2011
DOI: 10.1371/journal.pmed.1000434
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Aripiprazole in the Maintenance Treatment of Bipolar Disorder: A Critical Review of the Evidence and Its Dissemination into the Scientific Literature

Abstract: A systematic search of the literature reveals limited evidence to support use of aripiprazole, a second-generation antipsychotic medication, in maintenance therapy of bipolar disorder, despite widespread use.

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Cited by 41 publications
(27 citation statements)
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References 94 publications
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“…None of the included trials provided data on long-term (i.e., $6 mo) outcomes comparing adjunctive antipsychotic medication treatment to adjunctive placebo. Our failure to find long-term outcome data is consistent with that of previous research teams [17,62]. For example, one systematic review of long-term, two-arm parallel randomized controlled antidepressant trials initially identified 2,693 abstracts, only to ultimately include six trials [62].…”
Section: Discussionsupporting
confidence: 78%
See 2 more Smart Citations
“…None of the included trials provided data on long-term (i.e., $6 mo) outcomes comparing adjunctive antipsychotic medication treatment to adjunctive placebo. Our failure to find long-term outcome data is consistent with that of previous research teams [17,62]. For example, one systematic review of long-term, two-arm parallel randomized controlled antidepressant trials initially identified 2,693 abstracts, only to ultimately include six trials [62].…”
Section: Discussionsupporting
confidence: 78%
“…Trials were included if they were acute-phase (i.e., not for relapse prevention or maintenance treatment [17,18]), placebocontrolled trials in which participants treated with antidepressant medications were randomly assigned to additionally receive an atypical antipsychotic medication or placebo. In order to meet our definition of treatment-resistant depression, participants must have been diagnosed with current major depressive disorder and must have been determined to have had an inadequate response to at least one course of antidepressant medication treatment prior to enrollment in the study.…”
Section: Study Selectionmentioning
confidence: 99%
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“…Overall, the presence of important methodological drawbacks in the design of maintenance studies makes conclusions difficult to generalize [514,531].…”
Section: Meta-analysismentioning
confidence: 99%
“…Pues bien: un interesante y metódico trabajo de Tsai et al (27) revisa la "evidencia" sobre la efectividad del producto en esta indicación y llega a la conclusión de que la condición de "estabilizador del humor" del aripiprazol se basa en un único ensayo, realizado por Keck et al, en el que además identifican cuatro "limitaciones críticas" que deberían invitar a interpretar sus hallazgos con suma cautela. Pese a ello, señalan, el estudio en cuestión se ha venido citando acríticamente desde su publicación en la literatura científica.…”
Section: Reguladores Del Humorunclassified