Arginine vasotocin enhances influx of testosterone in the newt brain

Moore, Frank L.; Zoeller, R. Thomas; Spielvogel, Sandra P.; Baum, Michael J.; Han, Suk Jin; Crews, David; Tokarz, Richard R.

doi:10.1016/0300-9629(81)90406-0

Cited by 7 publications

(3 citation statements)

References 19 publications

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“…A cooperative effect of androgens and AVT on sexual behavior in amphibians was first described in the newt Taricha #ranulosa by Moore et al (1981), and related to a direct action of the neuropeptide in the central nervous system (Moore and Miller 1983).…”

Section: Vocalizationsmentioning

confidence: 99%

Hormone-induced vocal behavior and midbrain auditory sensitivity in the green treefrog, Hyla cinerea

1992

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Twenty four castrated male, 6 intact male, and 11 intact female Hyla cinerea were injected subcutaneously with 25 micrograms arginine-vasotocin (AVT) and induced to call 1 h later in response to the playback of a conspecific mating call. Eighteen castrated males and 8 intact females were implanted 5 mg androgen pellets for 3 weeks prior to the neuropeptide injection. Among castrated males, 6/9 testosterone (T) implanted, 4/9 dihydrotestosterone (DHT) implanted and 2/6 non implanted individuals produced calls after being administered AVT. 5/6 intact non implanted males and 6/8 T intact implanted females also called, and 3 intact non implanted females remained silent after the injection. Evoked calls had a mid-frequency spectral peak at about 1900 Hz which is absent in field-recorded mating calls of this species. Calls of implanted females and castrated non implanted males were shorter than those of castrated implanted and intact non implanted males. Audiograms measured before hormone implants showed dips of enhanced sensitivity at about 0.5, 0.9 and 3.0 kHz in males and females. After AVT injection, thresholds at frequencies within the 0.7-1.5 kHz range were increased in castrated males. Such reduction in sensitivity points to an inhibition of the auditory system during hormone induced vocal activation.

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Section: Vocalizationsmentioning

confidence: 99%

Hormone-induced vocal behavior and midbrain auditory sensitivity in the green treefrog, Hyla cinerea

1992

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“…It has been recently reported that T administration increases the number of AVT-ir cells in the POA of female C. inornatus (Hillsman et al, 2007;Figure 26). In keeping with a facilitatory role for AVT in male-courtship behavior of the roughskin newt (Moore and Miller, 1983;Moore et al, 1981), and sexually dimorphic populations of AVT-ir cells in a variety of species (males > females), Hillsman et al (2007) hypothesize that androgenic modulation of AVT immunoreactivity might be central to the expression of male sexual behavior in the whiptail lizards studied.…”

Section: Arginine Vasotocinmentioning

confidence: 74%

Hormones, Brain, and Behavior in Reptiles

Crews

Sanderson

Dias

2009

Hormones, Brain and Behavior

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“…It is surprising that male sex hormones are thus ineffective since the preoptic arcas of both Rana and Xenopus are known to concentrate them (reviewed in Kelley & Pfaff 1978), and in R. pipiens both direct appli cation of testosterone into the preoptic area or electrical stimulation of this region will induce mating behavior (reviewed in Crews & Silver 1984) . The paradox may be clarifi ed by the demonstration of Moore and his colleagues (reviewed in Moore 1983) that the neurohypophseal polypeptide, arginine-8 vasotocin (AVT), synergizes with androgen to induce sexual behavior in the rough-skinned newt, T. granulosa, by acting directly on cells in the brain (Moore & Miller 1983) as well as increasing the infl ux of testosterone into the brain by changing the permeability of the blood-brain barrier (Moore et al 1981).…”

Section: Case Study 6: Neuroendocrine Events Underlying Amphibian Sexmentioning

confidence: 99%

Vertebrate Neuroethology: Definitions and Paradigms

Ingle¹,

Crews²

1985

Annu. Rev. Neurosci.

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INTRODUCTIONNeuroethology has its historical origins in three scientifi c disciplines: com parative neuroanatomy, comparative and physiological psychology, and com parative ethology. Neuroethology, however, avoids the emphasis on structure characteristic of comparative neuroanatomy and on task-oriented problems popular with psychologists, while drawing heavily on behavioral adaptations, the hallmark of comparative ethological investigations. Neuroethological stud ies measure an animal's competence, not its capabilities, by testing the organ ism under naturalistic conditions rather than under artifi cial conditions that may give rise to misleading results . Although the boundaries of neuroethology are arbitrary, its focus is on complex behaviors and not on simple reflexes such as coughing and eye-wiping. Instead of determining how simple reflexes become organized, integrated, and synthesized to form the foundation of com plex behaviors (cf Te itelbaum et al 1983), neuroethological studies begin with the behavioral sequence itself, concentrating on motivated or goal-directed behaviors that have adaptive value .Behavior is best viewed as the fi nal common pathway in a dynamic process involving the organism's external and internal milieux. One can arbitrarily divide this complex interaction into four aspects: 457 o 147-006X/85/030 1 -0457$02.00Annu. Rev. Neurosci. 1985.8:457-494. Downloaded from www.annualreviews.org by Indiana University -Purdue University Indianapolis -IUPUI on 10/17/12. For personal use only. Quick links to online content Further ANNUAL REVIEWS 458 INGLE & CREWS 1. the way in which the organism has become sensitive to certain physical,biotic, and social factors as key stimuli; 2. the mechanisms by which these stimuli are presented and integrated within the brain; 3. how this representation of the environment results in changes in the organ ism's internal state; 4. how those physiological changes in the internal milieu influence the manner in which the organism interacts with its environment.Superimposed on these physiological issues is the ethologist's traditional con cern for development, ecological fitness, and evolutionary history. Because one's definition of "neuroethology" depends upon one's definition of ethology, it seems useful to begin this review by identifying the questions raised by ethologists concerning the mechanisms of behavior and discussing their methods for description and analysis of behavior. Certainly, ethologists focus their attention upon the behavior of animals in nature or within laboratory environments where natural behaviors easily emerge. Ethological studies are typically concerned with (a) natural stimuli that elicit biologically important behaviors such as feeding, fleeing, courtship, and fighting; (b) the spatiotem poral structure of ensuing action pattens (pursuit, biting, threatening, calling, etc), and (c) the motivational, developmental, and physiological conditionsthat determine which alternative response is likely to be elicited by a given sct of cxtcrnal stim...

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Arginine vasotocin enhances influx of testosterone in the newt brain

Cited by 7 publications

References 19 publications

Hormone-induced vocal behavior and midbrain auditory sensitivity in the green treefrog, Hyla cinerea

Hormone-induced vocal behavior and midbrain auditory sensitivity in the green treefrog, Hyla cinerea

Hormones, Brain, and Behavior in Reptiles

Vertebrate Neuroethology: Definitions and Paradigms

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