Argon laser photocoagulation for treatment of presumed trematode-induced granulomatous anterior uveitis in children

Alsmman, Alahmady Hamad; Abdalla, Abdelsalam; Ezz-Eldawla, Mohammed; Mossa, Elshimaa A Mateen; Abozaid, Mortada A

doi:10.1136/bjophthalmol-2021-318796

Cited by 5 publications

(2 citation statements)

References 21 publications

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“…The same concept was followed in India [4,6]. Recently, in the Egyptian governorate, Sohag, Alsmman et al [9] applied argon laser to the anterior chamber nodules with or without medical treatment to treat similar ocular lesions. These preliminary identi cations may have come from the fact that these studies relied on traditional methods of examination as histopathology or conventional PCR using universal nonspeci c primers.…”

Section: Discussionmentioning

confidence: 99%

Novel Data About Unusual Location of Toxoplasma Gondii Within Active Microbial Community in the Anterior Chamber of the Eye of Egyptian Rural Children

Eleinen

Abdel-Aal

Nadar

et al. 2022

Preprint

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In Egypt, many cases of granulomatous anterior uveitis consisting of single or multiple gelatinous nodules were detected in children living in rural areas. These lesions are believed to be waterborne and were previously attributed to flatworms ‘stage, showing some improvement after antiparasitic treatment. In a trial to explore the nature of these ocular lesions among rural Egyptian children, twenty surgically excised ocular lesions were subjected to transmission electron microscopy (TEM) examination. TEM results were combined with previous results of the metagenomic analysis performed for four cases out of the twenty samples, revealing the presence of Toxoplasma gondii (T. gondii), besides, a wide range of microbial communities, including variable species of fungi, bacteria, and archaea. The excised lesions ranged from 1 to 5 mm in size and demonstrated an extensive inflammatory cellular infiltrate. Using TEM, five out of twenty samples revealed active eukaryotic organisms with intact energetic cellular organelles, besides, numerous nuclei encircled within a syncytial layer and enclosed by a hyaline layer rich in mitochondria. Six samples showed inactivity in the cellular and the covering portions, while just inflammatory reaction was seen in the remaining nine samples. Toxoplasma gondii was found free within the distal part of the syncytium while, the proximal part showed the active synthesis of possibly extra polymeric substance, perhaps secreted by the microbial community. In a conclusion, Toxoplasma gondii has been detected among a microbial community in an atypical lesion in the eye. Further studies need to be sustained on genotype characterization, proteomic analysis, besides, the aquatic transmission of these mixed microbial species to the ocular tissues to clarify the reason behind such ocular illness.

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Section: Discussionmentioning

confidence: 99%

Novel Data About Unusual Location of Toxoplasma Gondii Within Active Microbial Community in the Anterior Chamber of the Eye of Egyptian Rural Children

Eleinen

Abdel-Aal

Nadar

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, prompt treatment is crucial for a favorable outcome. Current treatment modalities used include the following: (1) corticosteroids either topical, regional, or systemic; [8] (2) antimicrobial medications with controversial results; [9] (3) laser photocoagulation; [20] (4) surgical treatment for cases not responding to conservative treatment [1,8,9].…”

Section: Discussionmentioning

confidence: 99%

Management of presumed trematode-induced granulomatous intermediate uveitis

Amin

Abdullatif

2022

Eye

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Purpose To describe the surgical management of presumed trematode-induced granulomatous intermediate uveitis (PTIGIU) not responding to medical treatment in controlling the inflammation. Methods A prospective, interventional, single-center study in which patients with a history of fresh canal water contact and PTIGIU were enrolled. All patients underwent lensectomy–pars plana vitrectomy (PPV) and post-operative control of inflammation, functional and anatomical outcomes were assessed. Results Fifteen eyes of 12 patients were included in the study with median age of 11.6 ± 4 yrs. Six months following lensectomy-PPV, inflammation was well controlled in all patients. The eyes were divided into two groups: Group A: 10 patients with an attached retina while Group B: 5 patients who were in the cicatricial stage with tractional retinal detachment. All patients in group A had CDVA of 20/40 or better, unlike patients in group B who failed to achieve a CDVA better than 20/70 throughout their follow-up. In group B, final anatomical success was achieved in only 40% with hypotony occurring in 20%. Conclusion PTIGIU is associated with the presence of ciliary body granuloma which, if left untreated, can lead to drastic outcomes. Early lensectomy-PPV represents a viable management option in cases resistant to medical treatment, with a favorable outcome.

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Metagenomic analysis of the ocular toxoplasmosis in children uveitis from Fayoum governorate, Egypt

Elmallawany,

Abdel-Aal,

Abu Eleinen

et al. 2024

Infection, Genetics and Evolution

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Argon laser photocoagulation for treatment of presumed trematode-induced granulomatous anterior uveitis in children

Cited by 5 publications

References 21 publications

Novel Data About Unusual Location of Toxoplasma Gondii Within Active Microbial Community in the Anterior Chamber of the Eye of Egyptian Rural Children

Novel Data About Unusual Location of Toxoplasma Gondii Within Active Microbial Community in the Anterior Chamber of the Eye of Egyptian Rural Children

Management of presumed trematode-induced granulomatous intermediate uveitis

Metagenomic analysis of the ocular toxoplasmosis in children uveitis from Fayoum governorate, Egypt

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