Armin — A new coumarin from Artemisia armeniaca

Evaluation ofIn VitroAntimalarial Activity of Different Extracts ofArtemisia aucheriBoiss. andA. armeniacaLam. and Fractions of the Most Potent Extracts

“…Likewise, different extracts of A. aucheri have been reported to possess wound healing [ 17 ], leishmanicidal [ 18 , 19 ] and antifungal [ 20 ] effects. In the case of A. armeniaca , phytochemical evaluations on extracts and essential oil have been carried out and the presence of two new coumarin-hemiterpene ether glycosides [ 21 ], four prenylated coumarins, and some known flavonoids [ 22 , 23 ] was reported. The main constituent of the oil extracted from the aerial parts of A. armeniaca was found to be α -pinene [ 24 , 25 ].…”

Armenin and Isoarmenin – Two Prenylated Coumarins from the Aerial Parts of Artemisia armeniaca

“…Lacarol (3) and deoxylacarol (4) were previously reported from this plant [5] [8]. Compound 3 and structurally similar coumarins are unusual natural coumarins being rarely distributed in nature.…”

“…A. armeniaca is one of the 34 Artemisia species that occur in Iran [6] [7]. Previous phytochemical investigations on A. armeniaca revealed the presence of simple and prenylated coumarins [5] [8] [9], and a-pinene and 1,8-cineole were identified as the major components of the hydro-distilled oils of the aerial parts of this plant [4]. As part of our phytochemical and bioactivity studies on the genus Artemisia [10] [11], we now report on the isolation, identification, and free-radical-scavenging activity of four coumarins (1 -4), of which 1 and 2 are new, three flavonoids, 5 -7, chlorogenic acid (8), tryptophan (9), and a fatty acid (10) from the aerial parts of A. armeniaca.…”

“…-The reversed-phase (RP) preparative HPLC analyses of the MeOH extract of the aerial parts of A. armeniaca afforded four prenylated coumarins, 7-hydroxy-8-(4-hydroxy-3-methylbutoxy)coumarin (named armenin; 1), 8-hydroxy-7-(4-hydroxy-3-methylbutoxy)coumarin (named isoarmenin; 2), lacarol (3) [5] [8], and deoxylacarol (4) [5] [8], together with five other compounds including three flavonoid glycosides, quercetin 3-O-b-d-glucopyranoside (5) [12 -14], rutin (6) [12 -15], and kaempferol 3-O-b-d-glucopyranoside (7) [12] [14] [16], and chlorogenic acid (8) [17] and tryptophan (9) [14]. The only fatty acid, (10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid (b-dimophecolic acid; 10) [18], was isolated from the CH 2 Cl 2 extract.…”

New Coumarin-Hemiterpene Ether Glucosides and a Structurally Related Phenylpropanoic Acid Derivative from Artemisia Armeniaca

“…As part of our phytochemical studies on the Iranian flora, we have investigated A. armeniaca. Previous phytochemical studies of this species have led to the isolation of a series of coumarin-hemiterpene ethers [6,7]. α-Pinene and 1,8-cineole were found to be the main constituents of its essential oil [8].…”