Arlyesterase activity of Paraoxonase-1 enzyme in Iraqi patients with β-thalassemia minor

Al-Ani, Ali W.; Fadel, Shaema S.

doi:10.36295/asro.2019.220820

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…It is usually used as an indicator for oxidative stress in many diseases. Several studies reported that oxidative stress contributes in the antioxidant reduction and the development of many diseases [36][37][38][39][40][41][42]. It has been reported that TAM induces the oxidative stress generation [43].…”

Section: Resultsmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Breast cancer (BC) is the most epidemic malignancy of women worldwide that leads to cause of morbidity and mortality. Tamoxifen (TAM) is the common therapy used in the BC treatment. Monoamine oxidases are enzymes linked to the progression of many types of carcinomas through its consideration on the production of reactive oxygen species. This study aimed to clarify the correlations between MAO isoforms (MAOs), atherogenic index, TAM, and their roles in the BC progression. 60 newly diagnosed and 60 TAM treated women with BC, as well as 50 healthy volunteers were included in this study. Parameters including MAOs activities, lipid profile, malondialdehyde, and total protein were determined before and after treatment with TAM. The activities of total MAO, MAO-A, MAO-B, and semi-carbazide-sensitive amine oxidase (SSAO) were significantly (P<0.0001) decreased in newly diagnosed and TAM-treated women compared with healthy individual. However, the activities of all tested enzymes were elevated significantly (P<0.0001) in TAMtreated women compared with the newly diagnosed women. The strong positive correlations were found among MAOs in response to TAM treatment. Receiver operating characteristic showed a higher sensitivity and specificity for MAOs in discrimination between newly diagnosed and TAM-treated women. Atherogenic index was significantly increased (P<0.0001) in newly diagnosed and in TAM-treated women compared with control. The findings of this study indicated that BC patients are more vulnerable to cardiovascular diseases, independent of TAM and MAOs effect. Based on the forgoing, MAOs can be used as a diagnostic marker for BC progression.

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Section: Resultsmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Coronary artery disease (CAD) is the most frequent cause of mortality in worldwide [1]. It is also called coronary heart disease, ischemic heart disease and heart disease.…”

Section: Introductionmentioning

confidence: 99%

Correlation between paraoxonase-1 arylesterase activities and clopidogrel drug in patients with coronary artery disease

Khudair

Numan

2022

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Background: Coronary artery disease (CAD) is one of the leading causes of death worldwide. Clopidogrel, antiplatelet drug, has been widely used for management of CAD. Arylesterase, the activity of Paraoxonase-1 (PON-1), is mainly contributed in the biotransformation of clopidogrel to its active thiol form. The purpose of this study was to investigate the effect of receiving clopidogrel drug on the arylesterase activities in CAD patients. The effect of receiving clopidogrel drug on the antioxidant activity of arylesterase was also monitored by determination of malondialdehyde (MDA) level. Methods: One hundred CAD patients, who were followed-up for 5 days after reciving clopidogrel, and 50 healthy volunteers were included in our study. The activities of arylesterase using two (phenyl acetate and p-nitrophenyl acetate) substrates, lipid profile, MDA, and total protein concentration (Tp) were determined spectrophotometrically. Results: PON-1 arylesterase activities, HDL-C, and Tp were significantly decreased (P<0.0001) in patients with CAD before receiving clopidogrel drug (CAD-pre-Clp) compared to baseline (non-CAD) and the levels of these parameters were returned to baseline (P>0.05) after 5 days of receiving clopidogrel (CAD-post-Clp).

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“…Oxidative stress (OS) is a state of unbalanced tissue oxidation refers to a condition in which cells are subjected to excessive levels of molecular oxygen or its chemical derivatives called reactive oxygen species (ROS) such as: hydrogen peroxide (H2O2) superoxide anions (O2 ⋅-), and hydroxyl radicals (OH ⋅ ). ROS is a highly reactive intermediates of the oxygen metabolism, that being generated and destroyed constantly [3]. Therefore, OS has been involved in aging process and a wide assortment of diseases such as: cardiovascular disease, neurodegenerative disorders, diabetes, and cancer [4].…”

Section: Introductionmentioning

confidence: 99%

Correlation between oxidative stress and clopidogrel drug in Iraqi patients with coronary artery disease

Khudair

Al-Ani

2022

ijhs

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Background: Coronary Artery Disease (CAD) is one of the largest causes of mortality worldwide. Clopidogrel, antiplatelet drug, has been widely used for management of CAD. The current study aimed to investigate the effect of clopidogrel on the oxidative stress in CAD patients. Methods: One hundred CAD patients, who were followed-up for 5 days after receiving clopidogrel, and 50 healthy volunteers were included in this study. Parameters include catalase (CAT), total antioxidant capacity (TAC), total oxidant capacity (TOC), total protein, albumin, and globulins were determined before and after treatment with clopidogrel. Results: CAT, TAC, and Tp were significantly decreased (P<0.0001) in CAD patients compared to healthy control and the levels of these parameters were returned to increase after receiving clopidogrel. However, TOC level was markedly increased (P<0.0001) in CAD patients and returned to decrease after treating with clopidogrel. Receiver operating characteristic curve showed that CAT gave a higher sensitivity (68-73%) and specificity (72%) as an indicator for monitoring of CAD progression. Conclusion: CAT activity and TAC were significantly increased as a response of receiving clopidogrel which is helpful to reduce the risk of CAD through scavenging of oxidants formation. These results also present CAT as a predictor variable of clopidogrel action.

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Arlyesterase activity of Paraoxonase-1 enzyme in Iraqi patients with β-thalassemia minor

Cited by 4 publications

References 28 publications

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Correlation between paraoxonase-1 arylesterase activities and clopidogrel drug in patients with coronary artery disease

Correlation between oxidative stress and clopidogrel drug in Iraqi patients with coronary artery disease

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