Arginine vasopressin significantly increases the rate of successful organ procurement in potential donors

Plurad, David; Bricker, Scott; Neville, Angela; Bongard, Frederic S.; Putnam, Brant

doi:10.1016/j.amjsurg.2012.05.011

Cited by 64 publications

(46 citation statements)

References 26 publications

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“…Early intervention with appropriate therapy may restore hemodynamic stability and prevent end-organ damage. A recent analysis of the OPTN database found that use of AVP in organ donors was independently associated with an increased rate of organ recovery (134). The study did not reveal the indications for AVP administration (e.g., hypotension and DI).…”

Section: When Should Treatment For Vasopressin Deficiency Be Considered?mentioning

confidence: 89%

“…In one randomized controlled trial evaluating the use of HRT, the initiation of vasopressin led to a complete withdrawal of norepinephrine, which resulted in an improvement in cardiac performance (133). Use of vasopressin in deceased organ donors has been associated with an increased rate of organ recovery (134).…”

Section: Are There Preferred Vasoactive Drugs Used For Organ Preservamentioning

confidence: 99%

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Management of the Potential Organ Donor in the ICU

Kotloff

Blosser

Fulda

et al. 2015

Critical Care Medicine

279

150

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This document was developed through the collaborative efforts of the Society of Critical Care Medicine, the American College of Chest Physicians, and the Association of Organ Procurement Organizations. Under the auspices of these societies, a multidisciplinary, multi-institutional task force was convened, incorporating expertise in critical care medicine, organ donor management, and transplantation. Members of the task force were divided into 13 subcommittees, each focused on one of the following general or organ-specific areas: death determination using neurologic criteria, donation after circulatory death determination, authorization process, general contraindications to donation, hemodynamic management, endocrine dysfunction and hormone replacement therapy, pediatric donor management, cardiac donation, lung donation, liver donation, kidney donation, small bowel donation, and pancreas donation. Subcommittees were charged with generating a series of management-related questions related to their topic. For each question, subcommittees provided a summary of relevant literature and specific recommendations. The specific recommendations were approved by all members of the task force and then assembled into a complete document. Because the available literature was overwhelmingly comprised of observational studies and case series, representing low-quality evidence, a decision was made that the document would assume the form of a consensus statement rather than a formally graded guideline. The goal of this document is to provide critical care practitioners with essential information and practical recommendations related to management of the potential organ donor, based on the available literature and expert consensus.

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Section: When Should Treatment For Vasopressin Deficiency Be Considered?mentioning

confidence: 89%

Section: Are There Preferred Vasoactive Drugs Used For Organ Preservamentioning

confidence: 99%

Management of the Potential Organ Donor in the ICU

Kotloff

Blosser

Fulda

et al. 2015

Critical Care Medicine

279

150

View full text Add to dashboard Cite

show abstract

“…35 Management of the cardiovascular changes resulting from the catecholamine surge after acute brain death improves systolic function and the chance of successful cardiac transplantation. 36 As previously mentioned, this autonomic storm takes place shortly after brain death and generally lasts only several hours.…”

Section: Cardiacmentioning

confidence: 99%

“…Furthermore, as previously mentioned, vasopressin has been shown to increase the rate of organ recovery both independently and as part of hormone replacement therapy in brain-dead organ donors. 35 Vasopressin infusion is dosed in the range of 0.01-0.04 IUÁmin -1 in order to minimize volume losses from diabetes insipidus and to assist blood pressure support. 44,45 Dopamine, at doses of \ 5 lgÁkg -1 Ámin -1 , improves blood flow to renal, mesenteric, and coronary vascular beds, thus enhancing organ perfusion, 46 but there is a lack of direct evidence that this effect leads to better graft survival or other beneficial outcomes.…”

Section: Musculoskeletal • Reflex Somatic Movements Mediated By Spinamentioning

confidence: 99%

“…Arginine vasopressin (AVP) should be used to reduce urine output and prevent a further increase in serum osmolarity. Furthermore, use of AVP in the brain-dead donor has been shown to increase the organ recovery rate and graft survival, 35 by decreasing plasma hyperosmolarity and improving systemic blood pressure as well as cardiac output. 44 A hypotonic fluid or free water infusion may need to be used to correct hypernatremia.…”

Section: Pulmonarymentioning

confidence: 99%

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