Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death

Lu, Dengfeng; Wang, Yi; Liu, Guangjie; Wang, Shixin; Duan, Aojie; Wang, Zongqi; Wang, Jing; Sun, Xiaoou; Wu, Yu Hsueh; Chen, Gang

doi:10.1016/j.nbd.2023.106228

Cited by 10 publications

(1 citation statement)

References 63 publications

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“…These findings suggested that Miro1 might provide neuroprotective effects through augmented mitochondrial transport. Our team explored the role of mitochondrial transport-associated Armcx1 in TBI ( Lu D. et al, 2023 ). It was found that Armcx1 expression was decreased in cortical tissues of TBI mice, and overexpression of it improved neuronal mitochondrial status, attenuated apoptosis, and was associated with better behavioral performance.…”

Section: Evidence For the Involvement Of Mitochondrial Transport In A...mentioning

confidence: 99%

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Lu,

Feng,

Liu

et al. 2023

Front. Neurosci.

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Ensuring mitochondrial quality is essential for maintaining neuronal homeostasis, and mitochondrial transport plays a vital role in mitochondrial quality control. In this review, we first provide an overview of neuronal mitochondrial transport, followed by a detailed description of the various motors and adaptors associated with the anterograde and retrograde transport of mitochondria. Subsequently, we review the modest evidence involving mitochondrial transport mechanisms that has surfaced in acute neurological disorders, including traumatic brain injury, spinal cord injury, spontaneous intracerebral hemorrhage, and ischemic stroke. An in-depth study of this area will help deepen our understanding of the mechanisms underlying the development of various acute neurological disorders and ultimately improve therapeutic options.

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Section: Evidence For the Involvement Of Mitochondrial Transport In A...mentioning

confidence: 99%

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Lu,

Feng,

Liu

et al. 2023

Front. Neurosci.

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Generation of an Armcx1 Conditional Knockout Mouse

Bright,

Bomze,

Bhaumik

et al. 2024

Genesis

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Armadillo repeat‐containing X‐linked protein‐1 (Armcx1) is a poorly characterized transmembrane protein that regulates mitochondrial transport in neurons. Its overexpression has been shown to induce neurite outgrowth in embryonic neurons and to promote retinal ganglion cell (RGC) survival and axonal regrowth in a mouse optic nerve crush model. In order to evaluate the functions of endogenous Armcx1 in vivo, we have created a conditional Armcx1 knockout mouse line in which the entire coding region of the Armcx1 gene is flanked by loxP sites. This Armcx1fl line was crossed with mouse strains in which Cre recombinase expression is driven by the promoters for β‐actin and Six3, in order to achieve deletion of Armcx1 globally and in retinal neurons, respectively. Having confirmed deletion of the gene, we proceeded to characterize the abundance and morphology of RGCs in Armcx1 knockout mice aged to 15 months. Under normal physiological conditions, no evidence of aberrant retinal or optic nerve development or RGC degeneration was observed in these mice. The Armcx1fl mouse should be valuable for future studies investigating mitochondrial morphology and transport in the absence of Armcx1 and in determining the susceptibility of Armcx1‐deficient neurons to degeneration in the setting of additional heritable or environmental stressors.

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Unravelling the impact of QRICH1 modulation on endoplasmic reticulum stress and neuronal apoptosis in traumatic brain injury

Wang,

Ren,

Duan

et al. 2025

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death

Cited by 10 publications

References 63 publications

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Mitochondrial transport in neurons and evidence for its involvement in acute neurological disorders

Generation of an Armcx1 Conditional Knockout Mouse

Unravelling the impact of QRICH1 modulation on endoplasmic reticulum stress and neuronal apoptosis in traumatic brain injury

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