Arjunolic Acid in Molecular Recognition: First Synthesis and Cation Binding Studies of a novel Arjuna-18-crown-6

Bag, Braja Gopal; Pramanik, Subhash R.; Maity, Gopal Chandra

doi:10.1080/10610270500067822

Cited by 20 publications

(9 citation statements)

References 30 publications

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“…Arjunolic acid was extracted following the method of King et al [20] and Bag et al [21]. Briefly, after collection the bark of TA was cut into small pieces, dried, and ground into powder (400 g), which was then extracted with petroleum ether (20 h) to remove greasy nonpolar materials.…”

Section: Extraction Of Arjunolic Acidmentioning

confidence: 99%

Protective effect of arjunolic acid against arsenic‐induced oxidative stress in mouse brain

Sinha

Manna

Sil

2008

J Biochem & Molecular Tox

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Arsenic, a notoriously poisonous metalloid, is ubiquitous in the environment, and it affects nearly all organ systems of animals including humans. The present study was designed to investigate the preventive role of a triterpenoid saponin, arjunolic acid against arsenic-induced oxidative damage in murine brain. Sodium arsenite was selected as a source of arsenic for this study. The free-radical-scavenging activity and the in vivo antioxidant power of arjunolic acid were determined from its 2,2-diphenyl-1-picryl hydrazyl radical scavenging ability and ferric reducing/antioxidant power assay, respectively. Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione. In addition, it enhanced the levels of lipid peroxidation end products and protein carbonyl content. Treatment with arjunolic acid at a dose of 20 mg/kg body weight for 4 days prior to arsenic administration almost normalized above indices. Histological findings due to arsenic intoxication and arjunolic acid treatment supported the other biochemical changes in murine brains. Results of 2,2-diphenyl-1-picryl hydrazyl radical scavenging and ferric reducing/antioxidant power assays clearly showed the in vitro radical scavenging as well as the in vivo antioxidant power of arjunolic acid, respectively. The effect of a well-established antioxidant, vitamin C, has been included in the study as a positive control. Combining all, results suggest that arjunolic acid possessed the ability to ameliorate arsenic-induced oxidative insult in murine brain and is probably due to its antioxidant activity.

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Section: Extraction Of Arjunolic Acidmentioning

confidence: 99%

Protective effect of arjunolic acid against arsenic‐induced oxidative stress in mouse brain

Sinha

Manna

Sil

2008

J Biochem & Molecular Tox

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“…The extraction of arjunolic acid from the bark of T. arjuna was carried out in our laboratory following the methods of King et al [8] and Bag et al [9]. Purity of the compound was checked by nuclear magnetic resonance (1H and 13C), infrared, mass spectrometry and melting point.…”

Section: Methodsmentioning

confidence: 99%

Protection of Arsenic‐Induced Hepatic Disorder by Arjunolic Acid

Manna

Sinha

Sil

2007

Basic Clin Pharma Tox

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Arsenic is one of the ubiquitous environmental pollutants, which affects nearly all organ systems. The present study has been carried out to investigate the hepatoprotective role of arjunolic acid, a triterpenoid saponin, against arsenicinduced oxidative damages in murine livers. Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols. In addition, sodium arsenite also increased the activities of serum marker enzymes, alanine transaminase and alkaline phosphatase, enhanced DNA fragmentation, protein carbonyl content, lipid peroxidation end-products and the level of oxidized glutathione. Studies with arjunolic acid show that in vitro it possesses free radical-scavenging and in vivo antioxidant activities. Treatment with arjunolic acid at a dose of 20 mg/kg body weight for 4 days prior to arsenic administration prevents the alterations of the activities of all antioxidant indices and levels of the other parameters studied. Histological studies revealed less centrilobular necrosis in the liver treated with arjunolic acid prior to arsenic intoxication compared to the liver treated with the toxin alone. Effects of a known antioxidant, vitamin C, have been included in the study as a positive control. In conclusion, the results suggest that arjunolic acid possesses the ability to attenuate arsenic-induced oxidative stress in murine liver probably via its antioxidant activity.

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“…The extraction of arjunolic acid was performed according to the method of King et al 19 and Bag et al 20 Briefly, after collection, the bark of T. arjuna was cut into small pieces, dried and ground into powder (1 kg) which was then extracted with petroleum ether (20 h) to remove greasy non-polar materials. After removing the petroleum ether, the crude material was subsequently extracted with diethylether (40 h).…”

Section: Extraction Of Arjunolic Acidmentioning

confidence: 99%