Ariensin, a New Lignan from<i>Bursera ariensis</i>

Jd, Hernández; Lu, Román; Espiñeira, J.; Joseph‐Nathan, Pedro

doi:10.1055/s-2007-969989

Cited by 19 publications

(8 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It belongs to the fagaroides group and is poorly studied. From the acetonic extract of the bark, Hernandez isolated a new lignan named ariensin ( 12 ) [ 105 ]. Ariensin was shown to be active against the RAW246.7 murine cell line (IC 50 9.8 μM) [ 11 ].…”

Section: Genus Burseramentioning

confidence: 99%

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

2018

View full text Add to dashboard Cite

The genus Bursera belongs to the family Burseraceae and has been used in traditional Mexican medicine for treating various pathophysiological disorders. The most representative phytochemicals isolated from this genus are terpenoids and lignans. Lignans are phenolic metabolites known for their antioxidant, apoptotic, anti-cancer, anti-inflammatory, anti-bacterial, anti-viral, anti-fungal, and anti-protozoal properties. Though the genus includes more than 100 species, we have attempted to summarize the biological activities of the 34 lignans isolated from selected Mexican Bursera plants.

show abstract

Section: Genus Burseramentioning

confidence: 99%

An Ethnopharmacological, Phytochemical and Pharmacological Review on Lignans from Mexican Bursera spp.

2018

View full text Add to dashboard Cite

show abstract

“…B. schlechtendalii showed important cytotoxic activity, and this finding is in accordance with McDonield and Cole [18] study, since they identified two lignans with anti tumor activity in this species. In the case of B. ariensis notable cytotoxic effects from the hexane extract against all the cancer cell lines were obtained, and although there are no previous reports that evaluate the cytotoxic activity of this species, a lignan, denominated 'ariensin', was isolated from B. ariensis growing in the state of Michoacán [27,28], and was then synthesized by Burke and Stevenson [29], as well as later identified in Acanthopanax koreanum [30].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and Anti-inflammatory Activities of Bursera species from Mexico

Nunez¹

2014

J Clin Toxicol

View full text Add to dashboard Cite

Objective: Organic extracts from nine species (eleven populations) of the Bursera genus native to Mexico, were investigated for cytotoxic and anti-inflammatory activities. The influence of the cytotoxic plant extracts on cell cycle progression and apoptosis were also analyzed. Materials and methods: Cytotoxic activity from B. ariensis (Kunth) McVaugh and Rzed. Kew Bull (two populations), B. bicolor Engl., B. lancifolia Engl., B. glabrifolia Engl. (two populations), B. fagaroides (La Llave) Rez., Calderón and Medina, B. linanoe (La Llave) Rez., Calderón and Medina, B. galeottiana Engl., B. kerberi Engl., and B. excelsa Engl. were evaluated by the sulforhodamine B protein staining assay against four carcinoma cell lines: KB (nasopharyngeal), HF-6 (colon), MCF-7 (breast), and PC-3 (prostate), as well as on HFS-30 fibroblast normal skin cell line. Chloroform extracts from B. ariensis (two populations), B. kerberi and B. galeottiana were added to PC-3 cells to analyze percentage of cells in G1/S and G2/M phases by flow cytometric analysis, while apoptosis was determined in a fluorescence microscope. In vivo anti-inflammatory experiments were conducted through the 12-Otetradecanoylphorbol-13-acetate (TPA) induced ear edema in mice. Results: With the exception of B. glabrifolia and B. excelsa, hexane extracts of all the collected plant species displayed selective cytotoxic activity in at least one cell line. For the chloroform extracts, only B. bicolor, B. kerberi, B. galeottiana, and B. fagaroides exhibited cytotoxic activity, while for the ethyl acetate extracts B. fagaroides was the only plant displaying cytotoxic effect. There was no cytotoxic activity detected with methanol extracts. While B. galeottiana showed an important effect in G2/M arrest, induced apoptosis in PC-3 cells was detected with B. ariensis (two populations) and B. galeottiana. Important anti-inflammatory activity similar to the control indomethacin was displayed by B. galeottiana, B. excelsa, and B. schlechtendalii. Conclusion: Findings demonstrated that the studied species possess pharmacological potential qualities for developing plant medicines.

show abstract

“…An examination of an extract of the exudate of the bark of Bursera ariensis HBK (Burseraceae), reportedly used as a cicatrizing agent, was recently reported in this Journal (1). There was isolated a product, which was namend ariensin, and for which the structure (2R, 3R)-2,3-bis-(3 ,4-methylenedioxybenzyl)-1 ,4butanediol diacetate (1) was suggested on the basis of spectroscopic data (2).…”

Section: Introductionmentioning

confidence: 99%

“…Infusions and decoctions of thyme aerial parts are used in Spanish folk medicine in cases of whooping cough and as an antihelmintic (1), and are also used in Europe for treating coughs. In the last two years, the spasmolytic activity of some methoxylated flavones isolated from Thymus species has been estab- (6).…”

Section: Introductionmentioning

confidence: 99%