Aripiprazole-induced priapism

Trivedi, Satya K; Mangot, Ajish G; Sinha, Sonal

doi:10.4103/0972-6748.196044

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…This is the first case report referring to a severe case of hepatic toxicity due to aripiprazole on usual doses. Despite the good tolerance and few side effects of aripiprazole, several case reports have revealed some rare, but relevant, side effects of the drug, including tardive dyskinesia [16], neuroleptic malignant syndrome [17], acute dystonia [18], parkinsonism [19], hypersexuality [20], priapism [21,22], neutropenia [23], skin rash [24], hypertension [25], hyperlipidemia [26], hypersensitivity pneumonitis [27], Raynaud’s phenomenon [26], hyponatremia [28], and sialorrhea [29].…”

Section: Discussionmentioning

confidence: 99%

Aripiprazole-induced Hepatitis: A Case Report

Castanheira

Fernandes

Levy

et al. 2019

Clin Psychopharmacol Neurosci

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Aripiprazole is an atypical antipsychotic that acts as a partial agonist of dopamine type 2 receptors as well as 5-HT1A receptors. It is used in the treatment of schizophrenia and in type 1 bipolar disorder for mania. Because aripiprazole is well tolerated with few side effects it is used off-label in other psychotic disorders. The prevalence of abnormal liver function tests with antipsychotic use is 32%, with clinically significant effects in 4% of cases. No cases of aripiprazole-induced liver injury have been published. We report a 28-year-old female who presented with non-affective first-episode psychosis and who was treated with aripiprazole. Initially she was medicated with 10 mg per day, with an increase to 20 mg per day on the 12th day of hospitalization. Nine days after she became icteric, with nausea and had a vomiting episode. Laboratory analysis revealed a very high level of alanine aminotransferase, and minor to moderately high levels of aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and bilirubin. Aripiprazole was tapered and paliperidone was started with the improvement of clinical and laboratory findings.

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Section: Discussionmentioning

confidence: 99%

Aripiprazole-induced Hepatitis: A Case Report

Castanheira

Fernandes

Levy

et al. 2019

Clin Psychopharmacol Neurosci

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“…Most reports of antipsychotic-induced priapism are of the ischemic kind. Antipsychotics are thought to induce priapism due to their alpha-1 adrenergic receptor blockade [ 4 , 6 ]. This allows parasympathetic activity to dominate and allows persistent vasodilation and subsequent erection of the penis.…”

Section: Discussionmentioning

confidence: 99%

“…There has been another reported case of aripiprazole-induced priapism, onset within seven hours of taking his first 10 mg dose [ 6 ]. This case was resolved with a single 2 mL injection of adrenaline and required no repeat treatment.…”

Section: Discussionmentioning

confidence: 99%

Priapism in a 31-Year-Old Male With Paranoid Schizophrenia

Espiridion,

Saxena

2023

Cureus

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Priapism is a painful and emergent side effect that has been linked to some antipsychotics and other psychiatric medications, most often trazodone. This is thought to be due to some level of alpha-1 adrenergic blockade by these medications. Aripiprazole is an atypical antipsychotic with notably weak alpha-1 adrenergic antagonism. Thus, we report on a unique case of aripiprazole-induced priapism in a patient with schizophrenia and recurrent episodes of antipsychotic-induced priapism. This study offers insight into the potential mechanism of aripiprazole-induced priapism and offers alternative medications, such as olanzapine and lumateperone, to treat the patient's ongoing psychotic disorder.

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“…The most common cause of priapism is idiopathic, and other known causes include medications like antihypertensive drugs, selective serotonin reuptake inhibitors (SSRIs), phenothiazine, trazodone, and haloperidol; medical disorders like sickle cell disease (SCD); and illicit drugs like cocaine. The most common cause of priapism is medications in adults and SCD in children [1]. This is a case report of 30-year-old HIV-positive Caucasian male with history of schizoaffective disorder that developed painful penile erection after a single dose of sertraline 50 mg.…”

Section: Introductionmentioning

confidence: 99%

Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade

Sharma

2019

Case Reports in Psychiatry

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With increasing trend of polypharmacy, there are higher chances of drug-drug interactions leading to adverse effects, especially in psychiatric patients with co-morbid chronic medical problems. This case demonstrates a schizoaffective 30-year-old male on highly active antiretroviral therapy (HAART) who reported an incident of priapism potentially caused by an interaction between previously prescribed atypical antipsychotic, trazodone, norepinephrine dopamine reuptake inhibitor (NDRI), HAART, and newly added selective serotonin reuptake inhibitor (SSRI). This case emphasizes obtaining careful medication history, understanding cytochrome P450 (CYP450) enzyme and its subtypes, and discouraging polypharmacy. Clinicians must educate their patients about different sexual side effects as these can be socially stigmatizing and can further deteriorate mental health symptoms.

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Aripiprazole-induced priapism

Cited by 6 publications

References 13 publications

Aripiprazole-induced Hepatitis: A Case Report

Aripiprazole-induced Hepatitis: A Case Report

Priapism in a 31-Year-Old Male With Paranoid Schizophrenia

Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade

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