Aristolactams and 4,5-dioxoaporphines from Piper longum

A New Hydroxychavicol Dimer from the Roots of Piper betle

“…Recently, we found that the ethanolic extract of the roots of this plant exhibited anti-inflammatory effects. Chromatography of the ethanolic extract led to the isolation of a new phenolic compound, 2-('-hydroxychavicol)-hydroxychavicol (1), together with hydroxychavciol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6) [9][10][11][12][13] (Figure 1). Neutrophils play a pivotal role in the defense of the human body against infections.…”

The chemical constituents of Piper kadsura and their cytotoxic and anti-neuroinflammtaory activities

“…Piperolactam B (14) was also isolated from this source, and the 1 H NMR data of piperolactam B isolated from Piper longum was reported previously [33]. However, the assignments of the NMR data required correction.…”

Potential Anti‐Inflammatory Activities of Bractelactone and other Compounds Isolated from Fissistigma bracteolatum

“…In traditional medicine, this plant is used for curing broken bones and to stop bleeding [9]. This paper describes the structural elucidation and biological activity of a novel compound named bractelactone (1), isolated from the stems of F. bracteolatum, together with four known compounds: piperolactam A (2) [10], aristololactam BIII (3) [11], aristololactam BII (4) [11], and fissilandione (5) [6]. Compounds 1 ± 5 were investigated for their effects of formyl-lmethionyl-l-leucyl-l-phenylalanine (fMLP)-induced superoxide anion (O 1'')), and 107.6 (C(5')) confirmed the linkage between C(2'') and C(5').…”