is mediated by a variety of synaptic and extrasynaptic processes [1,5,6,7,11,12]. Published data show that exogenous NO has various effects on neurons in various regions of the spinal cord, as well as on the cells located in the same lamina [13].…”

mentioning

confidence: 99%

“…However, the mechanisms for NO-mediated regulation of these processes remain unknown. This is related to methodical errors, which results in the induction of nociceptive reflexes during laminectomy, exposure of the spinal cord, change in the fine mechanisms of interneuronal communication, and abnormal reaction to application of receptor ligands to the spinal cord [6,8,10,12].…”

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Impulse Flow in Sympathetic Efferents of the Abdominal Aortic Nerve after Intrathecal Administration of the Substrate and Inhibitor of Nitric Oxide Synthase

et al. 2009

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Experiments were performed on rats anesthetized with urethane and nembutal. Intrathecal administration of a nitric oxide inhibitor L-NAME (60 mg) into the cerebrospinal fluid of the thoracic spinal cord was followed by a 40-45% decrease in tonic activity of efferent fibers of the abdominal aortic nerves. L-NAME reduced a reflex increase in the rate of efferent impulses, which was induced by tetanic stimulation of afferent C-fibers in the mesenteric nerve. Administration of L-arginine into the cerebrospinal fluid of the spinal cord (80 mg/20 ml) was accompanied a long-term increase in tonic activity of efferent fibers of the abdominal aortic nerves (by 15-20%). These changes reflect a prolonged activating effect of L-arginine on sympathetic structures.

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Arginine, citrulline and nitrate concentrations in the cerebrospinal fluid from patients with acute hydrocephalus

Cited by 22 publications

References 41 publications

Plasma taurine as a predictor of poor outcome in patients with mild neurological deficits after aneurysmal subarachnoid hemorrhage

Plasma taurine as a predictor of poor outcome in patients with mild neurological deficits after aneurysmal subarachnoid hemorrhage

Imbalance Between Nitric Oxide and Dopamine May Underly Aggression in Acute Neurological Patients

Impulse Flow in Sympathetic Efferents of the Abdominal Aortic Nerve after Intrathecal Administration of the Substrate and Inhibitor of Nitric Oxide Synthase

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