Arginine Vasopressin Is Associated with Hypercortisolemia and Suicide Attempts in Depression

Inder, Wattrick J; Donald, R. A.; Prickett, Timothy C. R.; Frampton, Christopher; Sullivan, Patrick F.; Mulder, Roger; Joyce, Peter R.

doi:10.1016/s0006-3223(97)00301-6

Cited by 76 publications

(38 citation statements)

References 21 publications

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“…We replicated the finding that major depression is associated with a positive correlation between plasma AVP and cortisol levels (Inder et al, 1997). This correlation was due to a highly significant correlation between plasma AVP and cortisol levels in patients with anxious-retarded depression.…”

Section: Discussionsupporting

confidence: 82%

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Anxious–Retarded Depression: Relation with Plasma Vasopressin and Cortisol

Winter

Hemert

DeRijk

et al. 2003

Neuropsychopharmacol

106

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Dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis is related to melancholic or endogenous depression; however, the strength of this relationship depends on the definition of the specific depression subcategory. A two-dimensionally defined subcategory, anxious-retarded depression, is related to melancholic depression. Since arginine vasopressin (AVP) activates the HPA axis, and both major depression and the melancholic subcategory are associated with elevated plasma AVP levels, we investigated whether the plasma AVP level is also elevated in anxious-retarded depression, melancholic depression and anxious-retarded melancholic depression, and whether plasma AVP and cortisol levels are correlated in these subcategories. A total of 66 patients with major depression not using oral contraception were investigated. Patients with anxious-retarded depression had a highly significant AVP-cortisol correlation, while no such correlation was found in patients with nonanxious-retarded depression. Log-transformed mean plasma AVP values were higher in patients with anxious-retarded depression than in patients with nonanxious-retarded depression. Patients with anxious-retarded melancholic depression also had a significantly elevated level of plasma AVP and a highly significant correlation between plasma AVP and cortisol levels. The correlation was low in patients with melancholic depression. Anxious-retarded depression may be a useful refinement of the melancholic subcategory with regard to dysregulation of the HPA axis and plasma AVP release.

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Section: Discussionsupporting

confidence: 82%

“…Since plasma AVP and cortisol levels are correlated (Inder et al, 1997), we also investigated whether this is the case for anxious-retarded depression. Patients with nonanxiousretarded depression were used as control subjects.…”

Section: Introductionmentioning

confidence: 99%

Anxious–Retarded Depression: Relation with Plasma Vasopressin and Cortisol

Winter

Hemert

DeRijk

et al. 2003

Neuropsychopharmacol

106

View full text Add to dashboard Cite

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“…Patients with a history of violent suicide attempt are reported to have higher levels of urinary free cortisol (van Heeringen et al, 2000), higher serum cortisol levels in response to 5HTP (Meltzer et al, 1984), and DST nonsuppression (Roy, 1992 ;Coryell and Schlesser, 2001), but no difference in CSF CRH (Träskman-Bendz et al, 1992) compared with patients without such history. Studies comparing suicide attempters to nonattempters, regardless of the method of suicide attempt, do not agree as to whether cortisol levels are elevated (Inder et al, 1997 ;Roy, 1992). Thus, the bulk of the studies published to date support the notion that there is a relation between suicide and HPA activity, but the results are unclear with regard to suicide attempts.…”

Section: Hpa Axis Hyperactivity and Suicidal Behaviormentioning

confidence: 99%

“…In contrast, elevated cortisol levels have been reported in MDE (Westrin et al, 1999), and about half of the in-patients with MDE fail to suppress cortisol secretion after dexamethasone (Brown et al, 1987;Duval et al, 2001;Yehuda et al, 1996;Halbreich et al, 1989). Most (Coryell and Schlesser, 2001;Meltzer et al, 1984;Norman et al, 1990;Oei et al, 1990;Inder et al, 1997;Roy, 1992), but not all, (Cleare et al, 1996;Duval et al, 2001;Westrin et al, 1999) studies of HPA axis in suicidal behavior suggest that there is elevation of cortisol or dexamethasone resistance in future suicide completers. Some of these discrepancies may be related to the spectrum of suicidal behavior that is assessed, such that suicidal ideation or the presence of attempts in a subject's history may have less of an effect on cortisol secretion than the violence of the attempt (Roy, 1992) or ultimate suicide completion (Coryell and Schlesser, 2001).…”

Section: Introductionmentioning

confidence: 98%

Lower Cortisol Levels in Depressed Patients with Comorbid Post-Traumatic Stress Disorder

Oquendo

Echavarría

Galfalvy

et al. 2002

Neuropsychopharmacol

104

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Post-traumatic stress disorder (PTSD) is often comorbid with major depressive episodes (MDEs) and both conditions carry a higher rate of suicidal behavior. Hypothalamic-pituitary-adrenal (HPA) axis and serotonin abnormalities are associated with both conditions and suicidal behavior, but their inter-relation is not known. We determined cortisol response to placebo or fenfluramine in MDE, MDE and PTSD (MDE+PTSD), and healthy volunteers (HVs) and examined the relation of cortisol responses to suicidal behavior. A total of 58 medication-free patients with MDE (13 had MDE+PTSD) and 24 HVs were studied. They received placebo on the first day and fenfluramine on the second day. Cortisol levels were drawn before challenge and for 5 h thereafter. The MDE+PTSD group had the lowest plasma cortisol, the MDE group had the highest, and HVs had intermediate levels. There were no group differences in cortisol response to fenfluramine. Suicidal behavior, sex, and childhood history of abuse were not predictors of baseline or postchallenge plasma cortisol. Cortisol levels increased with age. This study finds elevated cortisol levels in MDE and is the first report of lower cortisol levels in MDE+PTSD. The findings underscore the impact of comorbidity of PTSD with MDE and highlight the importance of considering comorbidity in psychobiology.

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“…chronic mild stress as a model of depression (Duman, 2010, Yan et al, 2010, Overstreet, 2012) and the observed upregulation of AVP synthesis in parvocellular PVN neurons and V1b receptors at the anterior pituitary during chronic stress (Dallman, 1993, Aguilera et al, 1994 suggested the involvement of altered AVP signaling within the HPA axis in pathophysiological processes. Clinical studies found an increased AVP concentration in the cerebrospinal fluid (De Bellis et al, 1993, Heuser et al, 1998 and in the plasma (van Londen et al, 1997, van Londen et al, 1998, de Kloet et al, 2008 of depressive subjects, especially in suicide victims (Inder et al, 1997, Brunner et al, 2002. Postmortem studies have found an elevated number of AVP-expressing neurons, increased AVP level in the PVN (Purba et al, 1996, Merali et al, 2006 and an enhanced AVP mRNA You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) in the SON (Meynen et al, 2006).…”

mentioning

confidence: 99%

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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Short title:Stress-related behavior in Brattleboro rat after DDAVP treatment You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) Balázsfi et al. 2Highlights  The effect of AVP on affective and memory symptoms is due to its central role  DDAVP treatment compensated the peripheral effects of congenital AVP absence  DDAVP did not significantly alter the behavior of KO animals in the paradigms tested  AVP signaling in the medial amygdala contributes to the behavioral effect measured in FS AbstractBeside its hormonal function in salt and water homeostasis, vasopressin -released into distinct brain areas -plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP also corrects the behavioral alterations in AVP-deficient Brattleboro rats. Wild type (WT) and vasopressin-deficient (KO) male Brattleboro rats were tested.Half of the KO animals were treated by desmopressin (V2-receptor agonist) via osmotic minipump (subcutaneous) to eliminate the peripheral symptoms of vasopressin-deficiency. Anxiety was studied by elevated plus maze (EPM), defensive withdrawal (DW) and marble burying (MB) tests, while depressive-like changes were monitored in forced swimming (FS) and anhedonia by sucrose preference test. Cell activity was examined in septum and amygdala by c-Fos immunohistochemistry after 10min FS.

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Arginine Vasopressin Is Associated with Hypercortisolemia and Suicide Attempts in Depression

Cited by 76 publications

References 21 publications

Anxious–Retarded Depression: Relation with Plasma Vasopressin and Cortisol

Anxious–Retarded Depression: Relation with Plasma Vasopressin and Cortisol

Lower Cortisol Levels in Depressed Patients with Comorbid Post-Traumatic Stress Disorder

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

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