2023
DOI: 10.3390/medicina59010139
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ARHGAP21 Is Involved in the Carcinogenic Mechanism of Cholangiocarcinoma: A Study Based on Bioinformatic Analyses and Experimental Validation

Abstract: Background and Objectives: Rho GTPase-activating protein (RhoGAP) is a negative regulatory element of Rho GTPases and participates in tumorigenesis. Rho GTPase-activating protein 21 (ARHGAP21) is one of the RhoGAPs and its role in cholangiocarcinoma (CCA) has never been disclosed in any publications. Materials and Methods: The bioinformatics public datasets were utilized to investigate the expression patterns and mutations of ARHGAP21 as well as its prognostic significance in CCA. The biological functions of A… Show more

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“…The detailed processes of IHC and IF were described in supplementary materials. In addition, the manufacturer’s protocol of WB was performed as described [ 35 ]. All antibody used in the study were listed in Supplementary Table S3.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The detailed processes of IHC and IF were described in supplementary materials. In addition, the manufacturer’s protocol of WB was performed as described [ 35 ]. All antibody used in the study were listed in Supplementary Table S3.…”
Section: Methodsmentioning
confidence: 99%
“…The fixation and staining process followed a procedure similar to that employed in colony formation assays. The cell wound scratch assay was performed as reported previously [ 35 ].…”
Section: Methodsmentioning
confidence: 99%